[1]蔡春雅,戴振晖,张白霖,等. 基于Calypso电磁实时跟踪系统的4D剂量验证[J].中国医学物理学杂志,2019,36(5):513-516.[doi:DOI:10.3969/j.issn.1005-202X.2019.05.004]
　CAI Chunya,DAI Zhenhui,ZHANG Bailin,et al. 4D dose verification based on Calypso electromagnetic real-time tracking system[J].Chinese Journal of Medical Physics,2019,36(5):513-516.[doi:DOI:10.3969/j.issn.1005-202X.2019.05.004]
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 基于Calypso电磁实时跟踪系统的4D剂量验证()
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《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]

卷:
36卷
期数:
2019年第5期
页码:
513-516
栏目:
医学放射物理
出版日期:
2019-05-25

文章信息/Info

Title:
 4D dose verification based on Calypso electromagnetic real-time tracking system
文章编号:
1005-202X（2019）05-0513-04
作者:
 蔡春雅; 戴振晖; 张白霖; 朱琳; 招什武; 杨耕; 朱远湖; 李飞; 王学涛
 广州中医药大学第二附属医院， 广东 广州 510006
Author(s):
 CAI Chunya;  DAI Zhenhui;  ZHANG Bailin;  ZHU Lin;  ZHAO Shiwu;  YANG Geng;  ZHU Yuanhu;  LI Fei;  WANG Xuetao
 CAI Chunya, DAI Zhenhui, ZHANG Bailin, ZHU Lin, ZHAO Shiwu, YANG Geng, ZHU Yuanhu, LI Fei, WANG Xuetao
关键词:
 ; 呼吸运动; 4D剂量验证; 实时跟踪; Calypso系统
Keywords:
 ; Keywords: respiratory motion;  4D dose verification;  real-time tracking;  Calypso system
分类号:
R312；TL72
DOI:
DOI:10.3969/j.issn.1005-202X.2019.05.004
文献标志码:
A
摘要:
 目的：研究基于Calypso电磁实时跟踪系统的4D剂量验证的可行性，评估Calypso引导对运动靶区放疗剂量精度提高的有效性。方法：将5 cm×5 cm、10 cm×10 cm方野、直径d＝10 cm圆形野以及5例IMRT、5例VMAT放疗计划移植到Delta4三维剂量验证系统，使用自主呼吸运动平台搭载Delta4模体进行SI方向上周期（T）=5 s，振幅（A）＝±10 mm的往复运动，分别比较静态、动态无跟踪，以及使用Calypso实时跟踪系统运动阈值分别为±2、±3、±5 mm情况下Delta4实测的剂量分布和治疗计划系统剂量分布。结果：静态、动态测量Calypso运动阈值为±2、±3、±5 mm以及动态无跟踪时计划γ通过率的平均值分别为（97.5±2.4）%、（95.9±2.8）%、（93.9±3.8）%、（86.2±8.6）%、（65.0±11.1）%；与静态射野平均γ通过率比较，使用Calypso动态运动阈值为±2、±3 mm时γ通过率差异无统计学意义（P>0.05）, Calypso动态运动阈值为±5 mm与动态无跟踪时γ通过率差异具有统计学差异（P<0.05）。结论：对于胸腹部肿瘤患者，基于Calypso实时电磁跟踪，结合Delta4三维验证系统对运动靶区进行实时4D剂量验证是可行的，使用Calypso跟踪运动肿瘤放疗时，剂量精度有明显提高。
Abstract:
 Abstract: Objective To investigate the feasibility of 4D dose verification based on Calypso electromagnetic real-time tracking system and evaluate the effectiveness of using Calypso system to improve the accuracy of radiotherapy dose of motion targets. Methods The fields of 5 cm×5 cm and 10 cm×10 cm, a circle field of 10 cm in diameter, 5 cases of IMRT plans and 5 cases of VMAT plans were transplanted to Delta4 three-dimensional dose verification system, and the Delta4 phantom was placed on the self-developed respiratory motion stage to simulate the respiratory in SI direction. The period of the respiratory motion stage was set to 5 s and the amplitude was ±10 mm. Dose distributions obtained with Delta4 software under the static, dynamic non-tracking and Calypso tracking with the motion thresholds of ±2, ±3 and ±5 mm were compared with the dose distributions obtained with treatment planning system. Results The average gamma passing rates of the static, Calypso tracking with the motion thresholds of ±2, ±3 and ±5 mm, and dynamic non-tracking were (97.5±2.4)%, (95.9±2.8)%, (93.9±3.8)%, (86.2±8.6)% and (65.0±11.1) %, respectively. No significant difference was found in the gamma passing rates between static field and Calypso tracking with the motion thresholds of ±2 and ±3 mm (P>0.05). However, there was statistical difference between Calypso tracking with the motion threshold of ±5 mm and dynamic non-tracking (P<0.05). Conclusion For patients with thoracic and abdominal tumors, using the combination of Calypso electromagnetic real-time tracking system and Delta4 three-dimensional verification system to perform the real-time 4D dose verification of the motion targets is proved to be feasible. The dose accuracy is significantly improved while using Calypso tracking during radiotherapy.

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备注/Memo

备注/Memo:
 【收稿日期】2018-12-10
【基金项目】广东省科技厅自筹经费类项目（2017ZC0165）；广东省医学科研基金（A2019196）
【作者简介】蔡春雅，助理工程师，主要从事肿瘤放射物理工作，E-mail: Allison_c@163.com
【通信作者】王学涛，博士，主任技师，主要从事肿瘤放射物理工作，E-mail: wangxuetao0625@126.com
更新日期/Last Update: 2019-05-23