[1]王君,随力.超声刺激对大鼠多皮层ECoG的调控[J].中国医学物理学杂志,2020,37(1):90-97.[doi:DOI:10.3969/j.issn.1005-202X.2020.01.018]
 WANG Jun,SUI Li.Regulation of electrocorticogram in multiple cortical layers of rats by ultrasound stimulation[J].Chinese Journal of Medical Physics,2020,37(1):90-97.[doi:DOI:10.3969/j.issn.1005-202X.2020.01.018]
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超声刺激对大鼠多皮层ECoG的调控()
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《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]

卷:
37
期数:
2020年第1期
页码:
90-97
栏目:
医学信号处理与医学仪器
出版日期:
2020-01-10

文章信息/Info

Title:
Regulation of electrocorticogram in multiple cortical layers of rats by ultrasound stimulation
文章编号:
1005-202X(2020)01-0090-08
作者:
王君随力
上海理工大学医疗器械与食品学院, 上海 200093
Author(s):
WANG Jun SUI Li
School of Medical Instrument and Food Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China
关键词:
超声刺激ECoG脑皮层神经调控
Keywords:
Keywords: ultrasound stimulation electrocorticogram cerebral cortex neuromodulation
分类号:
R318
DOI:
DOI:10.3969/j.issn.1005-202X.2020.01.018
文献标志码:
A
摘要:
目的:为了进一步揭示超声刺激的神经调控机制以及超声刺激引起的刺激效应范围,将超声刺激经颅施加到大鼠前额叶皮层部位,同步记录和分析前额叶、顶叶及枕叶皮层的皮层电位(Electrocorticogram, ECoG)的变化特征。方法:在大鼠麻醉状态下,利用脑立体定位仪将超声探头定位在大鼠前额叶部位的正上方,刺激时间为20 min。以功率谱密度(Power Spectral Density, PSD)、振幅及互相关系数值为指标,分析比较超声刺激前、刺激中、刺激后的ECoG总功率、平均幅值以及皮层间的互相关系数值。结果:(1)超声刺激会增加前额叶皮层ECoG的总PSD和平均幅值(P<0.05),超声刺激停止后,在较短的时间内ECoG恢复到刺激前水平;(2)在顶叶及枕叶皮层,超声刺激对总ECoG及各频段信号的PSD、平均幅值无显著性影响。但在超声刺激过程中,枕叶ECoG的部分时间段的平均幅值相对于刺激前有显著性差异,即在超声刺激的后半段时间内,超声刺激产生刺激效应范围扩散到枕叶皮层。结论:超声刺激对刺激局部的ECoG具有调控作用,且这种调控具有及时性及快速恢复的特点。超声刺激对ECoG的调控效应范围总体上来说是局限性的,对远离刺激部位的其他脑皮层ECoG的影响尚无明确关系,其效应很可能是超声刺激局部引起的后续神经网络反应。 【关键词】超声刺激;ECoG;脑皮层;神经调控
Abstract:
Abstract: Objective To further reveal the mechanisms of neuromodulation by ultrasound stimulation and the range of stimulatory effects caused by ultrasound stimulation, to apply ultrasound stimulation to the prefrontal cortex of rats for synchronously recording and analyzing the changes characteristics of electrocorticogram (ECoG) in the prefrontal, parietal and occipital cortices. Methods Under anesthesia, a stereotaxic apparatus was used to place the ultrasound transducer right above the prefrontal lobe of rats, and the stimulation duration was 20 min. Power spectral density (PSD), amplitude and interrelationship values were used as indicators to analyze and compare the total power and mean amplitude of ECoG as well as interrelationship values among cortices of pre-, mid- and post-ultrasonic stimulations. Results (1) Ultrasound stimulation increased the total PSD and mean amplitude of the ECoG of the prefrontal cortex (P<0.05). After the ultrasound stimulation stopped, the ECoG returned to the pre-stimulation level in a short time. (2) In the parietal and occipital cortices, ultrasound stimulation had no significant effect on the PSD and mean amplitude of ECoG and each frequency band. However, during the ultrasound stimulation, the average amplitude of the partial periods in the occipital cortex was obviously different from that before stimulation, which indicated that during the second half of the ultrasound stimulation, the range of the stimulatory effect caused by ultrasound stimulation was diffused to the occipital cortex. Conclusion Ultrasound stimulation can regulate the ECoG of local stimulation region, and the neuromodulation has the characteristics of promptness and rapid recovery. In general, the regulation effect of ultrasound stimulation on ECoG is limited. The effect of ultrasound stimulation on the ECoG of other cortical layers away from the stimulation sites remains unclear, and the effect is probably the subsequent neural network response caused by ultrasound stimulation.

备注/Memo

备注/Memo:
【收稿日期】2019-06-09 【基金项目】国家自然科学基金(11179015);上海理工大学科技发展项目(16KJFZ107, 2017KJFZ160) 【作者简介】王君,硕士研究生,研究方向:生物医学工程,E-mail: wj_150917@163.com 【通信作者】随力,教授,研究方向:神经工程,E-mail: lsui@usst.edu.cn
更新日期/Last Update: 2020-01-14