[1]黄宝添,林佩贤,罗利梅,等.利用放射生物学模型比较周围型肺癌立体定向放射治疗中的3种剂量方案[J].中国医学物理学杂志,2021,38(12):1472-1476.[doi:DOI:10.3969/j.issn.1005-202X.2021.12.004]
　HUANG Baotian,LIN Peixian,LUO Limei,et al.Comparison among 3 dose schedules in stereotactic body radiotherapy for peripheral lung cancer based on radiobiological models[J].Chinese Journal of Medical Physics,2021,38(12):1472-1476.[doi:DOI:10.3969/j.issn.1005-202X.2021.12.004]
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利用放射生物学模型比较周围型肺癌立体定向放射治疗中的3种剂量方案()
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《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]

卷:
38卷
期数:
2021年第12期
页码:
1472-1476
栏目:
医学放射物理
出版日期:
2021-12-24

文章信息/Info

Title:
Comparison among 3 dose schedules in stereotactic body radiotherapy for peripheral lung cancer based on radiobiological models
文章编号:
1005-202X（2021）12-1472-05
作者:
黄宝添1; 林佩贤2; 罗利梅1; 王影1
1.汕头大学医学院附属肿瘤医院放疗科， 广东 汕头 515041； 2.汕头大学医学院第二附属医院医院感染管理科， 广东 汕头 515041
Author(s):
HUANG Baotian1;  LIN Peixian2;  LUO Limei1;  WANG Ying1
1. Department of Radiation Oncology, Cancer Hospital of Shantou University Medical College, Shantou 515041, China 2. Department of Nosocomial Infection Management, the Second Affiliated Hospital of Shantou University Medical College, Shantou 515041, China
关键词:
放射生物学模型; 周围型肺癌; 立体定向放射治疗; 剂量方案
Keywords:
radiobiological model peripheral lung cancer stereotactic body radiotherapy dose schedule
分类号:
R312；R815.6
DOI:
DOI:10.3969/j.issn.1005-202X.2021.12.004
文献标志码:
A
摘要:
目的：利用放射生物学模型比较周围型肺癌立体定向放射治疗（SBRT）中3种常见剂量方案3×15 Gy、4×12 Gy和3×18 Gy在肿瘤局部控制率（TCP）、放射性肺炎（RIP）、胸壁疼痛（CWP）和肋骨骨折（RIRF）发生概率方面的差异。方法：收集20例周围型早期肺癌的CT图像资料，分别采用3种剂量方案设计放射治疗计划，利用放射生物学模型计算每种剂量方案的TCP、RIP、CWP和RIRF概率值。结果：3种剂量方案对TCP没有显著影响；4×12 Gy剂量方案的放疗毒性最低，3×15 Gy放疗毒性稍有增高，而3×18 Gy的毒性最高；3×18 Gy剂量方案的RIP、CWP和RIRF发生概率均明显高于其它两种剂量方案。结论：3种剂量方案的TCP数值没有显著差别，4×12 Gy剂量方案的放疗毒性最低，3×18 Gy剂量方案显著增加RIP、CWP和RIRF的发生概率，建议临床治疗前应根据肿瘤与危及器官的毗邻关系选择合适的剂量方案，实施个体化治疗策略。
Abstract:
Abstract: Objective To investigate the effects of 3 common dose schedules, namely 3×15 Gy, 4×12 Gy and 3×18 Gy, in stereotactic body radiotherapy for peripheral lung cancer on tumor control probability (TCP) and the probabilities of occurrence of radiation-induced pneumonitis (RIP), chest wall pain (CWP) and radiation-induced rib fracture (RIRF) using radiobiological models. Methods The CT images of 20 cases of peripheral lung cancer were collected. Three groups of treatment plans were designed based on 3 dose schedules. The TCP and the probabilities of occurrence of RIP, CWP and RIRF in each dose schedule were calculated by radiobiological models. Results Dose schedule had trivial effects on TCP. Radiation-induced toxicities in 3×18 Gy dose schedule was the highest, followed by 3×15 Gy dose schedule and 4×12 Gy dose schedule. Moreover, the probabilities of occurrence of RIP, CWP and RIRF in 3×18 Gy dose schedule were significantly higher than those in the other 2 dose schedules. Conclusion There is no significant difference in TCP among 3 different dose schedules. The radiation-induced toxicities in 4×12 Gy dose schedule is the lowest and 3×18 Gy dose schedule results in higher probabilities of occurrence of RIP, CWP and RIRF. The adjacence between the tumor and organs-at-risk should be considered before clinical treatment for determining patient-specific dosing strategy and implementing individualized treatment.

相似文献/References:

[1]陆佳扬,黄宝添,李梅,等. 应用放射生物学模型比较早期鼻咽癌不同放疗剂量分割方案[J].中国医学物理学杂志,2019,36(6):626.[doi:DOI:10.3969/j.issn.1005-202X.2019.06.002]
　LU Jiayang,HUANG Baotian,LI Mei,et al. Comparison of different fractionation regimens for early-stage nasopharyngeal carcinoma using radiobiological model[J].Chinese Journal of Medical Physics,2019,36(12):626.[doi:DOI:10.3969/j.issn.1005-202X.2019.06.002]
[2]冀鲲鹏,任基伟,靳宏星.能谱CT扫描在周围型肺癌分型中的应用[J].中国医学物理学杂志,2020,37(5):608.[doi:10.3969/j.issn.1005-202X.2020.05.015]
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[4]黄宝添,林佩贤.周围型肺癌立体定向放射治疗中采用实体肿瘤靶区推量技术的可行性研究—基于剂量学分析[J].中国医学物理学杂志,2023,40(3):272.[doi:DOI:10.3969/j.issn.1005-202X.2023.03.003]
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备注/Memo

备注/Memo:
【收稿日期】2021-09-02 【基金项目】国家自然科学基金（81602667） 【作者简介】黄宝添，硕士，高级工程师，研究方向：肿瘤放射物理，E-mail: hbt830910@126.com
更新日期/Last Update: 2021-12-24