[1]王佳琦,张艺宝,杨道科.肿瘤电场治疗在胶质母细胞瘤中的研究进展[J].中国医学物理学杂志,2026,43(7):965-969.[doi:DOI:10.3969/j.issn.1005-202X.2026.07.018]
　WANG Jiaqi? ? ZHANG Yibao? YANG Daoke?/html>.Advances in tumor-treating fields for glioblastoma[J].Chinese Journal of Medical Physics,2026,43(7):965-969.[doi:DOI:10.3969/j.issn.1005-202X.2026.07.018]
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肿瘤电场治疗在胶质母细胞瘤中的研究进展()

《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]

卷:
43卷
期数:
2026年第7期
页码:
965-969
栏目:
医学生物物理
出版日期:
2026-07-22

文章信息/Info

Title:
Advances in tumor-treating fields for glioblastoma
文章编号:
1005-202X（2026）07-0965-05
作者:
王佳琦1; 2; 张艺宝3; 杨道科2
1.郑州大学基础医学院， 河南 郑州 450001； 2.郑州大学第一附属医院放疗科， 河南 郑州 450003； 3.北京大学肿瘤医院暨北京市肿瘤防治研究所放疗科/恶性肿瘤发病机制及转化研究教育部重点实验室， 北京 100142
Author(s):
WANG Jiaqi? ? ZHANG Yibao? YANG Daoke?/html>
1. School of Basic Medical Sciences, Zhengzhou University, Zhengzhou 450001, China 2. Department of Radiation Oncology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450003, China 3. Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education, Beijing)/Department of Radiation Oncology, Peking University Cancer Hospital and Institute, Beijing 100142, China
关键词:
胶质母细胞瘤; 肿瘤电场治疗; 安全性; 联合治疗; 综述
Keywords:
glioblastoma tumor treating fields safety combination therapy review
分类号:
R739.41
DOI:
DOI:10.3969/j.issn.1005-202X.2026.07.018
文献标志码:
A
摘要:
胶质母细胞瘤（GBM）是成人中枢神经系统最为高发的恶性肿瘤之一，患者即便完成手术联合放化疗的标准治疗后复发率仍处于较高水平。肿瘤电场治疗（TTFields）是近年来用于GBM临床干预的非侵入性物理疗法，核心原理是向区域施加低强度、中频交变电场，通过干扰纺锤体微管组装等途径阻滞肿瘤细胞的有丝分裂。TTFields作为单一疗法，其疗效提升有限。因此，当前的研究重点逐步转向TTFields联合其他治疗模式。本文通过综述TTFields发挥抗肿瘤作用的核心分子机制，讨论其与化疗、放疗、免疫治疗等不同治疗方案的联合应用，分析协同增效的生物学基础与临床进展，并在此基础上明确TTFields在GBM综合治疗体系中的地位，以期为后续临床方案的优化提供参考。
Abstract:
Abstract: Glioblastoma (GBM) is one of the most common malignant tumors of the central nervous system in adults. Even after standard treatment combining surgery, radiotherapy and chemotherapy, its recurrence rate remains relatively high. Tumor treating fields (TTFields) is a non-invasive physical therapeutic modality newly approved for clinical intervention in GBM, and its core mechanism involves applying low-intensity, intermediate-frequency alternating electric fields to specific regions, thereby inhibiting tumor cell mitosis by disrupting spindle microtubule assembly and other pathways. As monotherapy, TTFields shows limited improvements in efficacy. Therefore, the focus of current research has gradually shifted towards combining TTFields with other treatment modalities. This review summarizes the core molecular mechanisms through which TTFields exerts anti-tumor effects, discusses its combined applications with chemotherapy, radiotherapy, immunotherapy, and other treatment strategies, and analyzes the biological basis and clinical advances of their synergistic effects. Furthermore, this study clarifies the role of TTFields in the comprehensive treatment framework for GBM, aiming to provide a reference for optimizing future clinical protocols.

相似文献/References:

[1]杨丽姝,刘丽珠,韩波.肿瘤治疗电场的微观机制及临床应用进展[J].中国医学物理学杂志,2021,38(7):883.[doi:DOI:10.3969/j.issn.1005-202X.2021.07.018]
　YANG Lishu,LIU Lizhu,HAN Bo.Micromechanism of tumor treating fields and advances in its clinical application[J].Chinese Journal of Medical Physics,2021,38(7):883.[doi:DOI:10.3969/j.issn.1005-202X.2021.07.018]
[2]胡小洋,韩磊,汪洋,等.TTF电极阵列及头皮保护技术对放疗剂量分布影响的初步研究[J].中国医学物理学杂志,2022,39(2):169.[doi:DOI:10.3969/j.issn.1005-202X.2022.02.007]
　HU Xiaoyang,HAN Lei,WANG Yang,et al.Preliminary study on the effects of electrodes array for tumor treating fields and scalp sparing technology on the dose distribution in radiotherapy[J].Chinese Journal of Medical Physics,2022,39(7):169.[doi:DOI:10.3969/j.issn.1005-202X.2022.02.007]
[3]许彦龙,李国强,余跃,等.肿瘤电场治疗在胶质母细胞瘤治疗中的应用进展[J].中国医学物理学杂志,2021,38(5):647.[doi:DOI:10.3969/j.issn.1005-202X.2021.05.023]
　XU Yanlong,,et al.Advances in application of tumor treating fields in glioblastoma[J].Chinese Journal of Medical Physics,2021,38(7):647.[doi:DOI:10.3969/j.issn.1005-202X.2021.05.023]

备注/Memo

备注/Memo:
【收稿日期】2026-04-02 【基金项目】中央高校基本科研业务费/北京大学临床医学+X青年专项（PKU2025PKULCXQ014） 【作者简介】王佳琦，硕士研究生，研究方向：放射肿瘤学，E-mail: cwgamma@163.com 【通信作者】杨道科，英国皇家医学会院士，二级教授，中原名医，主任医师，硕士生导师，研究方向：放射肿瘤学，E-mail: 15903650068@163.com
更新日期/Last Update: 2026-07-23