[1]姚锡虎,周青云,张志诚,等.MRI纹理联合Cripto-1与SOX2蛋白对甲状腺乳头状癌颈部淋巴结转移的诊断价值[J].中国医学物理学杂志,2022,39(2):224-228.[doi:DOI:10.3969/j.issn.1005-202X.2022.02.016]
　YAO Xihu,ZHOU Qingyun,ZHANG Zhicheng,et al.Diagnostic value of MRI texture analysis combined with Cripto-1 and SOX2 protein expression in cervical lymph node metastasis of papillary thyroid carcinoma[J].Chinese Journal of Medical Physics,2022,39(2):224-228.[doi:DOI:10.3969/j.issn.1005-202X.2022.02.016]
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MRI纹理联合Cripto-1与SOX2蛋白对甲状腺乳头状癌颈部淋巴结转移的诊断价值()
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《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]

卷:
39卷
期数:
2022年第2期
页码:
224-228
栏目:
医学影像物理
出版日期:
2022-02-26

文章信息/Info

Title:
Diagnostic value of MRI texture analysis combined with Cripto-1 and SOX2 protein expression in cervical lymph node metastasis of papillary thyroid carcinoma
文章编号:
1005-202X（2022）02-0224-05
作者:
姚锡虎1; 周青云2; 张志诚3; 周建英4
1.福建医科大学附属泉州第一医院病理科， 福建 泉州 362000； 2.泉州医学高等专科学校附属人民医院放射科， 福建 泉州 362000； 3.重庆市第九人民医院放射科， 重庆 400700； 4.福建医科大学附属泉州第一医院疼痛科， 福建 泉州 362000
Author(s):
YAO Xihu1;  ZHOU Qingyun2;  ZHANG Zhicheng3;  ZHOU Jianying4
1. Department of Pathology, Quanzhou First Hospital Affiliated to Fujian Medical University, Quanzhou 362000, China 2. Department of Radiology, Peoples Hospital Affiliated to Quanzhou Medical College, Quanzhou 362000, China 3. Department of Radiology, the Ninth Peoples Hospital of Chongqing, Chongqing 400700, China 4. Department of Pain, Quanzhou First Hospital Affiliated to Fujian Medical University, Quanzhou 362000, China
关键词:
甲状腺乳头状癌; 颈部淋巴结转移; 磁共振成像; T2WI纹理; Cripto-1蛋白; SOX2蛋白
Keywords:
Keywords: papillary thyroid carcinoma cervical lymph node metastasis magnetic resonance imaging T2WI texture Cripto-1 protein SOX2 protein
分类号:
R445.2
DOI:
DOI:10.3969/j.issn.1005-202X.2022.02.016
文献标志码:
A
摘要:
目的：分析磁共振成像（MRI）T2加权成像（T2WI）纹理联合Cripto-1与SOX2蛋白在甲状腺乳头状癌（PTC）颈部淋巴结转移（LNM）中的诊断价值。方法：选择82例PTC患者，并留取患者根治术标本进行后期免疫组化研究。根据入选患者病理诊断结果，将42例LNM阳性者分为观察组，40例LNM阴性者分为对照组。分析MRI纹理参数联合Cripto-1与SOX2蛋白诊断PTC伴LNM的敏感度、特异度及符合率的临床价值。结果：Cripto-1蛋白在伴LNM的PTC中的阳性表达显著强于未伴LNM的PTC中的阳性表达（P<0.05）。Cripto-1蛋白免疫组化染色阳性表达多位于肿瘤周围组织，表现为棕黄色颗粒，主要位于细胞膜上，且Cripto-1蛋白在伴LNM的PTC中染色强度显著强于未伴LNM的PTC。SOX2蛋白在伴LNM的PTC中的阳性表达显著强于未伴LNM的PTC中的阳性表达（P<0.05）。SOX2蛋白免疫组化染色阳性表达多位于肿瘤周围组织，表现为棕黄色颗粒，主要位于细胞核上，且SOX2蛋白在伴LNM的PTC中染色强度显著强于未伴LNM的PTC。两组T2WI图像纹理分析的熵、角二阶矩以及相关间具有统计学意义（P<0.05），而逆差矩、偏度、对比、峰度以及均值间均无统计学意义（P>0.05）。预测PTC伴LNM的熵、角二阶矩以及相关对应AUC分别为0.884、0.783、0.718，敏感度分别为97.13%、79.42%、44.14%，特异度分别为70.00%、60.00%、90.00%。MRI纹理参数对PTC伴LNM的诊断价值稍优于Cripto-1蛋白，差异无统计学意义（P＞0.05）；而MRI纹理参数联合Cripto-1与SOX2蛋白诊断在敏感度、特异度及符合率方面均显著优于单独诊断（P<0.05）。结论：MRI纹理联合Cripto-1与SOX2蛋白诊断PTC伴LNM的敏感度、特异度及符合率均高于单独MRI纹理参数或Cripto-1蛋白的检查。此外，其有望为PTC患者预后及其治疗决策提供更可靠、准确的依据。
Abstract:
