[1]方雅岚,邓官华,唐冉,等.一种基于Halcyon加速器的共面容积旋转调强海马保护全脑放疗计划[J].中国医学物理学杂志,2026,43(7):841-846.[doi:DOI:10.3969/j.issn.1005-202X.2026.07.001]
　FANG Yalan,DENG Guanhua,TANG Ran,et al.Coplanar volumetric modulated arc therapy plan for hippocampal avoidance whole?rain radiotherapy implemented on a Halcyon linear accelerator[J].Chinese Journal of Medical Physics,2026,43(7):841-846.[doi:DOI:10.3969/j.issn.1005-202X.2026.07.001]
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一种基于Halcyon加速器的共面容积旋转调强海马保护全脑放疗计划()

《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]

卷:
43卷
期数:
2026年第7期
页码:
841-846
栏目:
医学放射物理
出版日期:
2026-07-22

文章信息/Info

Title:
Coplanar volumetric modulated arc therapy plan for hippocampal avoidance whole?rain radiotherapy implemented on a Halcyon linear accelerator
文章编号:
1005-202X（2026）07-0841-06
作者:
方雅岚1; 邓官华2; 唐冉3; 蓝茂英4; 罗日顺5
1.中山大学肿瘤防治中心门诊部， 广东 广州 510060；2.南方医科大学附属广东省人民医院（广东省医学科学院）放疗科， 广东 广州 510080；3.广州医科大学附属惠州医院放疗科， 广东 惠州 516000；4.广州医科大学附属第一医院放疗科， 广东 广州 510163；5.广东三九脑科医院肿瘤综合诊疗中心， 广东 广州 510510
Author(s):
FANG Yalan1;  DENG Guanhua2;  TANG Ran3;  LAN Maoying4;  LUO Rishun5
1. Outpatient Department, Sun Yat-sen University Cancer Center, Guangzhou 510060, China 2. Department of Radiation Oncology, Guangdong Provincial Peoples Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou 510080, China 3. Department of Radiation Oncology, the Affiliated Huizhou Hospital of Guangzhou Medical University, Huizhou 516000, China 4. Department of Radiation Oncology, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510163, China 5. Department of Oncology, Guangdong Sanjiu Brain Hospital, Guangzhou 510510, China
关键词:
Halcyon加速器; 海马保护; 全脑放疗; 容积旋转调强
Keywords:
Halcyon accelerator hippocampus avoidance whole-brain radiotherapy volumetric modulated arc therapy
分类号:
R318；R811.1
DOI:
DOI:10.3969/j.issn.1005-202X.2026.07.001
文献标志码:
A
摘要:
目的：比较瓦里安Halcyon、TrueBeam和联影uRT-506c加速器在海马保护全脑放疗中的剂量学差异。方法：选取15例已接受过海马保护全脑放疗的患者进行回顾性分析。分别采用Halcyon、TrueBeam和uRT-506c加速器模型设计共面双弧容积旋转调强放疗（VMAT）计划，准直器角度分别为23°和293°。根据海马位置，将全脑靶区拆分成3个子结构（zPTV_up、zPTV_mid和zPTV_down），给予不同权重参数优化。记录并分析3组计划的靶区（PTV）剂量学参数、危及器官受量和机器跳数的差异。结果：所有患者的VMAT计划均能满足临床治疗标准。Halcyon计划的PTV D2%、V30 Gy和HI，海马D100%、Dmean和Dmax，晶体和视神经的Dmax，均优于TrueBeam和uRT-506c计划，差异有统计学意义（P<0.05）。结论：Halcyon直线加速器在保护海马的全脑放疗中具有更优的剂量分布和可靠的计划计算结果，环形机架既保证了高效的执行效率，又展示出了精准放疗的优势，具有不错的临床应用前景。
Abstract:
Objective To compare the dosimetric differences among Varian Halcyon, TrueBeam, and United Imaging uRT-506c linear accelerator in hippocampal avoidance whole?rain radiotherapy. Methods A retrospective analysis was conducted on 15 patients who had previously received hippocampal avoidance whole-brain volumetric modulated arc therapy (VMAT). Dual-arc coplanar VMAT plans were created using the Halcyon, TrueBeam, and uRT-506c accelerator models, with collimator angles of 23° and 293°, respectively. Based on the position of the hippocampus, the whole-brain target volume was divided into 3 substructures (zPTV_up, zPTV_mid, and zPTV_down), each optimized using different weight factors. The dosimetric parameters of the planning target volume, organ-at-risk doses, and monitor unit in the 3 groups were recorded and analyzed. Results VMAT plans for all patients satisfied clinical treatment criteria. Halcyon plans were superior to True Beam and uRT-506c plans in the D2%, V30 Gy, and HI of planning target volume, the D100%, Dmean, and Dmax of the hippocampus, as well as the Dmax of the lens and optic nerves, with statistically significant differences (P<0.05). Conclusion For hippocampus avoidance whole-brain radiotherapy, the Halcyon linear accelerator delivers superior dose distribution and robust plan calculation results, and its ring gantry ensures efficient treatment delivery while highlighting the strengths of precise radiotherapy, showing great potential for clinical practice.

相似文献/References:

[1]王为,蒋马伟,沈奕晨,等. 螺旋断层放射治疗在儿童神经母细胞瘤全颅骨放疗中保护海马的计划设计[J].中国医学物理学杂志,2017,34(10):977.[doi:DOI:10.3969/j.issn.1005-202X.2017.10.002]
　[J].Chinese Journal of Medical Physics,2017,34(7):977.[doi:DOI:10.3969/j.issn.1005-202X.2017.10.002]

备注/Memo

备注/Memo:
【收稿日期】2026-01-25 【基金项目】广东省医学科研基金（A2023250） 【作者简介】方雅岚，主治医师，研究方向：头颈部肿瘤的综合治疗，E-mail: fangyl@sysucc.org.cn 【通信作者】罗日顺，主管技师，研究方向：放射物理质控，E-mail: 599046206@qq.com
更新日期/Last Update: 2026-07-22