[1]崔相利,张建光,卢晓明,等.质子治疗技术的发展及其挑战[J].中国医学物理学杂志,2022,39(4):404-408.[doi:DOI:10.3969/j.issn.1005-202X.2022.04.002]
　CUI Xiangli,ZHANG Jianguang,et al.Development and challenges of proton therapy[J].Chinese Journal of Medical Physics,2022,39(4):404-408.[doi:DOI:10.3969/j.issn.1005-202X.2022.04.002]
点击复制

质子治疗技术的发展及其挑战()
分享到：

《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]

卷:
39卷
期数:
2022年第4期
页码:
404-408
栏目:
医学放射物理
出版日期:
2022-04-27

文章信息/Info

Title:
Development and challenges of proton therapy
文章编号:
1005-202X（2022）04-0404-05
作者:
崔相利1; 2; 张建光3; 卢晓明4; 胡漫5
1.中国科学院合肥物质科学研究院/健康与医学技术研究所/医学物理与技术安徽省重点实验室， 安徽 合肥 230031； 2.中国科学院合肥肿瘤医院放疗科， 安徽 合肥230031； 3.山东省淄博岜山万杰医院肿瘤科三病区， 山东 淄博 255213； 4.合肥离子医学中心， 安徽 合肥 230088； 5.山东省肿瘤医院放疗科， 山东 济南 250117
Author(s):
CUI Xiangli1;  2;  ZHANG Jianguang3;  LU Xiaoming4;  HU Man5
1. Anhui Province Key Laboratory of Medical Physics and Technology/Institute of Health and Medical Technology/Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei 230031, China 2. Department of Radiotherapy, Hefei Cancer Hospital, Chinese Academy of Sciences, Hefei 230031, China 3. Ward 3, Department of Oncology, Zibo Bashan Wanjie Hospital, Zibo 255213, China 4. Hefei Ion Medical Center, Hefei 230088, China 5. Department of Radiotherapy, Shandong Cancer Hospital, Jinan 250117, China
关键词:
质子治疗; 散射技术; 扫描技术; 放疗计划系统; 综述
Keywords:
Keywords: proton therapy scattering technique scanning technique treatment planning system review
分类号:
R318
DOI:
DOI:10.3969/j.issn.1005-202X.2022.04.002
文献标志码:
A
摘要:
质子治疗有显著的剂量学优势，布拉格峰的迅速跌落可保证肿瘤在接受相同照射剂量的同时，大大减少肿瘤周围正常组织受照射剂量，降低放疗并发症。但是质子剂量学优势能否充分转化为临床患者的获益仍然存在一定的争议。本文综述了质子治疗的历史、基础原理及其技术发展历程，并分析了质子治疗的优势和面临的挑战。
Abstract:
Abstract: Proton therapy has significant dosimetric advantages. The rapid drop-off of Bragg peak ensures that the radiation dose for normal tissues around tumor can be significantly decreased while tumor receives the same radiation dose, which can reduce the complications of radiotherapy. However, it is still controversial whether the advantage of proton dosimetry can be fully translated into the benefits of patients. Herein the history, basic principles and technological development of proton therapy are summarized, and its advantages and challenges are discussed.

相似文献/References:

[1]常城,王若曦,杜乙,等.一种新型质子治疗剂量递送系统的设计研究及模拟验证[J].中国医学物理学杂志,2019,36(7):745.[doi:DOI:10.3969/j.issn.1005-202X.2019.07.001]
　CHANG Cheng,WANG Ruoxi,DU Yi,et al.Design and verification of a new compact dose delivery system for proton therapy[J].Chinese Journal of Medical Physics,2019,36(4):745.[doi:DOI:10.3969/j.issn.1005-202X.2019.07.001]
[2]汪金龙,屈卫卫,谢树青,等. 扫描治疗头的蒙特卡罗模型研究[J].中国医学物理学杂志,2019,36(9):1001.[doi:DOI:10.3969/j.issn.1005-202X.2019.09.002]
　WANG Jinlong,QU Weiwei,XIE Shuqing,et al. Investigation of a Monte Carlo model of scanning nozzle[J].Chinese Journal of Medical Physics,2019,36(4):1001.[doi:DOI:10.3969/j.issn.1005-202X.2019.09.002]
[3]闫卓,徐榭,陈志.基于蒙特卡洛方法和数字体模的质子治疗设施屏蔽优化设计[J].中国医学物理学杂志,2020,37(12):1482.[doi:DOI:10.3969/j.issn.1005-202X.2020.12.002]
　YAN Zhuo,X. George XU,CHEN Zhi,et al.Shielding optimization of proton therapy facilities based on Monte Carlo simulations and voxelized human phantoms[J].Chinese Journal of Medical Physics,2020,37(4):1482.[doi:DOI:10.3969/j.issn.1005-202X.2020.12.002]
[4]李国栋,王明,薛景硕,等.边缘场存在时磁共振图像引导质子治疗中束流轨迹校正与剂量分布[J].中国医学物理学杂志,2024,41(6):661.[doi:DOI:10.3969/j.issn.1005-202X.2024.06.001]
　LI Guodong,WANG Ming,XUE Jingshuo,et al.Beam trajectory correction and dose distribution in the presence of fringe fields in magnetic resonance imaging-guided proton therapy[J].Chinese Journal of Medical Physics,2024,41(4):661.[doi:DOI:10.3969/j.issn.1005-202X.2024.06.001]

备注/Memo

备注/Memo:
【收稿日期】2021-10-26 【基金项目】国家重点研发计划（2018YFE0114100）；安徽省重点研究与开发计划项目（202004j07020052） 【作者简介】崔相利，副研究员，研究方向：肿瘤放射物理，E-mail: xlcui@cmpt.ac.cn 【通信作者】胡漫，主任医师，研究方向：分子功能影像和肿瘤精准放疗，E-mail: hu5770@sina.com
更新日期/Last Update: 2022-04-27