超导心磁信号测量技术及冠心病筛查-《中国医学物理学杂志》

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Title:: Superconducting magnetocardiography signal measurement technology and coronary heart disease screening

文章编号:: 1005-202X（2024）10-1265-08

作者:: 艾海明1; 董哲2; 葛静茹3; 米旺4; 刘巍5; 1.北京开放大学科学技术学院，北京 100081； 2.中日友好医院心内科，北京 100029； 3.北京石油化工学院，北京 102617； 4.北京美尔斯通科技发展股份有限公司，北京 100086； 5.首都医科大学附属北京积水潭医院心内科，北京 100035

Author(s):: AI Haiming1; DONG Zhe2; GE Jingru3; MI Wang4; LIU Wei5; 1. College of Science and Technology, Beijing Open University, Beijing 100081, China 2. Department of Cardiology, China-Japan Friendship Hospital, Beijing 100029, China 3. Beijing Institute of Petrochemical Technology, Beijing 102617, China 4. Beijing Milestone Science & Technology Development Co., Ltd., Beijing 100086, China 5. Department of Cardiology, Beijing Jishuitan Hospital, Capital Medical University, Beijing 100035, China

关键词:: 心磁信号; 超导量子干涉器; 逆向求解; 心电信号; 冠心病

Keywords:: Keywords: magnetocardiography signal superconducting quantum interference device inverse solution electrocardiography signal coronary heart disease

分类号:: R318

DOI:: DOI:10.3969/j.issn.1005-202X.2024.10.011

文献标志码:: A

摘要:: 目的：为解决微弱心磁信号测量难题和验证临床应用效果，研究超导心磁信号测量技术及冠心病筛查。方法：首先，分析超导心磁信号测量技术原理，并构建超导心磁信号测量技术框架。其次，设计主机控制器、磁通锁定环、信号调理模块等关键电路，并研制软件系统和核心算法。最后，入组心脏健康、轻度心肌缺血和重度心肌缺血共计255例受检志愿者，分别同步心磁检查和冠脉造影术（CAG）检查进行对比试验。结果：对比试验结果表明：（1）健康受检者电流密度向量分布存在对等双极结构，心肌缺血受检者电流密度向量分布不存在对等双极结构；（2）心磁筛查与CAG筛查总体符合率[Cr]、总体Kappa值、重度缺血符合率、轻度缺血符合率、阴性符合率分别为86.22%、78.21%、86.79%、84.09%、86.67%；（3）心磁筛查结果真实性评价指标即敏感度、特异度、阳性率、阴性率、阳性似然比、阴性似然比分别为87.16%、84.41%、86.00%、86.67%、5.98、0.08。结论：心磁筛查和CAG筛查在心肌缺血诊断方面具有较高的符合率和一致性，超导心磁信号测量技术是一种准确又可靠的冠心病筛查方法。

Abstract:: Abstract: Objective To research superconducting magnetocardiography signal measurement technology and coronary heart disease screening for solving the difficulties in weak magnetocardiography signal measurement, and to verify the value of clinical application. Methods The principle of superconducting magnetocardiography signal measurement technology was analyzed for constructing a framework for superconducting magnetocardiography signal measurement technology. Then, the key circuits such as the host controller, magnetic flux-locked loop, and signal conditioning module were designed, and software systems and core algorithms were developed. Finally, a total of 255 volunteers with healthy hearts, mild myocardial ischemia and severe myocardial ischemia were enrolled in the study, and a comparative experiment was performed between synchronous magnetocardiography and coronary angiography (CAG). Results The peer-to-peer bipolar structure was only observed in the current density vector distribution of healthy subjects instead of myocardial ischemia subjects. The overall coincidence rate, total Kappa value, severe ischemia coincidence rate, mild ischemia coincidence rate and negative coincidence rate of magnetocardiography with CAG were 86.22%, 78.21%, 86.79%, 84.09% and 86.67%, respectively. Magnetocardiography had a sensitivity, specificity, positive rate, negative rate, positive likelihood ratio and negative likelihood ratio of 87.16%, 84.41%, 86.00%, 86.67%, 5.98 and 0.08, respectively. Conclusion Magnetocardiography has a high coincidence rate and consistency with CAG in the diagnosis of myocardial ischemia. Superconducting magnetocardiography signal measurement technology can be served as an accurate and reliable screening method for coronary heart diseases.

《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]

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