[1]乔凌,唐世化,姚家好.低温等离子手术治疗儿童OSAHS的疗效及其对炎症反应、免疫功能、疼痛和睡眠情况等的影响[J].中国医学物理学杂志,2025,42(7):956-961.[doi:DOI:10.3969/j.issn.1005-202X.2025.07.017]
　QIAO Ling,TANG Shihua,YAO Jiahao.Efficacy of low-temperature plasma surgery for the treatment of OSAHS in children and its effects on inflammatory response, immune function, pain and sleep quality[J].Chinese Journal of Medical Physics,2025,42(7):956-961.[doi:DOI:10.3969/j.issn.1005-202X.2025.07.017]
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低温等离子手术治疗儿童OSAHS的疗效及其对炎症反应、免疫功能、疼痛和睡眠情况等的影响()

《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]

卷:
42
期数:
2025年第7期
页码:
956-961
栏目:
医学生物物理
出版日期:
2025-07-25

文章信息/Info

Title:
Efficacy of low-temperature plasma surgery for the treatment of OSAHS in children and its effects on inflammatory response, immune function, pain and sleep quality
文章编号:
1005-202X（2025）07-0956-06
作者:
乔凌; 唐世化; 姚家好
安徽省淮南新华医疗集团新华医院耳鼻喉科，安徽 淮南 232000
Author(s):
QIAO Ling;  TANG Shihua;  YAO Jiahao
Department of Otorhinolaryngology, Head and Neck Surgery, Xinhua Hospital of Huainan Xinhua Medical Group, Huainan 232000,China
关键词:
睡眠呼吸暂停低通气综合征; 儿童; 低温等离子手术; 炎症反应; 免疫功能; 疼痛; 睡眠
Keywords:
obstructive sleep apnea-hypopnea syndrome;  children;  low-temperature plasma surgery;  inflammatory response; immune function;  pain;  sleep
分类号:
R318；R766
DOI:
DOI:10.3969/j.issn.1005-202X.2025.07.017
文献标志码:
A
摘要:
目的：分析睡眠呼吸暂停低通气综合征（OSAHS）患儿应用低温等离子手术治疗的疗效及其对炎症反应、免疫功能、疼痛和睡眠情况等指标的影响，为OSAHS的合理治疗提供依据。方法：前瞻性选取OSAHS患儿92例作为研究对象，病例选取时间为2021年1月至2023年12月，随机将患儿分为对照组、试验组，各46例。对照组患儿给予常规扁桃体及腺样体切除术，观察组患儿给予低温等离子扁桃体及腺样体消融术，术后均进行6个月的随访，随访期间均无失访病例。比较两组术后6个月的疗效，手术相关指标，术后1、2、3 d的疼痛情况，术前和术后6个月的睡眠情况、炎症反应、免疫功能及随访6个月内的并发症发生情况。结果：较对照组，试验组术后6个月的总有效率更高（93.48% vs 78.26%，P<0.05）。较对照组，试验组术中出血量更少，手术及住院时间更短（P<0.05）。术后1、2、3 d两组视觉模拟评分法评分逐渐降低，且较对照组，试验组更低（P<0.05）。两组呼吸暂停低通气指数、呼吸紊乱指数在术后 6个月与术前比较降低，试验组更低（P<0.05）；两组最低血氧饱和度升高，试验组更高（P<0.05）。两组血清降钙素原、白细胞介素-1β、白细胞介素-6、超敏C反应蛋白、肿瘤坏死因子-α 及全血 CD8+水平在术后 3 d 与术前比较降低，试验组更低（P<0.05）；两组全血 CD3+、CD4+、CD4+/CD8+升高，试验组更高（P<0.05）。较对照组，试验组随访 6 个月内的并发症总发生率更低（4.35% vs 17.39%，P<0.05）。结论：OSAHS患儿应用低温等离子手术治疗的疗效和安全性均较好，考虑可能与该方案能有效改善患儿手术相关指标、减轻机体炎症反应、改善机体免疫功能、缓解疼痛和改善睡眠情况等有关。
Abstract:
Abstract: Objective To analyze the therapeutic efficacy of low-temperature plasma surgery for children with obstructivesleep apnea-hypopnea syndrome (OSAHS) and its effects on inflammatory response, immune function, pain, and sleepquality for providing a basis for the rational treatment of OSAHS. Methods A prospective study was conducted on 92children with OSAHS from January 2021 to December 2023, and they were randomly divided into control group (n=46)and pilot group (n=46). Control group were given conventional tonsil and adenoidectomy, while observation group weregiven low-temperature plasma tonsil and adenoid ablation. These patients in both groups were followed-up for 6 months aftersurgery, and there was no lost case during the follow-up period. The two groups were compared for the efficacy at 6 monthsafter surgery, surgery-related indexes, scores of visual analogue scale for pain at 1, 2, and 3 days after surgery, sleep qualitybefore and at 6 months after surgery, inflammatory response, immune function, and the occurrence of complications duringthe 6 month follow-up period. Results Compared with control group, pilot group had higher overall effective rate at 6months postoperatively (93.48% vs 78.26%, P<0.05), less intraoperative bleeding, and shorter operation andhospitalization time (P<0.05). The visual analog scale score gradually decreased in both groups at 1, 2, 3 days postoperatively, and the scores were lower in pilot group than in control group (P<0.05). Compared with those before surgery,apnea hypoventilation index and respiratory disturbance index were lower in both groups at 6 months postoperatively, withlower indicator values in the pilot group (P<0.05); while the lowest blood oxygen saturation increased in the two groups, withhigher indicator values in the pilot group (P<0.05). Compared with those before surgery, serum procalcitonin, interleukin-1β,interleukin-6, high sensitive C-reactive protein, tumor necrosis factor-α, and whole-blood CD8+ were lower in both groups at3 days postoperatively, with lower indicator values in pilot group (P<0.05); while whole-blood CD3+ , CD4+ , CD4+/CD8+were higher in both groups at 3 days postoperatively, with higher indicator values in pilot group (P<0.05). The totalcomplication rate within 6 months of follow-up was lower in pilot group than in control group (4.35% vs 17.39%, P<0.05).Conclusion Low-temperature plasma surgery is effective and safe in children with OSAHS, and it is considered that it mightbe related to its contributions to improvements in surgery-related indexes, inflammatory response, immune function, pain andsleep quality.

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备注/Memo

备注/Memo:
【收稿日期】2025-02-16【基金项目】安徽省卫生计生委科研计划项目（AHWJ2021b137）【作者简介】乔凌，主治医师，主要从事耳鼻咽喉头颈外科相关研究，E-mail: 16621713081@163.com
更新日期/Last Update: 2025-07-25