[1]徐丰源,李德超,孙良庆,等. 电参数对钛微弧氧化膜层理化性能及细胞相容性的影响[J].中国医学物理学杂志,2018,35(11):1334-1338.[doi:DOI:10.3969/j.issn.1005-202X.2018.11.018]
　XU Fengyuan,LI Dechao,SUN Liangqing,et al. Effects of electrical parameters on physical and chemical properties and cellular compatibility of micro-arc oxidation coat on titanium[J].Chinese Journal of Medical Physics,2018,35(11):1334-1338.[doi:DOI:10.3969/j.issn.1005-202X.2018.11.018]
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 电参数对钛微弧氧化膜层理化性能及细胞相容性的影响()
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《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]

卷:
35卷
期数:
2018年第11期
页码:
1334-1338
栏目:
医学生物物理
出版日期:
2018-11-18

文章信息/Info

Title:
 Effects of electrical parameters on physical and chemical properties and cellular compatibility of micro-arc oxidation coat on titanium
文章编号:
005-202X（2018）11-1334-05
作者:
 徐丰源; 李德超; 孙良庆; 李慕勤
佳木斯大学黑龙江省高校生物医学材料重点实验室， 黑龙江 佳木斯 154007
Author(s):
 XU Fengyuan;  LI Dechao;  SUN Liangqing;  LI Muqin
 Key Biomedical Materials Laboratory of Colleges and Universities in Heilongjiang Province, Jiamusi University, Jiamusi 154007, China
关键词:
钛; 微弧氧化; 脉冲宽度; 脉冲频率; 细胞相容性
Keywords:
 ; Keywords: titanium;  micro-arc oxidation;  pulse width;  pulse frequency;  cellular compatibility
分类号:
R318；TB34
DOI:
DOI:10.3969/j.issn.1005-202X.2018.11.018
文献标志码:
A
摘要:
 目的：研究纯钛微弧氧化电参数（脉冲宽度及脉冲频率）的改变对膜层表面形貌、理化性能及成骨细胞生物行为的影响。 方法：对喷砂酸蚀钛片进行微弧氧化处理，通过脉宽及频率的变化，研究其对膜层的表面形貌、摩擦性能、耐腐蚀性等影响，分析得出不同表面形貌所对应的参数条件（脉冲频率400 Hz、脉冲宽度60 μs微弧氧化组为A组，脉冲频率500 Hz、脉冲宽度60 μs微弧氧化组为B组，脉冲频率500 Hz、脉冲宽度75 μs的微弧氧化组为C组），进一步比较在该参数下的微弧氧化膜的耐腐蚀性及成骨细胞在其表面的粘附、增殖情况及细胞形态。 结果：电镜下3组试件表面均形成粗糙多孔的膜层，且A组纯钛微弧氧化膜表面粗糙度最高；C组所制备的微弧氧化膜层耐腐蚀性能及耐磨性优于A、B两组。细胞粘附及增殖实验A、B、C各组之间差异有统计学意义（P<0.05），实验表明A组表面成骨细胞粘附及增殖均优于B、C两组。 结论：脉冲宽度及频率变化对微弧氧化膜层表面生物活性及理化性能均有影响，当脉冲频率400 Hz、脉冲宽度60 μs时，膜层表面的细胞生长最佳。
Abstract:
 Abstract: Objective To study the effects of pure titanium micro-arc oxidation parameters (pulse width and pulse frequency) on film surface morphology, physical and chemical properties and biocompatibility of osteoblasts. Methods The sandblasted and acid-etched titanium plate was treated with micro-arc oxidation. The surface morphology, friction property and corrosion resistance of the film layer were studied by changing the pulse width and frequency of micro-arc oxidation, thus obtaining the parameters corresponding to different surface topography. The pulse frequency and width of micro-arc oxidation were 400 Hz and 60 μs in group A, 500 Hz and 60 μs in group B, and 500 Hz and 75 μs in group C. The corrosion resistance of the micro-arc oxidation film and the adhesion, proliferation and cell morphology of the osteoblasts on the surface were further analyzed. Results Under electron microscope, rough and poriferous film layers were observed on the surface of 3 groups of specimens, and the surface roughness of pure titanium micro-arc oxidation film in group A was the highest. The corrosion resistance and wear resistance of the micro-arc oxidation film in group C were better than those of the micro-arc oxidation film in group A and B. The experiment of cell adhesion and proliferation showed that the differences among groups A, B and C were statistically significant (P<0.05), and the adhesion and proliferation of osteoblasts in group A were better than those of osteoblasts in group B and C. Conclusion Pulse width and frequency have affects on the surface biological activity and the physical and chemical properties of micro-arc oxidation film layer. With the pulse frequency of 400 Hz and the pulse width of 60 μs, the cells on the surface of the film layer grow best.

相似文献/References:

[1]梁鹏晨,李路易,常庆,等.微弧氧化技术在骨科钛植入体生物功能改性中的应用进展[J].中国医学物理学杂志,2019,36(11):1335.[doi:DOI:10.3969/j.issn.1005-202X.2019.11.017]
　LIANG Pengchen,LI Luyi,CHANG Qing,et al.Progress on micro-arc oxidation technology in biological functional modification of orthopaedic titanium implants[J].Chinese Journal of Medical Physics,2019,36(11):1335.[doi:DOI:10.3969/j.issn.1005-202X.2019.11.017]

备注/Memo

备注/Memo:
 【收稿日期】2018-05-11
【基金项目】国家自然科学基金（31370979）
【作者简介】徐丰源，硕士研究生，研究方向：口腔种植学，E-mail：934061241@qq.com
【通信作者】李慕勤，教授，博士生导师，主要研究方向：生物医学材料表面改性，E-mail: jmsdxlimuqin@163.com；李德超，教授，研究生导师，主要从事口腔颌面外科与口腔种植学工作，E-mail: Dechaoli2004@163.com
更新日期/Last Update: 2018-11-22