Er：YAG激光能量对早期种植体周围炎的影响-《中国医学物理学杂志》

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Title:: Therapeutic effects of Er:YAG laser energy on early peri-implant inflammation

文章编号:: 1005-202X（2022）07-0893-05

作者:: 张绍芳; 郴州市第一人民医院北院口腔科，湖南郴州 423000

Author(s):: ZHANG Shaofang; Department of Stomatology, North Hospital, the First Peoples Hospital of Chenzhou city, Chenzhou 423000, China

关键词:: 激光; 早期种植体周围炎; 盐酸米诺环素; 龈沟液

Keywords:: Keywords: laser early peri-implant inflammation minocycline hydrochloride gingival crevicular fluid

分类号:: R781.4

DOI:: DOI:10.3969/j.issn.1005-202X.2022.07.018

文献标志码:: A

摘要:: 目的：研究不同参数Er：YAG激光能量照射对早期种植体周围炎（PI）的影响。方法：选择行种植修复出现早期PI患者108例为研究对象，采用随机数字法分为4组（各27例），A、B、C组分别用40、60、80 mJ的Er：YAG激光进行照射，1次/周，共治疗3次。对照组应用盐酸米诺环素治疗。治疗结束后第7、14、28和60天记录各组菌斑指数（PLI）、出血指数（BI）、探诊深度（PD）、骨缺损深度（DD）；治疗前及治疗结束后第60天检测各组龈沟液中的白介素1α（IL-1α）、C-反应蛋白（CRP）、肿瘤坏死因子（TNF-α）水平变化；比较各组治疗总有效率。结果：A、B、C组治疗总有效率分别为88.89%（24/27）、96.30%（26/27）和92.59%（25/27），均高于对照组的59.26%（16/27）（P<0.05）；治疗期间PLI、BI值呈下降趋势，且PLI、BI在各组间不同时期之间的改善均有统计学差异（P<0.05）；在治疗后第60天与A组相比，B、C组改善显著（P<0.05）；治疗后第7天，B、C组及对照组BI表达优于A组（P<0.05）。治疗后4组PD、DD表达均有显著差异（P<0.05）；在第14、28、60天时，B、C组BI表达优于A组和对照组（P<0.05）；DD在治疗后第60天各组间有显著差异（P<0.05），且B、C组效果优于A组和对照组（P<0.05）；A、B、C组龈沟液中的IL-1α、CRP和TNF-α水平均显著低于对照组（P<0.05），其中A、B、C组组间IL-1α、CRP、TNF-α水平表达有显著性差异（P<0.05）。结论：在安全范围内应用60 mJ的Er：YAG激光治疗早期PI临床疗效好，值得推广应用。

Abstract:: Abstract: Objective To study the therapeutic effects of Er:YAG laser irradiation of different energies on early peri-implant inflammation (PI). Methods A total of 108 patients with early PI after dental implantation were enrolled. According to random number table method, they were divided into 4 groups, with 27 cases in each group. Groups A, B and C were treated by 40, 60 and 80 mJ Er: YAG laser irradiation (once a week for 3 times), respectively. Control group was treated with minocycline hydrochloride.On the 7th, 14th, 28th and 60th days after the completion of treatment, plaque index (PLI), bleeding index (BI), probing depth (PD) and bone defect depth (DD) were recorded. Before the treatment and on the 60th day after the completion of treatment, the changes in the levels of interleukin 1α (IL-1α), C-reactive protein (CRP) and tumor necrosis factor α (TNF-α) in gingival crevicular fluid (GCF) were detected. The total response rates of treatment in different groups were also compared. Results The total response rates in groups A, B and C were 88.89% (24/27), 96.30% (26/27) and 92.59% (25/27), respectively, higher than 59.26% (16/27) in control group (P<0.05). During treatment, PLI and BI were decreased, and they were improved differently in different periods among different groups (P<0.05). Compared with those in group A on the 60th day after the completion of treatment, PLI and BI in group B and group C were improved significantly (P<0.05). On the 7th day after the completion of treatment, BI in group B, group C and control group was lower than that in group A (P<0.05). The PD and DD in the 4 groups were significantly different after treatment (P<0.05). On the 14th, 28th and 60th days after the completion of treatment, PD in group B and group C was lower than that in group A and control group (P<0.05). On the 60th day after the completion of treatment, the differences in DD among different groups were statistically significant (P<0.05), and the DD in groups B and C was less than that in group A and control group (P<0.05). The levels of IL-1α, CRP and TNF-α in GCF in groups A, B and C were significantly lower than those in control group (P<0.05), and there were statistical differences among groups A, B and C (P<0.05). Conclusion Within the safe range, 60 mJ Er:YAG laser has a good therapeutic efficacy in the treatment of early PI, worthy of popularizing.

《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]

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