[1]朱林娜,王国祥,王讯,等.基于综合损伤程度的大鼠颅脑前后向-侧向碰撞 HIC 关系[J].中国医学物理学杂志,2025,42(3):406-414.[doi:10.3969/j.issn.1005-202X.2025.03.018]
　ZHU Linna,WANG Guoxiang,WANG Xun,et al.HIC relationship of anterior-posterior and lateral-medial collisions based on the comprehensive evaluation of injury[J].Chinese Journal of Medical Physics,2025,42(3):406-414.[doi:10.3969/j.issn.1005-202X.2025.03.018]
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基于综合损伤程度的大鼠颅脑前后向-侧向碰撞 HIC 关系()
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《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]

卷:
42
期数:
2025年第3期
页码:
406-414
栏目:
生物材料与力学
出版日期:
2025-03-20

文章信息/Info

Title:
HIC relationship of anterior-posterior and lateral-medial collisions based on the comprehensive evaluation of injury
文章编号:
1005-202X(2025)03-0406-09
作者:
朱林娜; 王国祥; 王讯; 罗庆航; 熊涛; 陈秋菊; 许竞毓; 于佳; 刘盛雄
重庆理工大学药学与生物工程学院生物医学工程系,重庆 400054
Author(s):
ZHU Linna;  WANG Guoxiang;  WANG Xun;  LUO Qinghang;  XIONG Tao;  CHEN Qiuju;  XU Jingyu;  YU Jia;  LIU Shengxiong
Department of Biomedical Engineering, School of Pharmacy and Biological Engineering, Chongqing University of Technology, Chongqing 400054, China
关键词:
创伤性颅脑损伤; 头部损伤评价标准; 冲击损伤生物力学; 动物实验
Keywords:
traumatic brain injury;  head injury criterion;  impact injury biomechanics;  animal experiment
分类号:
R318.0
DOI:
10.3969/j.issn.1005-202X.2025.03.018
文献标志码:
A
摘要:
目的:探讨前后向(AP)碰撞与侧向(LM)碰撞中头部损伤评价标准(HIC)值的关系。方法:雄性 SD 大鼠 102 只,随 机分为对照组 0 m(6 只)、4 组 AP 实验组和 4 组 LM 实验组(12 只/组)。大鼠适应性训练后,采用经典 Marmarou 模型构建 颅脑 AP 碰撞与 LM 碰撞系列高度损伤模型,并测量获取各组 HIC。实验组分别于损伤前后 24 h 获取走杆实验、抓力实验, 于损伤后 24 h 获取胼胝体与脑干锥体束出血占比的数据。结果:随着 AP 组和 LM 组碰撞高度的增加,走杆实验时间和抓 力实验峰值变化均呈正相关,胼胝体和脑干锥体束的出血比例增加。根据综合损伤程度值与 HIC 数学关系可知:相同损 伤值下,LM-HIC 小于 AP-HIC,并拟合出了 AP-HIC 和 LM-HIC 的数学关系。HIC 相同时,LM 组损伤程度更为严重,同时 AP 组的头部碰撞更耐受。结论:相同 HIC,LM 组损伤程度比 AP 组更严重。AP-HIC 与 LM-HIC 之间初步显示存在线性 数学关系。实验结果有望拓展 HIC 的适用范围并达成对于颅脑 LM 碰撞损伤程度的准确评估。
Abstract:
Objective To explore the relationship between the head injury criterion (HIC) values in anterior-posterior (AP) collisions and lateral-medial (LM) collisions. Methods A total of 102 male SD rats were randomly divided into a control group of 0 m (6 rats), 4 AP groups (12 rats/group) and 4 LM groups (12 rats/group). After adaptive training, the classical Marmarou model was used to execute the brain AP and LM collisions under a series of different height impacts, and the HIC values were calculated. The experimental group data of the walk-pole test and grip strength test were collected at 24 hours before and after injury, and the data of the proportion of hemorrhage in the corpus callosum and pyramidal tracts were collected at 24 hours after injury. Results As the collision heights increased in both AP and LM groups, there were positive correlations with changes in WP test time and peak GS, and corresponding increases in the proportion of hemorrhage in the cc and py. According to the mathematical relationships between the comprehensive injury degrees and HIC values, it was found that at the same injury degree, LM-HIC value was less than AP-HIC value. A mathematical relationship between AP-HIC and LM-HIC was fitted based on the comprehensive injury degrees. At the same HIC, LM group experienced more severe injuries, and AP group was more tolerant to head collision. Conclusion The injury severity in LM group is greater than that of AP group at the same HIC. Preliminary results show there is a linear mathematical relationship between AP-HIC and LMHIC. These results can be expected to expand the application scope of HIC and achieve an accurate assessment of the LM collision severity.

备注/Memo

备注/Memo:
【收稿日期】2024-11-05 【基金项目】国家重点研发计划(2016YFC0800702-3) 【作者简介】朱林娜,研究方向:颅脑碰撞损伤生物力学机制,E-mail: 18325172829@163. com;王 国 祥 ,研 究 方 向 :颅 脑 碰 撞 损 伤生物力学机制,E-mail: 2574132838@qq.com(朱林娜与 王国祥为共同第一作者) 【通信作者】刘盛雄,博士,副教授,研究方向:颅脑碰撞损伤生物力学 机制, E-mail: shengxiongliu@cqut.edu.cn
更新日期/Last Update: 2025-03-27