[1]王远远.质子与光子治疗系统机载CBCT成像质量与剂量对比研究[J].中国医学物理学杂志,2025,42(7):841-846.[doi:DOI:10.3969/j.issn.1005-202X.2025.07.001]
　WANG Yuanyuan.Comparative study of the imaging quality and dose in on-board CBCT for proton versus photon radiotherapy systems[J].Chinese Journal of Medical Physics,2025,42(7):841-846.[doi:DOI:10.3969/j.issn.1005-202X.2025.07.001]
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质子与光子治疗系统机载CBCT成像质量与剂量对比研究()

《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]

卷:
42
期数:
2025年第7期
页码:
841-846
栏目:
医学放射物理
出版日期:
2025-07-25

文章信息/Info

Title:
Comparative study of the imaging quality and dose in on-board CBCT for proton versus photon radiotherapy systems
文章编号:
1005-202X（2025）07-0841-06
作者:
王远远
1.中国科学技术大学附属第一医院离子医学中心（合肥离子医学中心），安徽 合肥 230088；2.中国科学院合肥物质科学研究院，安徽 合肥 230031
Author(s):
WANG Yuanyuan
1. Hefei Ion Medical Center, the First Affiliated Hospital of University of Science and Technology of China, Hefei 230088, China; 2. Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei 230031, China
关键词:
图像引导; 锥形束CT; 质子治疗系统; 影像性能; 成像剂量
Keywords:
image-guided;  cone-beam computed tomography;  proton therapy system;  imaging performance;  imaging dose
分类号:
R318；R811.1
DOI:
DOI:10.3969/j.issn.1005-202X.2025.07.001
文献标志码:
A
摘要:
目的：对比分析瓦里安ProBeam质子治疗系统与Vitalbeam直线加速器所配机载千伏级锥形束CT（kV-CBCT）的影像性能及成像剂量差异，探究差异成因并提出质子治疗系统机载CBCT的改进方向。方法：采用CatPhan504模体及CT电离室剂量仪，在标准头部和标准盆腔模式下进行CBCT扫描，系统评估两种系统的CT值准确性、图像均匀性、空间几何形变、空间分辨率、低对比度、噪声及加权CT剂量指数（CTDIw）。结果：瓦里安Vitalbeam直线加速器机载CBCT在两种扫描模式下的 CT 值准确性和图像均匀性方面均优于 ProBeam 质子治疗系统系统机载 CBCT。空间几何形变均在±0.3 mm以内，且二者无显著差异。空间分辨率、低对比度和噪声方面，光子系统机载CBCT均表现出优于质子系统的结果。光子系统在成像剂量方面要大于质子系统，两种扫描模式下的 CTDIw 分别为 3.59 mGy vs. 1.38 mGy（头部模式）和 40.03 mGy vs. 9.96 mGy（盆腔模式）。结论：瓦里安ProBeam质子治疗系统机载CBCT在影像性能方面整体劣于Vitalbeam直线加速器机载CBCT，而在成像剂量方面光子系统机载CBCT相对较高。差异来源主要是由于质子治疗系统采用更大的SID设计，导致探测到的散射光子数量减少，成像性能相比光子机载CBCT降低，可以考虑通过改变CBCT系统结构设计和硬件的提升及算法的优化来进一步改善质子治疗系统机载CBCT的影像质量。
Abstract:
Abstract: Objective To comparatively analyze the imaging performance and dose characteristics of on-board kilovolt cone beam computed tomography (kV-CBCT) integrated with the Varian ProBeam proton therapy system and Vitalbeam linac, investigate the underlying causes of the discrepancies, and propose optimization strategies for on-board CBCT for proton therapy system. Methods CBCT scans were performed in standard head and pelvic protocols using a CatPhan504 phantom and CT ionization chamber dosimeter to systematically assess the accuracy of CT values, image homogeneity, spatial geometric deformation, spatial resolution, low-contrast, noise and weighted CT dose index (CTDIw) of both systems. Results The on-board CBCT for Vitalbeam linac demonstrated better performance in terms of CT value accuracy and image homogeneity in both scanning protocols than the on-board CBCT for ProBeam proton therapy system. Spatial geometric deformations remained within ±0.3 mm, and there was no significant difference between the two systems. Furthermore, the on-board CBCT for photon therapy system was advantageous in terms of spatial resolution, low contrast, and noise when compared to the proton therapy system. The imaging dose was higher for photon therapy system than proton therapy system, with CTDIw of 3.59 vs 1.38 mGy in head protocol, and 40.03 vs 9.96 mGy in pelvic protocol, respectively. Conclusion The on-board CBCT for the Varian ProBeam proton therapy system is inferior to Vitalbeam on-board CBCT in imaging performance, while having relatively lower imaging doses in comparison. The source of the discrepancies is mainly from the larger SID design of the proton therapy system, which leads to a reduction in the number of detected scattered photons and a reduced imaging performance than the on-board CBCT for photon therapy system. Potential strategies to enhance the imaging quality of proton therapy system on-board CBCT may involve structural redesign of the CBCT system, hardware upgrade, and algorithm optimization.

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备注/Memo

备注/Memo:
【收稿日期】2025-02-18【基金项目】国家自然科学基金（82202945）；合肥市自然科学基金（202334）；合肥综合性国家科学中心入库项目【作者简介】王远远，硕士，工程师，研究方向：医学物理，E-mail: wangyuanyuan@himc.org.cn
更新日期/Last Update: 2025-07-25