[1]谢东东,程永欣,王宪福,等.原发性失眠患者大脑背外侧前额叶的异常静息态功能连接[J].中国医学物理学杂志,2020,37(5):574-578.[doi:10.3969/j.issn.1005-202X.2020.05.008]
　XIE Dongdong,CHENG Yongxin,WANG Xianfu,et al.Abnormal resting-state functional connectivity of the dorsolateral prefrontal lobe in patientswith primary insomnia[J].Chinese Journal of Medical Physics,2020,37(5):574-578.[doi:10.3969/j.issn.1005-202X.2020.05.008]
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原发性失眠患者大脑背外侧前额叶的异常静息态功能连接()
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《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]

卷:
37
期数:
2020年第5期
页码:
574-578
栏目:
医学影像物理
出版日期:
2020-05-25

文章信息/Info

Title:
Abnormal resting-state functional connectivity of the dorsolateral prefrontal lobe in patients with primary insomnia
文章编号:
1005-202X（2020）05-0574-05
作者:
谢东东1; 程永欣1; 王宪福1; 刘畅1; 崔永婷1; 田时雨1; 刘波2; 喻大华1
1. 内蒙古科技大学信息工程学院，内蒙古包头014010；2. 内蒙古科技大学包头医学院第一附属医院，内蒙古包头014010
Author(s):
XIE Dongdong1;  CHENG Yongxin1;  WANG Xianfu1;  LIU Chang1;  CUI Yongting1;  TIAN Shiyu1;  LIU Bo2;  YU Dahua1
1. School of Information Engineering, Inner Mongolia University of Science and Technology, Baotou 014010, China 2. The First Affiliated Hospital of Baotou Medical College, Inner Mongolia University of Science and Technology, Baotou 014010, China
关键词:
原发性失眠; 背外侧前额叶; 静息态功能连接
Keywords:
primary insomnia dorsolateral prefrontal lobe resting-state functional connectivity
分类号:
R318；R749.99
DOI:
10.3969/j.issn.1005-202X.2020.05.008
文献标志码:
A
摘要:
目的：利用功能连接方法观察原发性失眠患者静息态下的背外侧前额叶的异常功能连接。方法：采集33 例原 发性失眠患者以及33 例年龄、性别和受教育程度相匹配的健康对照的功能磁共振图像，以背外侧前额叶为感兴趣区 域，与全脑其他体素进行功能连接分析，得到两组之间功能连接的差异脑区，再对异常功能连接脑区与临床的量表分 数做相关分析。结果：与对照组相比，发现失眠患者左侧背外侧前额叶与左侧枕下回、右侧枕下回、右侧枕中回、右侧 颞叶、左侧额中回，左侧额下回以及右侧梭状回之间的功能连接增强（P<0.05，体素簇个数≥100，FDR校正），与左侧前 扣带皮层、右侧海马旁回、右侧脑岛、右侧背外侧额上回、右侧顶上回、右侧中央后回以及右侧中央前回之间的功能连 接减弱（P<0.05，体素簇个数≥100，FDR校正）。并且左侧背外侧前额叶与左侧枕叶下回的功能连接值与睡眠状况自评 量表分数成正相关（P=0.035）。结论：原发性失眠患者背外侧前额叶与大脑多个脑区出现异常的功能连接，可能为理 解原发性失眠患者的神经机制提供一些新的影像学依据。
Abstract:
Objective: To explore the abnormal of functional connectivity (FC) of dorsolateral prefrontal lobe in patients with primary insomnia using FC analysis in resting-state functional magnetic resonance imaging ( fMRI). Method: Totally 33 primary insomnia patients and 33 age-, gender- and education -matched healthy control subjects underwent resting-state fMRI. The dorsolateral prefrontal lobe were selected as ROIs, and FC analysis with other voxels in the brain to obtain abnormal FC between the two groups. Then relationships between abnormal FC and clinical scale scores were investigated with Pearson’s correlation analysis. Result: Compared with the healthy control group, The FC between the left dorsolateral prefrontal lobe and the left inferior occipital gyrus, the right inferior occipital gyrus, the right middle occipital gyrus, the right temporal lobe, the right medial superior frontal gyrus and the right fusiform gyrus were enhanced, the functional connections with the left anterior cingulate cortex, the right parahippocampal gyrus, the right insula, the right dorsolateral superior frontal gyrus, the right superior parietal gyrus, the right postcentral gyrus and the right precentral gyrus were weakened in primary insomnia （p<0.05, number of voxel≥100, FDR correction）. And the FC values of left dorsolateral prefrontal lobe and left inferior occipi tal lobe were positively correlated with SRSS scores（p=0.035）. conclusion: FC is abnormal between the dorsolateral prefrontal lobe and multiple brain regions in primary insomnia patients, it may provide some new imaging evidence for understanding the neurological mechanism of primary insomnia ．

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[1]冯正权,马国重,乐发国,等.原发性失眠与抑郁症伴发失眠患者觉醒水平脑电频谱及复杂度分析比较研究[J].中国医学物理学杂志,2013,30(06):4553.[doi:10.3969/j.issn.1005-202X.2013.06.020]
[2]许光,吴宏,江桂华,等. 原发性失眠患者大脑额顶网络的异常功能连接[J].中国医学物理学杂志,2018,35(8):988.[doi:DOI:10.3969/j.issn.1005-202X.2018.08.023]
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[5]田时雨,薛婷,董芳,等.基于弥散张量成像的原发性失眠患者大脑白质变化[J].中国医学物理学杂志,2021,38(1):51.[doi:DOI:10.3969/j.issn.1005-202X.2021.01.009]
　TIAN Shiyu,XUE Ting,DONG Fang,et al.Primary insomniacs white matter abnormalities based on diffusion tensor imaging[J].Chinese Journal of Medical Physics,2021,38(5):51.[doi:DOI:10.3969/j.issn.1005-202X.2021.01.009]

备注/Memo

备注/Memo:
【收稿日期】2019-12-15 【基金项目】国家自然科学基金（81871430, 81871426, 61771266）；内蒙古自治区高等学校青年科技英才支持计划（NJYT-17-B11）；内蒙古自治区自 然科学基金（2019JQ07） 【作者简介】谢东东，硕士研究生，研究方向：医学图像处理，E-mail: 1554687114@qq.com 【通信作者】喻大华，博士，教授，研究方向：医学图像处理，E-mail: fmydh@imust.edu.cn
更新日期/Last Update: 2020-06-03