[1]马成华,张宇,景鹏举,等.流体剪切力对人牙周膜细胞作用的研究进展[J].中国医学物理学杂志,2020,37(7):908-911.[doi:DOI:10.3969/j.issn.1005-202X.2020.07.021]
 MA Chenghua,ZHANG Yu,JING Pengju,et al.Effects of fluid shear stress on human periodontal ligament cells: a review[J].Chinese Journal of Medical Physics,2020,37(7):908-911.[doi:DOI:10.3969/j.issn.1005-202X.2020.07.021]
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流体剪切力对人牙周膜细胞作用的研究进展()
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《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]

卷:
37
期数:
2020年第7期
页码:
908-911
栏目:
医学生物物理
出版日期:
2020-07-25

文章信息/Info

Title:
Effects of fluid shear stress on human periodontal ligament cells: a review
文章编号:
1005-202X(2020)07-0908-04
作者:
马成华张宇景鹏举李培武
兰州大学第二医院急救中心, 甘肃 兰州 730000
Author(s):
MA Chenghua ZHANG Yu JING Pengju LI Peiwu
Emergency Center, Lanzhou University Second Hospital, Lanzhou 730000, China
关键词:
流体剪切力牙周膜细胞信号通路细胞增殖细胞分化综述
Keywords:
Keywords: fluid shear stress periodontal ligament cell signaling pathway cell proliferation cell differentiation review
分类号:
R782.1;R318
DOI:
DOI:10.3969/j.issn.1005-202X.2020.07.021
文献标志码:
A
摘要:
为了明确流体剪切力对牙周膜细胞的作用以及为后续相关研究提供理论依据,通过查阅文献发现流体剪切力可通过miRNA-132/PI3K/mTOR信号通路、ERK/p38/JNK MAPK信号通路和Wnt/LEF-1信号通路促进牙周膜细胞成骨分化,此外,还可调控牙周膜细胞的增殖,抑制细胞的迁移,还可影响炎症因子COX-2的表达。未来可进一步研究流体剪切力对牙周膜细胞确切的增殖效应及其具体机制。
Abstract:
Abstract: The study aims to clarify the effects of fluid shear stress on periodontal ligament cells and provide a theoretical basis for subsequent related researches. By reviewing the related literatures, it is revealed that fluid shear stress can promote the osteogenic differentiation of periodontal ligament cells via miRNA-132/PI3K/mTOR signaling pathway, ERK/p38/JNK MAPK signaling pathway and Wnt/LEF-1 signaling pathway. In addition, fluid shear stress can also regulate the proliferation of periodontal ligament cells, inhibit cell migration, and affect the expression of inflammatory factor COX-2. In the future, the exact proliferation effect of fluid shear stress on periodontal ligament cells and its specific mechanism can be further studied.

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备注/Memo

备注/Memo:
【收稿日期】2020-02-18 【基金项目】国家自然科学基金(81672207) 【作者简介】马成华,从事颌面外科研究,E-mail: machenghua2019@sohu.com 【通信作者】李培武,主任医师,从事急诊医学研究,E-mail: lipeiwu 2019@sohu.com
更新日期/Last Update: 2020-07-28