[1]黄唯,徐中标,邓官华,等.MRI拉莫尔频率范围内人体脑胶质瘤组织的介电特性[J].中国医学物理学杂志,2021,38(12):1538-1543.[doi:DOI:10.3969/j.issn.1005-202X.2021.12.015]
 HUANG Wei,XU Zhongbiao,DENG Guanhua,et al.Dielectric properties of human glioma tissue at Larmor frequencies in MRI[J].Chinese Journal of Medical Physics,2021,38(12):1538-1543.[doi:DOI:10.3969/j.issn.1005-202X.2021.12.015]
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MRI拉莫尔频率范围内人体脑胶质瘤组织的介电特性()
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《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]

卷:
38卷
期数:
2021年第12期
页码:
1538-1543
栏目:
医学生物物理
出版日期:
2021-12-24

文章信息/Info

Title:
Dielectric properties of human glioma tissue at Larmor frequencies in MRI
文章编号:
1005-202X(2021)12-1538-06
作者:
黄唯1徐中标1邓官华2吕凤泉1李海南3蔡林波2梁瑜1
1.广东省人民医院(广东省医学科学院)放疗科, 广东 广州 510080; 2.广东三九脑科医院肿瘤综合治疗中心, 广东 广州 510510; 3.广东三九脑科医院病理科, 广东 广州 510510
Author(s):
HUANG Wei1 XU Zhongbiao1 DENG Guanhua2 L?Fengquan1 LI Hainan3 CAI Linbo2 LIANG Yu1
1. Department of Radiation Oncology, Guangdong Provincial Peoples Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510080, China 2. Department of Oncology, Guangdong Sanjiu Brain Hospital, Guangzhou 510510, China 3. Department of Pathology, Guangdong Sanjiu Brain Hospital, Guangzhou 510510, China
关键词:
脑胶质瘤开端同轴线法拉莫尔频率介电特性
Keywords:
Keywords: glioma tissue open-ended coaxial line Larmor frequency electrical property
分类号:
R318.4
DOI:
DOI:10.3969/j.issn.1005-202X.2021.12.015
文献标志码:
A
摘要:
目的:研究人体脑胶质瘤组织在MRI拉莫尔频率范围内(50~500 MHz)的介电特性,建立人体脑胶质瘤组织介电参数频率谱图,为磁共振断层成像技术提供理论依据和数据参考。方法:以神经外科手术中切下的脑胶质瘤组织为标本,在温度为37 °C的恒温水箱中,利用开端同轴线法,在50~500 MHz频率范围内使用AV 3656A网络分析仪测量脑胶质瘤组织标本的介电特性。以四阶Cole-Cole模型为基础,利用最小二乘曲线拟合方法,提取人体脑胶质瘤组织的介电特征参数。同时,将实验测得的脑胶质瘤组织介电特性与健康人体组织介电特性数据库中的正常脑组织进行比较。结果:在测频率范围内,人体脑胶质瘤组织实测数据与Cole-Cole模型吻合良好,且有人体脑胶质瘤组织的相对介电常数比正常脑组织高29.5%~36.6%,电导率比正常脑组织高56.1%~64.8%。结论:本文报道了37 °C下人体脑胶质瘤组织在MRI拉莫尔频率范围内(50~500 MHz)的介电特性数据及相应的Cole-Cole模型介电特征参数,可为人体脑胶质瘤组织介电特性研究和磁共振断层成像技术提供基础数据。
Abstract:
Abstract: Objective To investigate the dielectric properties of human glioma tissue at Larmor frequencies in MRI (50-500 MHz) and to establish the dielectric parameter frequency spectrum of human glioma tissue, thereby providing theoretical basis and reference data for magnetic resonance electrical property tomography (MREPT). Methods The glioma tissue which was removed from the brain during neurosurgery was taken as specimen. In a thermostatic water container with the temperature controlled at 37 °C, open-ended coaxial line method was used to measure the dielectric properties of human glioma tissue specimen via AV 3656A network analyzer at the frequencies between 50 MHz and 500 MHz. The dielectric characteristic parameters of human glioma tissue were obtained by the least square curve fitting method based on fourth-order Cole-Cole model. Finally, the dielectric properties of glioma tissue which were measured in the experiment were compared with those of normal brain tissue in a healthy human tissue dielectric property database. Results The measured data were fit closely with Cole-Cole model at the frequencies. The relative dielectric constant of human glioma tissue was 29.5%-36.6% high than that of the normal tissue and the conductivity was 56.1%-64.8% higher than that of normal tissue. Conclusion The dielectric properties of human glioma tissue are measured at Larmor frequencies in MRI (50-500 MHz) at 37 °C, and the dielectric characteristic parameters of the corresponding Cole-Cole model are also obtained in the study, which provide basic data for the research on the dielectric properties of human glioma tissue and MREPT.

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备注/Memo

备注/Memo:
【收稿日期】2021-08-21 【基金项目】广东省基础与应用基础研究基金(2019A1515111182);广东省医学科学技术研究基金(A2019315);广东省人民医院国自然配套启动资金资助项目(6200010127) 【作者简介】黄唯,工程师,研究方向:肿瘤早期发现及治疗,E-mail: huangwei_0118@163.com 【通信作者】梁瑜,工程师,研究方向:肿瘤放射物理,E-mail: gzyjs_ly@126.com
更新日期/Last Update: 2021-12-24