[1]刘致滨,石锦平,张利文,等. 光子优化算法与逐级递进解析优化算法在鼻咽癌容积旋转调强计划的剂量学对比研究[J].中国医学物理学杂志,2019,36(8):872-876.[doi:DOI:10.3969/j.issn.1005-202X.2019.08.002]
　LIU Zhibin,SHI Jinping,ZHANG Liwen,et al. Dosimetric study on photon optimization algorithm and progressive resolution optimization algorithm in volumetric modulated arc therapy plan for nasopharyngeal carcinoma[J].Chinese Journal of Medical Physics,2019,36(8):872-876.[doi:DOI:10.3969/j.issn.1005-202X.2019.08.002]
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 光子优化算法与逐级递进解析优化算法在鼻咽癌容积旋转调强计划的剂量学对比研究()
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《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]

卷:
36卷
期数:
2019年第8期
页码:
872-876
栏目:
医学放射物理
出版日期:
2019-08-26

文章信息/Info

Title:
 Dosimetric study on photon optimization algorithm and progressive resolution optimization algorithm in volumetric modulated arc therapy plan for nasopharyngeal carcinoma
文章编号:
1005-202X（2019）08-0872-05
作者:
 刘致滨; 石锦平; 张利文; 谢秋英; 滕建建; 李盈辉
 佛山市第一人民医院（中山大学附属佛山医院）肿瘤中心放疗科， 广东 佛山 528000
Author(s):
 LIU Zhibin;  SHI Jinping;  ZHANG Liwen;  XIE Qiuying;  TENG Jianjian;  LI Yinghui
 Department of Radiation Oncology, Cancer Center, the First People’s Hospital of Foshan (Affiliated Foshan Hospital of Sun Yat-sen University), Foshan 528000, China
关键词:
鼻咽癌; 容积旋转调强; 光子优化算法; 逐级递进解析优化算法; 剂量学分析
Keywords:
 ; Keywords: nasopharyngeal carcinoma;  volumetric modulated arc therapy;  photon optimization algorithm;  progressive resolution optimization;  dosimetric analysis
分类号:
R811.1；R739.6；R312
DOI:
DOI:10.3969/j.issn.1005-202X.2019.08.002
文献标志码:
A
摘要:
 目的：比较Eclipse计划系统中光子优化（PO）算法与逐级递进解析优化（PRO）算法在鼻咽癌容积旋转调强放射治疗计划中的剂量学差异。方法：选取20例接受容积旋转调强放射治疗的鼻咽癌患者，CT图像扫描后勾画靶区和危及器官，分别用PO算法和PRO算法设计两种RapidArc计划，即PO计划与PRO计划，并比较两种计划的剂量学特性、机器跳数、gamma通过率和计划优化的效率。结果：两种计划的PGTVnx的D2%、Dmean、D98%、靶区覆盖率、适形度指数和均匀性指数均相差不大（P>0.05），PO计划在PGTVnd、PTV1、PTV2的D98%和Dmean均高于PRO计划（P<0.05）。左右晶体、左右腮腺、左右颞叶、左右视神经的受量两种计划无统计学差异（P>0.05）；但PRO计划的脑干D1%和Dmean、脊髓D1%及喉Dmean均低于PO计划，且有统计学差异（P<0.05）。两种计划的gamma通过率均能满足治疗的要求，且PO计划的gamma通过率（3 mm/3%和2 mm/3%）均好于PRO计划，分别为（99.13±0.81）%和（97.77±1.31）%、（98.62±0.84）%和（96.84±1.31）%。PRO计划平均机器跳数增至PO计划的1.13倍（P=0.000），在计划优化效率上PRO计划优化平均耗时为PO计划的1.66倍（P=0.000）。结论：PO计划和PRO计划均能满足临床的要求。在靶区剂量分布上，PO计划略有优势；但在脑干、脊髓和喉咙的保护上，PRO计划更有优势。PO算法产生的计划能够减少机器跳数，大大减少计划优化耗时，推荐使用PO算法作为鼻咽癌容积旋转调强计划的优化算法。
Abstract:
Abstract: Objective To compare the dosimetric differences between photon optimization (PO) algorithm and progressive resolution optimization (PRO) algorithm of Eclipse planning system in volumetric modulated arc therapy plan for nasopharyngeal carcinoma. Methods The CT images of 20 patients who were treated with radiotherapy for nasopharyngeal carcinoma were imported into the planning system, and then target areas and organs-at-risk were delineated. Two different RapidArc plans were generated with different algorithm, namely PO algorithm and PRO algorithm. The dosimetric distributions, monitor units, gamma passing rates and optimization time of the two kinds for treatment plans were compared. Results No significant difference was found between PO plan and PRO plan in the D2%, Dmean, D98%, target coverage, conformity index and homogeneity index of PGTVnx (P>0.05). However, the D98% and Dmean of PGTVnd, PTV1 and PTV2 in PO plan were higher than those in PRO plan (P<0.05). There was no statistical difference between two plans in the doses of bilateral lenses, bilateral parotid glands, bilateral temporal lobes and bilateral optic nerves (P>0.05). Compared with those in PO plan, the D1% and Dmean of brainstem, D1% of spinal cord and Dmean of larynx were lower in PRO plan, with statistical differences (P<0.05). The gamma passing rates of both two plans met treatment requirements, and the gamma passing rates (3 mm/3% and 2 mm/3%) of PO were (99.13±0.81)% and (97.77±1.31)%, respectively, superior to (98.62±0.84)% and (96.84±1.31)% of PRO plan. Moreover, the average monitor units of PRO plan were  increased to 1.13 times of that of PO plan (P=0.000), and the average optimization time was 1.66 times of that of PO plan (P=0.000). Conclusion Both of PO plan and PRO plan can qualify clinical requirements. PO plan is advantageous in the dose distribution of target area, but PRO plan has more advantages in the protection of brainstem, spinal cord and larynx. PO algorithm is recommended for volumetric modulated arc therapy plan for nasopharyngeal carcinoma, because the plan generated by PO algorithm can greatly reduce monitor units and shorten optimization time.

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备注/Memo

备注/Memo:
 【收稿日期】2019-02-22
【基金项目】国家重点研发计划（2017YFC0113205）
【作者简介】刘致滨，硕士，研究方向：放疗物理，E-mail: lzbin2008@sina.com
【通信作者】石锦平，主任技师，研究方向：放疗计划设计与质量控制，E-mail: rath55@126.com
更新日期/Last Update: 2019-08-26