[1]孙玮竟,伍雨桐,欧明君,等.可降解高孔隙率海藻酸钠/有机复合钙盐组织工程多孔支架的制备与性能研究[J].中国医学物理学杂志,2025,42(11):1514-1522.[doi:DOI:10.3969/j.issn.1005-202X.2025.11.017]
　SUN Weijing,WU Yutong,OU Mingjun,et al.Preparation and properties of degradable and high-porosity sodium alginate/organic composite calcium salt porous scaffolds for tissue engineering[J].Chinese Journal of Medical Physics,2025,42(11):1514-1522.[doi:DOI:10.3969/j.issn.1005-202X.2025.11.017]
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可降解高孔隙率海藻酸钠/有机复合钙盐组织工程多孔支架的制备与性能研究()

《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]

卷:
42
期数:
2025年第11期
页码:
1514-1522
栏目:
生物材料与力学
出版日期:
2025-11-28

文章信息/Info

Title:
Preparation and properties of degradable and high-porosity sodium alginate/organic composite calcium salt porous scaffolds for tissue engineering
文章编号:
1005-202X（2025）11-1514-09
作者:
孙玮竟1; 伍雨桐1; 欧明君2; 辜汉浏1; 左晓玲1; 刘小莹1; 杨勇1; 王立1
1.成都医学院大健康与智能工程学院， 四川 成都 610500； 2.成都医学院临床医学院， 四川 成都 610500
Author(s):
SUN Weijing1;  WU Yutong1;  OU Mingjun2;  GU Hanliu1;  ZUO Xiaoling1;  LIU Xiaoying1;  YANG Yong1;  WANG Li1
1. School of Health and Intelligent Engineering, Chengdu Medical College, Chengdu 610500, China 2. School of Clinical Medicine, Chengdu Medical College, Chengdu 610500, China
关键词:
骨组织工程; 海藻酸钠; 柠檬酸钙复盐; 冷冻干燥; 多孔支架
Keywords:
Keywords: bone tissue engineering sodium alginate calcium citrate double salt freeze-drying porous scaffold
分类号:
R318；TQ619.7
DOI:
DOI:10.3969/j.issn.1005-202X.2025.11.017
文献标志码:
A
摘要:
本研究以海藻酸钠为基体，柠檬酸钙复盐为功能增强体，通过冷冻干燥法制备出复合多孔支架。为了深入探究该复合支架的结构与性能，利用傅里叶红外光谱仪、X射线衍射仪、扫描电子显微镜、热重分析仪等先进设备对复合支架进行全面的结构表征。同时，对其孔隙率、机械性能、溶胀率和凝胶率、体外降解率等关键性能进行系统的测试与分析。结果表明，海藻酸盐与柠檬酸钙复盐的复合属于物理复合方式；支架的孔隙率主要分布在200~600 μm，并随着复盐加入量的增多，孔径呈现出先增大后略微减小的趋势，同时孔分布也变得更加不均匀；在力学性能方面，随着复盐在支架中的含量逐渐增高，支架的力学性能得到了显著提升；然而，支架的溶胀率与凝胶率却呈现出下降的趋势；此外，海藻酸盐支架的降解率较快，而加入柠檬酸钙复盐后对其降解速率并无明显改善效果。本研究不仅为海藻酸钠/柠檬酸钙复盐复合多孔支架的制备与性能研究提供了有益的探索，同时也为其在生物医学领域的潜在应用提供了重要的参考依据。
Abstract:
Abstract: A porous composite scaffold is prepared through freeze-drying method using sodium alginate as the matrix and calcium citrate double salt as the functional enhancer. To thoroughly investigate the structure and properties of the composite scaffold, advanced instruments including Fourier transform infrared spectrometer, X-ray diffractometer, scanning electron microscope, and thermogravimetric analyzer are utilized for comprehensive structural characterization. Meanwhile, key properties such as porosity, mechanical performance, swelling ratio, gel fraction, and in vitro degradation rate are systematically tested and analyzed. The results show that the composite of sodium alginate and calcium citrate double salt is a physical complex. The porosity of the scaffold mainly ranges from 200 to 600 μm, and as the addition of double salt increases, the pore size firstly increases and then slightly decreases, while the pore distribution become more uneven. In terms of mechanical properties, with the gradual increase of the content of double salt in the scaffold, the mechanical properties of the scaffold are significantly improved. However, its swelling ratio and gel fraction exhibit decreasing trends. Additionally, the degradation rate of the alginate scaffold is relatively fast, while the addition of calcium citrate double salt does not significantly improve the degradation rate. This study not only provides valuable insights into the preparation and property research of porous composite scaffold composed of sodium alginate/calcium citrate double salt, but also offers important reference for their potential applications in biomedicine.

相似文献/References:

[1]袁宇,徐林.骨髓间充质干细胞联合3D生物打印技术治疗骨缺损的研究进展[J].中国医学物理学杂志,2021,38(1):110.[doi:DOI:10.3969/j.issn.1005-202X.2021.01.019]
　YUAN Yu,XU Lin.Research progress of bone marrow mesenchymal stem cells combined with 3D bioprinting technology in the treatment of bone defects[J].Chinese Journal of Medical Physics,2021,38(11):110.[doi:DOI:10.3969/j.issn.1005-202X.2021.01.019]

备注/Memo

备注/Memo:
【收稿日期】2025-03-21 【基金项目】四川省科技厅国际港澳台合作创新项目（21GJHZ0037）；成医英才登峰计划青年人才项目（2024qnGzn19）；成都医学院校基金（CYZYB24-11） 【作者简介】孙玮竟，研究方向：组织工程材料，E-mail:?b80827swj@163.com 【通信作者】王立，博士，副教授，研究方向：智能生物医学材料，E-mail:?iwang@cmc.edu.cn
更新日期/Last Update: 2025-12-01