[1]孙滋唯,孙岩洲,李笑宇,等.血流动力学指数构建及评估血管老化研究[J].中国医学物理学杂志,2026,43(8):1093-1099.[doi:DOI:10.3969/j.issn.1005-202X.2026.08.014]
　SUN Ziwei,SUN Yanzhou,LI Xiaoyu,et al.Construction of hemodynamic vascular index and its application for assessing vascular aging[J].Chinese Journal of Medical Physics,2026,43(8):1093-1099.[doi:DOI:10.3969/j.issn.1005-202X.2026.08.014]
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血流动力学指数构建及评估血管老化研究()

《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]

卷:
43卷
期数:
2026年第8期
页码:
1093-1099
栏目:
医学信号处理与医学仪器
出版日期:
2026-09-15

文章信息/Info

Title:
Construction of hemodynamic vascular index and its application for assessing vascular aging
文章编号:
1005-202X（2026）08-1093-07
作者:
孙滋唯1; 孙岩洲1; 2; 李笑宇1; 杨磊1; 乔钲1
1.河南理工大学电气工程与自动化学院， 河南 焦作 454003；2.河南省煤矿装备智能检测与控制重点实验室， 河南 焦作 454003
Author(s):
SUN Ziwei1;  SUN Yanzhou1;  2;  LI Xiaoyu1;  YANG Lei1;  QIAO Zheng1
1. School of Electrical Engineering and Automation, Henan Polytechnic University, Jiaozuo 454003, China 2. Henan Key Laboratory of Intelligent Detection and Control for Coal Mine Equipment, Jiaozuo 454003, China
关键词:
桡动脉脉搏波; 反射比; 时域分析; 血流动力学指数; 血管功能评估; 血管老化
Keywords:
Keywords: radial artery pulse wave reflection ratio time-domain analysis hemodynamic vascular index vascular function assessment vascular aging
分类号:
R318
DOI:
DOI:10.3969/j.issn.1005-202X.2026.08.014
文献标志码:
A
摘要:
目的：为提升基于桡动脉脉搏波的无创血管功能评估效能，构建融合多时域血流动力学参数的综合指标-血流动力学指数（HVI），用于表征与年龄相关的血管功能变化。方法：在恒定接触压力下采集青年、中年与老年3组受试者的桡动脉脉搏波信号，通过三角形血流波形分解并计算反射波幅值比（RM）、反射指数（RI）与重搏波比（Rd），并基于主成分分析（PCA）构建综合反射指数HVI。采用ROC曲线评估各指标的判别效能，并通过5折交叉验证检验HVI的泛化能力。结果：RM与RI随年龄增加而升高，Rd在老年组显著增大，反映血管顺应性下降和反射增强。HVI在3组间差异显著，青年vs.老年组的AUC为0.978，高于单一指标；在青年vs.中年及中年vs.老年比较中亦保持较高区分性能。交叉验证结果（平均AUC=0.914）表明HVI具有良好稳定性与泛化能力。结论：HVI能有效整合多项反射信息，比传统单参数更全面反映年龄相关的血管功能变化，具有作为血管老化量化指标的潜力。其应用定位在于描述血管功能状态，而非年龄分类工具，可为未来的血管老化监测与风险分层研究提供方法学基础。
Abstract:
Abstract: Objective To develop a composite hemodynamic index termed hemodynamic vascular index (HVI) that integrates multiple time-domain parameters to characterize age-related vascular functional changes, thereby enhancing the performance of noninvasive vascular function assessment based on radial artery pulse waves. Methods Radial artery pulse wave signals from young, middle-aged, and elderly subjects were collected under constant contact pressure. Reflection magnitude (RM), reflection index (RI), and re-dicrotic ratio (Rd) were obtained through triangular flow waveform decomposition, and HVI was developed using principal component analysis. Receiver operating characteristic (ROC) curve analysis was performed to evaluate the discriminative performance of each parameter, and 5-fold cross-validation was used to examine the generalization ability of HVI. Results RM and RI increased progressively with age, while Rd was markedly elevated in the elderly group, reflecting reduced arterial compliance and enhanced wave reflection. HVI differed significantly among the 3 groups. HVI achieved an AUC of 0.978 in distinguishing young from elderly subjects, which was higher than any single parameter, and also maintained strong discriminative performance in the young vs middle-aged and middle-aged vs elderly comparisons. Cross-validation yielded a mean AUC of 0.914, demonstrating favorable stability and generalizability of HVI. Conclusion HVI can effectively integrate multiple reflection-related features and provides a more comprehensive representation of age-related vascular functional alterations than traditional single parameters, with the potential as a quantitative indicator for vascular aging. Positioned as an indicator characterizing vascular functional status rather than an age-classification tool, HVI offers methodological support for future studies on vascular aging monitoring and cardiovascular risk stratification.

备注/Memo

备注/Memo:
【收稿日期】2026-05-10 【基金项目】河南省自然科学基金（252300421329） 【作者简介】孙滋唯，硕士研究生，研究方向：电工电能新技术及生物医电，E-mail: 2455227841@qq.com 【通信作者】孙岩洲，博士，教授，研究方向：气体放电、高电压工程及供电技术，E-mail: sunyz@hpu.edu.cn
更新日期/Last Update: 2026-09-15