[1]吴文秀,江桂华,徐志锋,等.鼻咽癌3D pCASL与Ki-67指数相关性及临床分期价值[J].中国医学物理学杂志,2020,37(2):190-194.[doi:DOI:10.3969/j.issn.1005-202X.2020.02.011]
　WU Wenxiu,,et al.Correlation between 3D pCASL of nasopharyngeal carcinoma with Ki-67 index and its value in clinical staging[J].Chinese Journal of Medical Physics,2020,37(2):190-194.[doi:DOI:10.3969/j.issn.1005-202X.2020.02.011]
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鼻咽癌3D pCASL与Ki-67指数相关性及临床分期价值()
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《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]

卷:
37
期数:
2020年第2期
页码:
190-194
栏目:
医学影像物理
出版日期:
2020-02-25

文章信息/Info

Title:
Correlation between 3D pCASL of nasopharyngeal carcinoma with Ki-67 index and its value in clinical staging
文章编号:
1005-202X（2020）02-0190-05
作者:
吴文秀1; 2; 3; 江桂华1; 2; 徐志锋3; 潘爱珍3; 高明勇3; 周新韩3
1.南方医科大学第二临床医学院， 广东 广州 510282； 2.广东省第二人民医院影像科， 广东 广州 510317； 3.佛山市第一人民医院（中山大学附属佛山医院）影像科， 广东 佛山 528000
Author(s):
WU Wenxiu1;  2;  3;  JIANG Guihua1;  2;  XU Zhifeng3;  PAN Aizhen3;  GAO Mingyong3;  ZHOU Xinhan3
1. the Second Clinical Medical College of Southern Medical University, Guangzhou 510282, China; 2. Department of Imaging, Guangdong Second Provincial General Hospital, Guangzhou 510317, China; 3. Department of Imaging, Foshan First People’s Hospital (Foshan Hospital Affiliated to Sun Yat-sen University), Foshan 528000, China
关键词:
鼻咽癌; 磁共振成像; 三维动脉自旋标记; Ki-67
Keywords:
Keywords: nasopharyngeal carcinoma;  magnetic resonance imaging;  three-dimensional pseudo-continuous arterial spin labeling;  Ki-67
分类号:
R739.62；R445.2
DOI:
DOI:10.3969/j.issn.1005-202X.2020.02.011
文献标志码:
A
摘要:
目的：探讨鼻咽癌三维动脉自旋标记（3D pCASL）与Ki-67指数的相关性及其对临床分期的价值。方法：收集病理证实的鼻咽癌首诊患者48例，其中36例经免疫组化检测Ki-67指数，并对患者以T、N及临床分期分为低、高级别组。所有患者均行鼻咽部MR平扫及增强和3D-ASL序列扫描，并测量肿瘤实质内的血流图平均值（BFmean）、最小值（BFmin）及最大值（BFmax），利用秩和检验比较高、低级别组间ASL的3个定量参数的差异。分析3个定量参数与Ki-67之间相关性。结果：T、N及临床分期的高级别组BFmean、BFmax及BFmin值均高于低级别组；Ki-67指数与BFmax显著相关（r=0.408, P=0.014），具有统计学意义（P<0.05）。结论：3D pCASL作为一种无创的功能磁共振灌注成像，可以评估鼻咽癌的血流灌注信息；BFmax可以评价鼻咽癌的增殖程度，有利于评估鼻咽癌患者预后。
Abstract:
Abstract: Objective To explore the correlation between the parameters derived from three-dimensional pseudo-continuous arterial spin labeling (3D pCASL) of nasopharyngeal carcinoma (NPC) with Ki-67 index and discuss its value in clinical staging. Methods Forty-eight cases with an initial diagnosis of NPC confirmed by pathology were collected, among which 36 cases were assessed by immunohistochemistry with Ki-67 index. The patients were grouped into T, N and clinical stages and then divided into low- and high-grade groups. All patients were given magnetic resonance plain and enhanced nasopharyngeal scans and 3D-ASL sequence scan. The mean value (BFmean), minimum value (BFmin) and maximum value (BFmax) of blood flow in tumor parenchyma were measured, and the differences in the 3 quantitative parameters of ASL between high- and low-grade groups were compared with rank sum test. Finally, the correlations between 3 quantitative parameters and Ki-67 index were analyzed. Results BFmean, BFmax and BFmin in the high-grade groups of T, N and clinical stages were higher than those in the low-grade groups. Ki-67 index was significantly correlated with BFmax (r=0.408, P=0.014), with statistical significance (P<0.05). Conclusion As a non-invasive functional magnetic resonance perfusion imaging, 3D pCASL can be used to evaluate the blood perfusion of NPC. Moreover, BFmax can be used to assess the degree of NPC proliferation, which is helpful to evaluate the prognosis of NPC patients.

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备注/Memo

备注/Memo:
【收稿日期】2019-09-04 【基金项目】广东省自然科学基金（2014A030310276）；佛山市科技局医学科研项目（2016AB002371） 【作者简介】吴文秀，在读硕士，主治医师，研究方向：头颈部影像诊断，E-mail: 945349163@qq.com 【通信作者】江桂华，博士，主任医师，E-mail: jiangguihua1970@163.com
更新日期/Last Update: 2020-03-03