[1]朱雪,李可可,刘莹,等.动态增强磁共振成像对HER-2低表达乳腺癌患者腋窝淋巴结转移的诊断价值[J].中国医学物理学杂志,2025,42(4):466-470.[doi:10.3969/j.issn.1005-202X.2025.04.007]
　ZHU Xue,LI Keke,LIU Ying,et al.Diagnostic value of dynamic contrast-enhanced magnetic resonance imaging for axillary lymphnode metastasis in breast cancer patients with low HER-2 expression[J].Chinese Journal of Medical Physics,2025,42(4):466-470.[doi:10.3969/j.issn.1005-202X.2025.04.007]
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动态增强磁共振成像对HER-2低表达乳腺癌患者腋窝淋巴结转移的诊断价值()
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《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]

卷:
42
期数:
2025年第4期
页码:
466-470
栏目:
医学影像物理
出版日期:
2025-04-20

文章信息/Info

Title:
Diagnostic value of dynamic contrast-enhanced magnetic resonance imaging for axillary lymphnode metastasis in breast cancer patients with low HER-2 expression
文章编号:
1005-202X（2025）04-0466-05
作者:
朱雪 1; 李可可 1; 刘莹 2; 马文娟 3; 董宏伟 2
1.徐州医科大学附属医院影像科，江苏 徐州 221000；2.徐州医科大学附属医院放疗科，江苏 徐州 221000；3.青海省人民医院放射科，青海 西宁 810000
Author(s):
ZHU Xue1;  LI Keke1;  LIU Ying2;  MA Wenjuan3;  DONG Hongwei2
1. Department of Imaging, the Affiliated Hospital of Xuzhou Medical University, Xuzhou 221000, China; 2. Department ofRadiotherapy, the Affiliated Hospital of Xuzhou Medical University, Xuzhou 221000, China; 3. Department of Radiology, QinghaiProvincial People’s Hospital, Xi’ning 810000, China
关键词:
动态增强磁共振成像; 乳腺癌; HER-2低表达; 腋窝淋巴结转移
Keywords:
dynamic contrast-enhanced magnetic resonance imaging;  breast cancer;  low HER-2 expression;  axillary lymphnode metastasis
分类号:
R816.91
DOI:
10.3969/j.issn.1005-202X.2025.04.007
文献标志码:
A
摘要:
目的：探讨动态增强磁共振成像（DCE-MRI）对HER-2低表达乳腺癌患者腋窝淋巴结转移（ALNM）的诊断价值。方法：选择在徐州医科大学附属医院接受治疗的297例HER-2低表达乳腺癌患者为研究对象，根据是否存在ALNM分为ALNM组（n=71）和非ALNM组（n=226）。所有患者均接受DCE-MRI检查，收集并分析动态增强参数。通过Logistic回归分析确定ALNM的影响因素，运用ROC曲线评估DCE-MRI参数在诊断ALNM中的效能。结果：两组患者在病灶分布、TNM分期、脉管侵犯方面比较差异有统计学意义（P<0.05）。两组患者在短长径之比、血管外细胞外间隙容积分数（Ve）、容积转移常数（Ktrans）、速率常数（Kep）、表观扩散系数（ADC）、信号增强比率（SER）方面比较差异有统计学意义（P<0.05）。多因素回归分析显示，短长径之比、Ve、Ktrans、Kep、ADC、SER是影响乳腺癌患者ALNM的显著因素。通过对比得出，DCE-MRI参数联合预测的曲线下面积最大，为0.976，灵敏度为91.5%，特异度为92.9%。结论：DCE-MRI是判断HER-2低表达乳腺癌患者腋窝淋巴结是否转移的有效工具，可以为临床提供重要的诊断依据。
Abstract:
Objective To evaluate the role of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) in thediagnosis of axillary lymph node metastasis (ALNM) in breast cancer patients with low HER-2 expression. Methods A totalof 297 breast cancer patients with low HER-2 expression treated at the Affiliated Hospital of Xuzhou Medical Universitywere enrolled and divided into ALNM group (n=71) and non-ALNM group (n=226) according to whether there was ALNM.All patients underwent DCE-MRI, and DCE-MRI derived parameters were collected and analyzed. Logistic regressionanalysis was used to identify the risk factors for ALNM, and the efficacy of DCE-MRI in diagnosing ALNM was assessedusing receiver operating characteristic curve. Results Significant differences were observed between two groups in lesiondistribution, TNM staging, vascular invasion, and most DCE-MRI derived parameters including short-to-long axis ratio, Ve,Ktrans, Kep, ADC and SER (all P<0.05). Multivariate regression analysis revealed that the short-to-long axis ratio, Ve, Ktrans, Kep,ADC and SER were significant risk factors for ALNM in breast cancer patients. Comparative analysis demonstrated that thecombination of DCE-MRI derived parameters yielded a maximum area under the curve of 0.976, with a sensitivity of 91.5%and a specificity of 92.9%. Conclusion DCE-MRI is an effective tool for determining the presence of ALNM in breast cancerpatients with low HER-2 expression, providing significant diagnostic evidence for clinical practice.

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备注/Memo

备注/Memo:
【收稿日期】2024-12-02【基金项目】江苏省自然科学基金（BK20211084）【作者简介】朱雪，中级技师，研究方向：影像技术，E-mail: 15152118510@163.com
更新日期/Last Update: 2025-04-30