[1]黄超,彭伟强,吴海涛,等.根除儿童口腔幽门螺杆菌预防胃内幽门螺杆菌感染的多中心研究[J].中国医学物理学杂志,2021,38(6):785-787.[doi:DOI:10.3969/j.issn.1005-202X.2021.06.023]
　HUANG Chao,PENG Weiqiang,WU Haitao,et al.A multicenter study on eradication of oral Helicobacter pylori in children to prevent gastric Helicobacter pylori infection[J].Chinese Journal of Medical Physics,2021,38(6):785-787.[doi:DOI:10.3969/j.issn.1005-202X.2021.06.023]
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根除儿童口腔幽门螺杆菌预防胃内幽门螺杆菌感染的多中心研究()
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《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]

卷:
38卷
期数:
2021年第6期
页码:
785-787
栏目:
医学生物物理
出版日期:
2021-06-29

文章信息/Info

Title:
A multicenter study on eradication of oral Helicobacter pylori in children to prevent gastric Helicobacter pylori infection
文章编号:
1005-202X（2021）06-0785-03
作者:
黄超1; 彭伟强2; 吴海涛3; 程水颖2; 陈姣姣4; 赵庆波5; 钟海彬6; 马健7; 赵莉4
1.广州医科大学附属深圳沙井医院（深圳市中西医结合医院）脾胃病科， 广东 深圳 518104； 2.东莞口腔医院综合科， 广东 东莞 523000； 3.东莞口腔医院种植科， 广东 东莞 523000； 4.东莞口腔医院牙周科， 广东 东莞 523000； 5.广东医创时代科技发展有限公司， 广东 广州 511442； 6.五华县中医医院内科II区， 广东 梅州 514400； 7.青海省黄南藏族自治州人民医院， 青海 黄南 811300
Author(s):
HUANG Chao1;  PENG Weiqiang2;  WU Haitao3; ?HENG Shuiying2; ?HEN Jiaojiao4;  ZHAO Qingbo5;  ZHONG Haibin6; ?MA Jian7;  ZHAO Li4
1. Department of Spleen and Stomach, Shenzhen Shajing Hospital Affiliated to Guangzhou Medical University (Shenzhen Hospital of Integrated Traditional Chinese and Western Medicine), Shenzhen 518104, China 2. General Department, Dongguan Dental Hospital, Dongguan 523000, China 3. Department of Dental Implantation, Dongguan Dental Hospital, Dongguan 523000, China 4. Department of Periodontology, Dongguan Dental Hospital, Dongguan 523000, China 5. Guangdong Etron Technology Development Co., Ltd, Guangzhou 511442, China 6. Internal Medicine Area II, Wuhua Hospital of Traditional Chinese Medicine, Meizhou 514400, China 7. Peoples Hospital of Huangnan Tibetan Autonomous Prefecture of Qinghai Province, Huangnan 811300, China
关键词:
口腔; 胃; 儿童; 幽门螺杆菌感染
Keywords:
Keywords: oral cavity stomach children Helicobacter pylori infection
分类号:
R37；R573
DOI:
DOI:10.3969/j.issn.1005-202X.2021.06.023
文献标志码:
A
摘要:
目的：探讨根除儿童口腔幽门螺杆菌（Hp）预防胃内Hp感染的可能性。方法：采用多中心前瞻随机研究，选取口腔Hp阳性但胃内Hp阴性的幼儿园儿童共计427例，随机分为使用“无幽梅”牙膏组与普通牙膏组，分别接受“无幽梅”牙膏和普通牙膏。疗程结束后，再次检测口腔Hp，将口腔Hp阳性及阴性患者各分为一组，1年后行C13呼气试验检查，分析两组患者胃内Hp感染情况。口腔Hp检测方法采用特异度及敏感度双高的套式PCR方法。结果：随访1年，口腔Hp阴性组胃内Hp感染率为0.51%，口腔Hp阳性组胃内Hp感染率为6.51%，两组统计差异具有显著性（P<0.01）。结论：儿童根除口腔Hp可以降低胃内Hp感染的发生。
Abstract:
Abstract: Objective To investigate the possibility of preventing gastric Helicobacter pylori (Hp) infection by eradicating oral Hp in children. Methods A multicenter prospective randomized study was conducted on 427 kindergarten children who had Hp positive expression in oral cavity but Hp negative expression in stomach. According to the treatment, the children were randomly divided into two groups, namely wuyoumei toothpaste group and ordinary toothpaste group. After the completion of treatment course, oral Hp was detected again, and according to the detection results, the children were grouped into oral Hp positive expression group and negative expression group. One year later, C13 breath test was performed to analyze the gastric Hp infection in two groups. In the study, oral Hp was detected by nested PCR with high specificity and high sensitivity. Results One-year follow-up showed that the gastric Hp infection rate was 0.51% in oral Hp negative expression group and 6.51% in oral Hp positive expression group, with significant differences between two groups (P<0.01). Conclusion Eradication of oral Hp in children can reduce the incidence of gastric Hp infection.

相似文献/References:

[1]万俊,王远军,王丽嘉,等.口腔全景锥形束CT图像重建算法[J].中国医学物理学杂志,2016,33(5):437.[doi:10.3969/j.issn.1005-202X.2016.05.002]
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[2]曹洋森,朱晓斐,韩妙飞,等.基于级联式深度网络模型的胃及胰腺自动分割研究[J].中国医学物理学杂志,2021,38(8):971.[doi:DOI:10.3969/j.issn.1005-202X.2021.08.010]
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备注/Memo

备注/Memo:
【收稿日期】2021-04-19 【基金项目】广东省医学科研基金（B2019242） 【作者简介】黄超，硕士，副主任医师，研究方向：胃粘膜保护及内镜下微创治疗，E-mail: hc2558@126.com 【通信作者】赵莉，博士，科主任，E-mail: zhaoli790@126.com
更新日期/Last Update: 2021-06-29