[1]张国前,张书旭,王锐濠,等. Auto-planning在脑胶质瘤非共面容积调强放疗计划中的应用[J].中国医学物理学杂志,2018,35(5):514-518.[doi:DOI:10.3969/j.issn.1005-202X.2018.05.004]
　ZHANG Guoqian,ZHANG Shuxu,WANG Ruihao,et al. Application research on Auto-planning in non-coplanar VMAT plan for brain gliomas[J].Chinese Journal of Medical Physics,2018,35(5):514-518.[doi:DOI:10.3969/j.issn.1005-202X.2018.05.004]
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 Auto-planning在脑胶质瘤非共面容积调强放疗计划中的应用()
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《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]

卷:
35卷
期数:
2018年第5期
页码:
514-518
栏目:
医学放射物理
出版日期:
2018-05-22

文章信息/Info

Title:
 Application research on Auto-planning in non-coplanar VMAT plan for brain gliomas
文章编号:
1005-202X（2018）05-0514-05
作者:
 张国前1; 张书旭1; 王锐濠1 ; 雷怀宇1; 李万桢2; 廖博玉2
 1.广州医科大学附属肿瘤医院放疗中心， 广东 广州 510095； 2.广州医科大学研究生学院， 广东 广州 510182
Author(s):
 ZHANG Guoqian1;  ZHANG Shuxu1;  WANG Ruihao1;  LEI Huaiyu1;  LI Wanzhen2;  LIAO Boyu2
 1. Department of Radiotherapy, Cancer Center of Guangzhou Medical University, Guangzhou 510095, China; 2. Graduate School, Guangzhou Medical University, Guangzhou 510182, China
关键词:
 ; 胶质瘤; Auto-planning; 非共面容积调强放疗; 手动容积调强放疗计划
Keywords:
 ; gliomas;  Auto-planning;  non-coplanar volumetric modulated arc therapy;  manual volumetric modulated arc therapy plan
分类号:
R737.33；R730.55
DOI:
DOI:10.3969/j.issn.1005-202X.2018.05.004
文献标志码:
A
摘要:
 目的：通过比较基于Auto-planning的胶质瘤非共面自动容积旋转调强放疗（AP-VMAT）计划与常规手动非共面VMAT（M-VMAT）计划在靶区和危及器官（OAR）的剂量学差异，探讨自动优化在非共面胶质瘤VMAT计划中应用的可行性。 方法：选取2016-02-15～2016-12-18在广州医科大学附属肿瘤医院放疗科接受治疗的8例胶质瘤患者，进行CT模拟定位及靶区和OAR的勾画，采用Pinnacle 9.10治疗计划系统基于同一CT图像分别设计M-VMAT计划和AP-VMAT计划，比较手动和自动两种调强计划的靶区覆盖、分析靶区均匀性指数、适形度指数及OAR受照剂量差异。 结果：两种计划靶区覆盖率、平均剂量（Dmean）、均匀性指数差异均无统计学意义（P>0.05）。AP-VMAT 计划的适形度指数明显优于M-VMAT计划，差异有统计学意义［（0.890±0.046） vs （0.750±0.046）, P<0.001］；两种计划OAR中脑干最大剂量、D5，同侧眼球、晶体、视神经最大剂量、Dmean差异均无统计学意义（P>0.05），而AP-VMAT 计划中脑干Dmean及视交叉、对侧眼球、晶体、视神经和正常脑组织的剂量评价参数均优于M-VMAT计划，差异有统计学意义（P<0.05）。 结论：相比M-VMAT计划，基于Auto-planning的自动优化方式能够简化调强计划设计过程，并一定程度上改善靶区的剂量分布，降低OAR的受照剂量。
Abstract:
 Objective To discuss the feasibility of Auto-planning based non-coplanar volumetric modulated arc therapy (AP-VMAT) plan for glioma by comparing AP-VMAT plan and conventional manual volumetric modulated arc therapy (M-VMAT) plan in terms of the dosimetric differences of planning target volume (PTV) and organs-at-risk (OAR). Methods From February 15 to December 18, 2016, 8 glioma patients receiving treatment in Cancer Center of Guangzhou Medical University were selected for CT-simulation based localization and segmentation of PTV and OAR. Non-coplanar M-VMAT plan and AP-VMAT plan were designed for the same set of CT images with the use of Pinnacle 9.10 treatment planning system. The target coverage (D95), homogeneity index and conformity index of PTV, and OAR dose were compared between M-VMAT plan and AP-VMAT plan. Results The comparison between AP-VMAT plan and M-VMAT plan didn’t showed any statistical differences in D95, mean dose (Dmean) and homogeneity index (P>0.05). The conformity index in AP-VMAT plan was better than that in M-VMAT plan ［(0.890±0.046) vs (0.750±0.046), P<0.001］. No significant differences between the two plans was found in the maximum dose and D5 of brainstem, the maximum dose and Dmean of ipsilateral eyeball, lens and optic nerve (P>0.05). However, the Dmean of brainstem and the dosimetric parameters of contralateral eyeball, lens, optic nerve and normal tissues were less in AP-VMAT plan as compared with M-VMAT plan (P<0.05). Conclusion Compared with M-VMAT plan, non-coplanar AP-VMAT plan simplify the design process and improve the target conformity and OAR sparing.

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备注/Memo

备注/Memo:
 【收稿日期】2017-11-08
【基金项目】广东省科技计划项目（2016A020215173）
【作者简介】张国前，硕士，主管技师，研究方向：放射物理，E-mail: zgqcc@126.com
【通信作者】张书旭，博士，主任技师，博士生导师，E-mail：gthzsx@163.com
更新日期/Last Update: 2018-05-22