[1]袁伟文,江桂华,罗泽斌.血管迂曲结构对伪连续动脉自旋标记的影响及流驱动绝热翻转的修正作用[J].中国医学物理学杂志,2021,38(9):1113-1118.[doi:10.3969/j.issn.1005-202X.2021.09.012]
　YUAN Weiwen,JIANG Guihua,et al.Effects of vascular tortuosities on pseudo-continuous arterial spin labeling and correctioneffects of flow-driven adiabatic inversion[J].Chinese Journal of Medical Physics,2021,38(9):1113-1118.[doi:10.3969/j.issn.1005-202X.2021.09.012]
点击复制

血管迂曲结构对伪连续动脉自旋标记的影响及流驱动绝热翻转的 修正作用()
分享到：

《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]

卷:
38卷
期数:
2021年第9期
页码:
1113-1118
栏目:
医学影像物理
出版日期:
2021-09-26

文章信息/Info

Title:
Effects of vascular tortuosities on pseudo-continuous arterial spin labeling and correction effects of flow-driven adiabatic inversion
文章编号:
1005-202X（2021）09-1113-06
作者:
袁伟文1; 2; 江桂华2; 罗泽斌1
1. 广东医科大学第一临床医学院，广东湛江524023；2. 广东省第二人民医院影像科，广东广州510020
Author(s):
YUAN Weiwen1;  2;  JIANG Guihua2;  LUO Zebing1
1. the First School of Clinical Medical, Guangdong Medical University, Zhanjiang 524023, China 2. Department of Imaging, Guangdong Second Provincial General Hospital, Guangzhou 510020, China
关键词:
伪连续动脉自旋标记; 血管迂曲结构; 流驱动绝热翻转
Keywords:
pseudo-continuous arterial spin label vascular tortuosity flow-driven adiabatic inversion
分类号:
R318；R445.2
DOI:
10.3969/j.issn.1005-202X.2021.09.012
文献标志码:
A
摘要:
探讨血管迂曲结构对伪连续动脉自旋标记序列（PCASL）的影响以及标记所用流驱动绝热翻转对该影响的修 正作用。方法：所有受检者均进行两次默认及两次修改方案PCASL扫描。根据血管迂曲结构与标记层面的几何关系将受 检者分为控制组（标记层面交于血管笔直处）与实验组（标记层面交于血管迂曲处）。两次修改方案PCASL分别将标记层面 距离增大为95与100 mm，以避让血管迂曲结构。比较各组受检者4次PCASL的测量结果差异。建立绝热翻转数学模型， 分析其技术原理特点对PCASL的作用。结果：两组的第二次默认方案、第一次修改方案的测量结果均与第一次默认方案无 统计学差异（P>0.05）。两组的第二次修改方案的测量结果均与第一次默认方案有统计学差异（P<0.05），且实验组下降趋势较 控制组明显。结论：流驱动绝热翻转的血液位移依赖性以及绝热性是PCASL稳健性、适用性与可重复性的技术基础。位于 标记层面内部与多次穿行于标记层面的血管迂曲结构所造成的影响可被流驱动绝热翻转修正，对PCASL的测量结果无实 际干扰。位于标记层面与成像区域间的血管迂曲结构可因T1效应导致PCASL的测量结果低于真实值。
Abstract:
Objective To investigate the effects of vascular tortuosities on the pseudo-continuous artery spin labeling (PCASL) and the correction effects of flow-driven adiabatic inversion used for labeling. Methods All subjects underwent 4 PCASL scans, including 2 default and 2 modified protocols, and the subjects were divided into control group (the labeling plane intersected at straight parts of vessels) and experimental group (the labeling plane intersected at vascular tortuosities) according to the geometric relationships between the labeling plane and vascular tortuosities. The 2 modified protocols increased the labeling plane distance to 95 and 100 mm, respectively, for avoiding vascular tortuosities. The differences in the PCASLmeasurement results in each group were compared and statistically analyzed.Amathematical model of adiabatic inversion was also established to analyze the effects of the technical principles of flow-driven adiabatic inversion on PCASL. Results The measurement results of the second default and the first modified protocol of the two groups were not statistically different from those of the first default protocol (P>0.05). However, the measurement results of the second modified protocol in both groups were statistically different from those of the first default protocol (P<0.05), and experimental group had a more obvious downward trend than control group. Conclusion The robustness, applicability and repeatability of PCASL are dependent on the blood displacement dependence and adiabaticity of flowdriven adiabatic inversion. The effects caused by vascular tortuosities located inside the labeling plane and those passing through the labeling plane multiple times can be corrected by flow-driven adiabatic inversion, thus there is no actual interference with the PCASL measurement results. The vascular tortuosities between the labeling plane and the imaging area may lower the PCASL measurement results due to T1 effect.

备注/Memo

备注/Memo:
【收稿日期】2021-03-09 【基金项目】国家自然科学基金（81771807） 【作者简介】袁伟文，硕士，放射技师，研究方向：磁共振成像原理，E-mail: 1619005472@qq.com 【通信作者】江桂华，博士，教授，研究方向：中枢神经系统影像，E-mail: 13828472201@163.com
更新日期/Last Update: 2021-09-27