[1]高峰,曹璐璐,羊奕伟,等.基于PARTER开展肿瘤Flash-RT研究——设计及计算[J].中国医学物理学杂志,2020,37(9):1081-1087.[doi:10.3969/j.issn.1005-202X.2020.09.001]
 GAO Feng,CAO Lulu,YANG Yiwei,et al.Design and calculation of Flash-RT based on PARTER[J].Chinese Journal of Medical Physics,2020,37(9):1081-1087.[doi:10.3969/j.issn.1005-202X.2020.09.001]
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基于PARTER开展肿瘤Flash-RT研究——设计及计算()
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《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]

卷:
37
期数:
2020年第9期
页码:
1081-1087
栏目:
医学人工智能
出版日期:
2020-09-25

文章信息/Info

Title:
Design and calculation of Flash-RT based on PARTER
文章编号:
1005-202X(2020)09-1081-07
作者:
高峰1曹璐璐14羊奕伟2杜小波1戴堂知1吴岱3
1. 绵阳市中心医院,四川绵阳621000;2. 中国工程物理研究院核物理与化学研究所,四川绵阳621900;3. 中国工程物理研究院 应用电子研究所,四川绵阳621900;4. 川北医学院,四川南充637000
Author(s):
GAO Feng1 CAO Lulu1 4 YANG Yiwei2 DU Xiaobo1 DAI Tangzhi1 WU Dai3
1. Mianyang Central Hospital, Mianyang 621000, China 2. Institute of Nuclear Physics and Chemistry, China Academy of Engineering Physics, Mianyang 621900, China 3. Institute of Applied Electronics, China Academy of Engineering Physics, Mianyang 621900, China 4. North Sichuan Medical College, Nanchong 637000, China
关键词:
闪光放疗PARTER放射剂量蒙特卡罗模拟
Keywords:
Flash radiotherapy platform for advanced radiotherapy research radiotherapy dose Monte Carlo simulation
分类号:
R318;RR811.1
DOI:
10.3969/j.issn.1005-202X.2020.09.001
文献标志码:
A
摘要:
闪光放疗(Flash-RT)是近年来国际肿瘤放疗研究的前沿科技和研究热点,其使用超大剂量率(通常大于100 Gy/s) 在极短时间(1~50 ms)内将全部放疗剂量注入靶区。研究发现其对正常组织体现出更小的损伤,同时可呈量级地降低放 疗时间。中国工程物理研究院太赫兹自由电子激光装置上的超导电子加速器可提供最高平均流强5 mA的6~8 MeV电 子束流,基于它的先进放疗研究平台(PARTER)具有Flash-RT研究的潜力。本文首次介绍PARTER及详细的Flash-RT专 用靶和准直器物理设计方案,并给出关键参数的蒙特卡罗模拟计算结果。根据设计,平台上生物样品内注入的最高剂量 率达2 000 Gy/s,剂量注入时间从μs到百ms持续可调,100 Gy/s以上剂量率覆盖深度超过20 cm,符合Flash-RT研究要求。 文中给出了详细的计算过程和结果分析,以提供给之后在PARTER上开展Flash-RT实验研究作为基本参考数据。
Abstract:
Flash radiotherapy (Flash-RT) which is an international cutting-edge technology and hotspot in the domain of tumor radiotherapy in recent years delivers all the treatment dose into the target area in an ultra-short time (about 1-50 ms) at ultra-high dose rate (usually >100 Gy/s). Various researches revealed that Flash-RT could significantly reduce the time of radiotherapy and bring less damage to normal tissues. The superconducting electron accelerator of the CTFEL facility in China Academy of Engineering Physics can produce 6-8 MeV electron beam up to 5 mA in average current, and the platform for advanced radiotherapy research (PARTER) based on the superconducting electron accelerator should be a suitable platform for Flash-RT research. Herein PARTER and the detailed design schemes of Flash-RT specific targets and collimators are firstly introduced. According to Monte Carlo simulation, the maximum dose rate for the biological samples on the platform was up to 2 000 Gy/s, and the exposure time was continuously adjustable from μs to 100 ms, and the coverage depth for dose rate larger than 100 Gy/s was more than 20 cm, which meet the requirements of Flash-RT research. The detailed calculation process and result analysis are described for providing some basic reference data for the following Flash-RT experiments which are carried out on PARTER.

备注/Memo

备注/Memo:
【收稿日期】2020-04-14 【基金项目】国家自然科学基金(11790321,11675155);中国工程物理 研究院院长基金(YZLX 2017003) 【作者简介】高峰,博士,副主任医师,主要从事消化道肿瘤放疗研究, E-mail: edna_9999@163.com 【通信作者】羊奕伟,博士,助理研究员,主要从事核技术及医学物理研 究,E-mail: winfield1920@126.com
更新日期/Last Update: 2020-09-25