[1]彭清河,叶芝甫,王志光,等.基部计划剂量补偿优化方法在肺癌调强放疗计划中的应用[J].中国医学物理学杂志,2020,37(8):1000-1004.[doi:DOI:10.3969/j.issn.1005-202X.2020.08.012]
 PENG Qinghe,YE Zhifu,et al.Application of base dose plan compensation optimization method in intensity-modulated radiotherapy for lung cancer[J].Chinese Journal of Medical Physics,2020,37(8):1000-1004.[doi:DOI:10.3969/j.issn.1005-202X.2020.08.012]
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基部计划剂量补偿优化方法在肺癌调强放疗计划中的应用()
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《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]

卷:
37
期数:
2020年第8期
页码:
1000-1004
栏目:
医学放射物理
出版日期:
2020-08-27

文章信息/Info

Title:
Application of base dose plan compensation optimization method in intensity-modulated radiotherapy for lung cancer
文章编号:
1005-202X(2020)08-1000-05
作者:
彭清河12叶芝甫3王志光3彭应林1
1.中山大学肿瘤防治中心/华南肿瘤学国家实验室/肿瘤医学协同创新中心, 广东 广州510060; 2.南方医科大学生物医学工程学院, 广东 广州 510515; 3.广西中医药大学第一附属医院, 广西 南宁530000
Author(s):
PENG Qinghe1 2 YE Zhifu3 WANG Zhiguang3 PENG Yinglin1
1. Department of Radiation Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in Southern China, Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, China 2. School of Biomedical Engineering, Southern Medical University, Guangzhou 510515, China 3. the First Affiliated Hospital of Guangxi University of Chinese Medicine, Nangning 530000, China
关键词:
肺癌调强放射治疗剂量补偿优化基部计划剂量补偿冷热点控制
Keywords:
Keywords: lung cancer intensity-modulated radiotherapy dose compensation optimization base dose plan compensation hot and cold spot control
分类号:
R734.2;R815.6
DOI:
DOI:10.3969/j.issn.1005-202X.2020.08.012
文献标志码:
A
摘要:
【摘要】目的:比较基部计划剂量补偿(BDPC组)和冷热点控制(HCSC组)两种计划优化方法得到的肺癌调强放疗计划的剂量学差异。方法:选取13例肺癌患者,采用相同优化条件分别设计BDPC和HCSC两组放疗计划。计划处方:PGTV为60 Gy/26 f、PCTV为50 Gy/26 f。比较两组肿瘤靶区和危及器官的各项剂量评价参数、计划时间和机器跳数(MU)。采用配对t检验或非参数检验进行统计学分析。结果:BDPC组相对于HCSC组有较好的靶区CI(PGTV:0.66±0.14 vs 0.58±0.15, P<0.05;PCTV:0.61±0.28 vs 0.57±0.27, P=0.066)和HI (PGTV:0.08±0.02 vs 0.11±0.05, P<0.05;PCTV:0.23±0.03 vs 0.27±0.03, P<0.05);前者较后者重要危及器官的剂量低,食管的Dmax、双肺的V5 Gy和V20 Gy分别为(59.92±2.87) Gy vs (62.09±3.34) Gy、49%±18% vs 51%±11%和22%±9 % vs 24%±7%,P值均小于0.05。结论:对于肺癌调强放疗计划,BDPC优化方法得到的计划剂量分布较HCSC优化方法更优,能保证靶区覆盖的同时降低重要危及器官的受照剂量,可在临床上推广应用。
Abstract:
Abstract: Objective To compare the dosimetric differences between base dose plan compensation (BDPC group) and hot and cold spot control (HCSC group) in intensity-modulated radiotherapy for lung cancer. Methods Thirteen patients with lung cancer were enrolled in the study. For each patient, BDPC plan and HCSC plan were designed with the same optimization criteria. The prescription dose were 60 Gy in 26 fractions delivered to PGTV and 50 Gy in 26 fractions delivered to PCTV. The parameters for the dose evaluation of target areas and organs-at-risk, planning time and monitor units were compared, and paired t-test or non-parametric test was used for statistical analysis. Results Compared with HCSC group, BDPC group had higher CI (PGTV: 0.66±0.14 vs 0.58±0.15, P<0.05 PCTV: 0.61±0.28 vs 0.57±0.27, P=0.066) and lower HI (PGTV: 0.08±0.02 vs 0.11±0.05, P<0.05 PCTV: 0.23±0.03 vs 0.27±0.03, P<0.05). BDPC group also had advantages in organs-at-risk sparing. The Dmax of esophagus as well as the V5 Gy and V20 Gy of both lungs in BDPC group were significantly lower than those in HCSC group [(59.92 ±2.87) Gy vs (62.09 ±3.34) Gy, 49%±18% vs 51%±11 % and 22%±9% vs 24% ±7%, respectively all P<0.05]. Conclusion For intensity-modulated radiotherapy for lung cancer, the dose profile obtained by BDPC optimization method is superior to that obtained by HCSC optimization method. BDPC optimization method can not only ensure the target coverage, but also lower the irradiation doses to organs-at-risk, worthy of application and popularization in clinic.

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备注/Memo

备注/Memo:
【收稿日期】2020-02-11 【作者简介】彭清河,硕士,研究方向:放疗物理,E-mail: pengqh@sysucc.org.cn 【通信作者】彭应林,助理研究员,研究方向:肿瘤放射治疗物理学,E-mail: pengyl@sysucc.org.cn
更新日期/Last Update: 2020-08-27