[1]吴凡,郎锦义,许敬辉,等.5种铅门X轴固定技术在鼻咽癌容积旋转调强放疗中的剂量学比较[J].中国医学物理学杂志,2020,37(2):133-137.[doi:DOI:10.3969/j.issn.1005-202X.2020.02.001]
 WU Fan,LANG Jinyi,XU Jinghui,et al.Dosimetric study of 5 fixed-jaw techniques in volumetric modulated arc therapy for nasopharyngeal carcinoma[J].Chinese Journal of Medical Physics,2020,37(2):133-137.[doi:DOI:10.3969/j.issn.1005-202X.2020.02.001]
点击复制

5种铅门X轴固定技术在鼻咽癌容积旋转调强放疗中的剂量学比较()
分享到:

《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]

卷:
37
期数:
2020年第2期
页码:
133-137
栏目:
医学放射物理
出版日期:
2020-03-03

文章信息/Info

Title:
Dosimetric study of 5 fixed-jaw techniques in volumetric modulated arc therapy for nasopharyngeal carcinoma
文章编号:
1005-202X(2020)02-0133-05
作者:
吴凡1郎锦义1许敬辉1袁佳薇2康盛伟1陈亚正1吴骏翔1
1.电子科技大学医学院附属肿瘤医院四川省肿瘤医院放疗中心/放射肿瘤学四川省重点实验室, 四川 成都 610041; 2.四川省科学城医院肿瘤科, 四川 绵阳621900
Author(s):
WU Fan1 LANG Jinyi1 XU Jinghui1 YUAN Jiawei2 KANG Shengwei1 CHEN Yazheng1 WU Junxiang1
1. Sichuan Key Laboratory of Radiation Oncology/Radiation Oncology Center, Sichuan Cancer Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu 610041, China; 2. Department of Oncology, Sichuan Science City Hospital, Mianyang 621900, China
关键词:
鼻咽癌铅门固定技术容积旋转调强剂量学
Keywords:
Keywords: nasopharyngeal carcinoma fixed-jaw technique volumetric modulated arc therapy dosimetry
分类号:
R815;R312
DOI:
DOI:10.3969/j.issn.1005-202X.2020.02.001
文献标志码:
A
摘要:
目的:比较鼻咽癌容积旋转调强(VMAT)计划设计中X轴方向不同铅门大小的剂量学差异,探讨鼻咽癌VMAT设计中最优的铅门固定大小。方法:在Eclipse 11.0计划系统中采用5种铅门固定方法分别对10例鼻咽癌患者设计放疗计划,比较5种计划得到的靶区和危及器官的剂量学参数以及机器跳数。采用SPSS 23.0软件对数据进行配对t检验分析。结果:5种固定铅门技术得到的靶区D95、Dmean和HI等剂量学参数均无明显差异(P>0.05),铅门在X2方向全关(FJ1)计划组的CI好于其他计划组(t=-2.97~-1.06, P<0.05);FJ1计划组得到的脊髓Dmax、左右侧腮腺、喉以及口咽的V30和Dmean等剂量学参数均优于其他计划组(t=-5.83~1.14, P<0.05),而对于脑干、耳蜗和颞叶等器官,5种固定铅门技术无明显差异(t=-0.99~2.99, P>0.05);FJ1计划组的机器跳数高于其他计划组(t=8.15~8.86, P<0.05)。结论:5种铅门固定技术均能满足临床要求,而FJ1计划组能够更好地降低危及器官照射剂量,但同时增加了机器跳数,增加了照射时间;而铅门在X2方向从半开到全关(FJ2)计划组相比于FJ1计划组对于器官的保护较差,但提高了治疗效率。
Abstract:
Abstract: Objective To compare dosimetric differences of X-axis directional fixed-jaw techniques in volumetric modulated arc therapy (VMAT) for nasopharyngeal carcinoma (NPC) for investigating the optimal fixed-jaw scheme. Methods In Eclipse 11.0 treatment planning system, 5 fixed-jaw techniques were used to design radiotherapy plans for 10 NPC patients. The differences in dosimetric parameters of target areas and organs-at-risk as well as monitor units were compared among 5 plans, and SPSS 23.0 software was used to perform paired sample t-test on the obtained data. Results There was no significant difference among 5 plans in the Dmean, D95 and homogeneity index of target areas (P>0.05), but the conformity index in FJ1 plan in which the jaw was fully closed in X2 direction was better than that in other fixed-jaw techniques (t=-2.97--1.06, P<0.05). The Dmax of spinal cord, the V30 and Dmean of parotid glands, larynx and oral cavity in FJ1 plan were lower than those in the others, with statistical significances (t=-5.83-1.14, P<0.05). No statistical significance was found in brainstem, cochlea and temporal lobes (t=-0.99-2.99, P>0.05). Moreover, FJ1 plan had the highest monitor units (t=8.15-8.86, P<0.05). Conclusion All the 5 fixed-jaw techniques can meet the clinical requirements, while FJ1 techniques can reduce organs-at-risk doses, but increase monitor units and delivery time. Compared with FJ1 techniques, FJ2 technique in which the jaw is changed from half-open to fully-closed in X2 direction has inferior organs-at-risk sparing, but improves treatment efficiency.