Abstract: Objective To analyze the value of magnetic resonance imaging (MRI) T2-weighted imaging (T2WI) texture analysis combined with Cripto-1 and SOX2 protein expression in diagnosing cervical lymph node metastasis (LNM) of papillary thyroid carcinoma (PTC). Methods A total of 82 patients with PTC were enrolled, and the radical operation specimens of the patients were collected for the subsequent immunohistochemical analysis. According to the results of pathological diagnosis, the patients were divided into observation group (LNM positive, n=42) and control group (LNM negative, n=40). The clinical value of MRI texture analysis combined with Cripto-1 and SOX2 protein expression in the diagnosis of PTC with LNM were assessed by analyzing their sensitivity, specificity and coincidence rate. Results The positive expression of Cripto-1 protein in PTC with LNM was significantly stronger than that in PTC without LNM (P<0.05). The positive expression of Cripto-1 protein immunohistochemical staining was mostly found in the surrounding tissues of the tumor, characterized by brown-yellow particles, mainly located on the cell membrane, and the staining intensity of Cripto-1 protein in PTC with LNM was significantly stronger than that in PTC without LNM. The positive expression of SOX2 protein in PTC with LNM was significantly stronger than that in PTC without LNM (P<0.05). The positive expression of SOX2 protein immunohistochemical staining was mostly found in the surrounding tissues of the tumor, characterized by brown-yellow particles, mainly located on the nucleus, and the staining intensity of SOX2 protein in PTC with LNM was significantly stronger than that in PTC without LNM. The results of T2WI image texture analysis revealed that there were significant differences between two groups in entropy, angular second moment and correlation (P<0.05), but not in inverse difference moment, skewness, contrast, kurtosis and mean values (P>0.05). The predicted AUC of entropy, angular second moment and correlation in PTC with LNM were 0.884, 0.783, 0.718, respectively and the sensitivities were 97.13%, 79.42%, 44.14% and the specificities were 70.00%, 60.00%, 90.00%. The diagnostic value of MRI texture analysis in PTC with LNM was slightly higher than that of Cripto-1 and SOX2 protein expression, but the difference was not statistically significant (P>0.05), while the sensitivity, specificity and coincidence rate of MRI texture analysis combined with Cripto-1 and SOX2 protein expression in the diagnosis of PTC with LNM were higher than those of MRI texture analysis or Cripto-1 and SOX2 protein expression alone (P<0.05). Conclusion The MRI texture analysis combined with Cripto-1 and SOX2 protein expression is superior to MRI texture analysis or Cripto-1 and SOX2 protein expression alone in sensitivity, specificity and coincidence rate. In addition, it is expected to provide a more reliable and accurate basis for the prognosis of PTC patients and their treatment decisions.

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备注/Memo

备注/Memo:
【收稿日期】2021-11-02 【基金项目】泉州市科技计划项目（2018Z078） 【作者简介】姚锡虎，硕士，副主任医师，研究方向：临床肿瘤，E-mail: liusuqing6666@163.com 【通信作者】周建英，硕士，副主任医师，研究方向：疼痛治疗，E-mail: caolina2016@163.com
更新日期/Last Update: 2022-03-07