[1]刘悦宁,庄伟,张海生,等.基于微波的多通道脑损伤检测系统性能研究与分析[J].中国医学物理学杂志,2020,37(9):1175-1180.[doi:10.3969/j.issn.1005-202X.2020.09.018]
　LIU Yuening,ZHUANG Wei,ZHANG Haisheng,et al.Performance evaluation and analysis of multichannel brain injury detection system based onmicrowave[J].Chinese Journal of Medical Physics,2020,37(9):1175-1180.[doi:10.3969/j.issn.1005-202X.2020.09.018]
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基于微波的多通道脑损伤检测系统性能研究与分析()
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《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]

卷:
37
期数:
2020年第9期
页码:
1175-1180
栏目:
医学人工智能
出版日期:
2020-09-25

文章信息/Info

Title:
Performance evaluation and analysis of multichannel brain injury detection system based on microwave
文章编号:
1005-202X（2020）09-1175-06
作者:
刘悦宁; 庄伟; 张海生; 赵双琳; 陈明生; 秦明新
陆军军医大学生物医学工程与影像医学系电子工程学教研室，重庆400038
Author(s):
LIU Yuening;  ZHUANG Wei;  ZHANG Haisheng;  ZHAO Shuanglin;  CHEN Mingsheng;  QIN Mingxin
Teaching and Research Section of Electronic Engineering, Department of Biomedical Engineering and Imaging Medicine, Army Medical University, Chongqing 400038, China
关键词:
颅脑损伤; 微波检测; 院前救治; 相位差; 敏感性
Keywords:
traumatic brain injury microwave test pre-hospital treatment phase difference sensitivity
分类号:
R318.6
DOI:
10.3969/j.issn.1005-202X.2020.09.018
文献标志码:
A
摘要:
目的：基于微波检测原理，研发一种可用于院前快速诊断脑损伤的多通道检测系统，并通过物理模拟实验分析系统 的敏感性。方法：该系统主要由矢量网络分析仪、8 天线阵列和多路复用开关组成。以不同浓度的生理盐水分别模拟具 有不同电导率的血液、脑脊液、白质和灰质，利用自制的微波检测系统分别测量4 种模拟液在不同体积（0~10 mL）下S21 相位值，每次测量重复4次，最后利用Matlab和SPSS 20.0软件进行统计学分析。结果：在1~3 GHz扫描频率下，检测系统 各通道对4种模拟液的S21相位测量值均随频率的增加而减小；在2.20 GHz和2.85 GHz两个特征频点，所有检测通道对 模拟液体积变化的敏感性均具有统计学意义（P<0.05）。在2.20 GHz 时，9 通道敏感性最高，此时S21 相位与体积呈负相 关；在2.85 GHz时，4通道敏感性最高，此时S21相位与体积呈正相关。Friedman M检验结果显示4种不同电导率模拟液 的S21相位值的差异具有统计学意义（P<0.05）。结论：该检测系统可以实现对同一电导率不同体积以及不同电导率模拟 液之间的区分。
Abstract:
Objective To develop a multichannel detection system based on microwave for the rapid pre-hospital diagnosis of traumatic brain injuries, and to analyze the system sensitivity by physical simulation experiment. Methods The system mainly consists of vector network analyzer, 8-antenna array and multiplexing switch. Different concentrations of physiological saline were used to simulate blood, cerebrospinal fluid, white matter and gray matter which had different electrical conductivities. The S21 phase values of 4 simulated solutions with different volumes (0-10 mL) were measured by a self-made microwave detection system. Each measurement was repeated 4 times. Finally, Matlab and SPSS 20.0 software were used for statistical analysis. Results At scanning frequency of 1-3 GHz, the S21 phase values of 4 simulated solutions measured by each channel of the detection system were decreased with the increase of frequency. At the two characteristic frequency points of 2.20 GHz and 2.85 GHz, the sensitivity of all detection channels to the volume changes of the simulated solutions was statistically significant (P<0.05). At the frequency of 2.20 GHz, the sensitivity of channel 9 was the highest, and the S21 phase had a negative correlation with volume and at the frequency of 2.85 GHz, the sensitivity of channel 4 was the highest, and the S21 phase was positively correlated with volume. The results of Friedman M test showed that there were statistical differences in the S21 phase values of 4 simulated solutions having different electrical conductivities (P<0.05). Conclusion The detection system can be used to distinguish the simulated solutions which have same electrical conductivity and different volumes, and to differentiate various simulated solutions having different electrical conductivities.

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备注/Memo

备注/Memo:
【收稿日期】2020-03-15 【基金项目】国家自然科学基金（61801483）；陆军装备部军内科研课 题（LJ2018B020152） 【作者简介】刘悦宁，硕士研究生，E-mail: liuyn_1224@163.com 【通信作者】秦明新，教授，博士生导师，E-mail: 346709149@qq.com； 陈明生，副教授，硕士生导师，E-mail: chenms83@163.com （秦明新与陈明生为共同通信作者）
更新日期/Last Update: 2020-09-25