相似文献/References:

[1]陈广涛,汪 淇,刘亚强,等.TrueBeam加速器射野准直器跟随功能在鼻咽癌固定野调强放疗和容积旋转调强放疗中的应用[J].中国医学物理学杂志,2014,31(03):4865.[doi:10.3969/j.issn.1005-202X.2014.03.005]
[2]潘宇辉,陈榕钦,柏朋刚,等.鼻咽癌调强放射治疗前后腮腺体积及空间几何位置变化研究[J].中国医学物理学杂志,2014,31(05):5120.[doi:10.3969/j.issn.1005-202X.2014.05.005]
[3]张俊俊,邱小平,李奇欣,等.ArcCheck系统在鼻咽癌容积旋转调强剂量验证中的应用[J].中国医学物理学杂志,2014,31(05):5136.[doi:10.3969/j.issn.1005-202X.2014.05.009]
[4]桑 勇,陈维军,狄小云,等.多叶光栅叶片宽度对鼻咽癌剂量学的影响[J].中国医学物理学杂志,2014,31(06):5240.[doi:10.3969/j.issn.1005-202X.2014.06.004]
[5]黄利生,庄婷婷,伍方财,等.鼻咽癌调强放疗Ib区剂量分析[J].中国医学物理学杂志,2014,31(06):5265.[doi:10.3969/j.issn.1005-202X.2014.06.010]
[6]易金玲,金献测,周永强,等.鼻咽癌IMRT与VMAT治疗的计划与剂量验证比较研究[J].中国医学物理学杂志,2013,30(01):3859.[doi:10.3969/j.issn.1005-202X.2013.01.006]
[7]金献测,易金玲,周永强,等.鼻咽癌同步加量调强放射治疗新的计划质量评估指标研究[J].中国医学物理学杂志,2013,30(02):3978.[doi:10.3969/j.issn.1005-202X.2013.02.004]
[8]蒋晓芹,段宝风,艾平,等.基于图谱库的自动轮廓勾画软件(ABAS)在鼻咽癌调强放疗中的应用[J].中国医学物理学杂志,2013,30(02):3997.[doi:10.3969/j.issn.1005-202X.2013.02.008]
[9]张达光,蒋胜鹏,李智华,等.鼻咽癌调强放疗中解剖结构改变及剂量分布变化的研究[J].中国医学物理学杂志,2013,30(04):4239.[doi:10.3969/j.issn.1005-202X.2013.04.006]
[10]杨海燕,王军良,周振山,等.AAA算法和PBC算法在鼻咽癌调强放疗中剂量分布的比较[J].中国医学物理学杂志,2013,30(04):4245.[doi:10.3969/j.issn.1005-202X.2013.04.008]

备注/Memo

备注/Memo:
【收稿日期】2019-10-03 【基金项目】四川省重点研发项目(2018GZ0197);国家重点研发计划(2017YFC0113100) 【作者简介】吴凡,主管技师,研究方向:辐射物理与医学物理,E-mail:506352702@qq.com 【通信作者】吴骏翔,研究实习员,研究方向:肿瘤放射物理学,E-mail:wujx610@qq.com
更新日期/Last Update: 2020-03-03