[1]付雨桐,姚黎清,欧吉兵,等.N170在阿尔兹海默病中的应用现状[J].中国医学物理学杂志,2022,39(1):95-99.[doi:DOI:10.3969/j.issn.1005-202X.2022.01.016]
　FU Yutong,YAO Liqing,OU Jibing,et al.Application status of N170 in Alzheimers disease[J].Chinese Journal of Medical Physics,2022,39(1):95-99.[doi:DOI:10.3969/j.issn.1005-202X.2022.01.016]
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N170在阿尔兹海默病中的应用现状()
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《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]

卷:
39卷
期数:
2022年第1期
页码:
95-99
栏目:
医学生物物理
出版日期:
2022-01-17

文章信息/Info

Title:
Application status of N170 in Alzheimers disease
文章编号:
1005-202X（2022）01-0095-05
作者:
付雨桐; 姚黎清; 欧吉兵; 何影; 李霖荣; 王安娟; 孔旭; 陆芳; 樊红
昆明医科大学第二附属医院康复医学部， 云南 昆明 650101
Author(s):
FU Yutong;  YAO Liqing;  OU Jibing;  HE Ying;  LI Linrong;  WANG Anjuan;  KONG Xu;  LU Fang;  FAN Hong
Department of Rehabilitation Medicine, the Second Affiliated Hospital of Kunming Medical University, Kunming 650101, China
关键词:
阿尔兹海默病; N170; 事件相关电位; 面孔识别; 综述
Keywords:
Keywords: Alzheimers disease N170 event-related potential face recognition review
分类号:
R318；R749.16
DOI:
DOI:10.3969/j.issn.1005-202X.2022.01.016
文献标志码:
A
摘要:
阿尔兹海默病（AD）患者存在面部感知障碍，N170可作为面孔刺激过程中大脑认知加工过程的标志物，利用事件相关电位评价AD患者的面孔识别和加工的缺陷是目前研究的热点，也是临床亟需解决的难点之一。本文就面孔识别的认知加工过程和事件相关电位表现特点以及AD患者的异常N170特征进行全面阐述，解析N170在AD患者中的研究现状，发现AD患者面孔识别的神经机制尚未有统一定论。提出未来医务人员应该进一步使用更敏感、统一的范式，揭示面孔识别的内隐神经心理学时间过程，更深层次地探究N170成为AD患者社会功能障碍的诊断、监测治疗进展的生物标志物证据。
Abstract:
Abstract: Patients with Alzheimers disease (AD) suffered from impaired face perception. N170 can be taken as a marker in brain cognitive processing during facial stimulation. Therefore, using event-related potential to evaluate the defects in face recognition and processing in AD patients is a hotspot of current research, and is also one of the difficulties to be solved in clinic. Herein the cognitive processing of face recognition and the characteristics of event-related potential as well as the abnormal N170 characteristics of AD patients are comprehensively described, and the research status of N170 in AD patients is analyzed. It is found that the neural mechanism of face recognition in AD patients still remains unclear. In the future, medical staff should use a more sensitive and unified paradigm to reveal the implicit neuropsychological time process of face recognition, and further explore the evidence for N170 as a biomarker in diagnosing the social dysfunctions of AD patients and monitoring the process of treatment.

备注/Memo

备注/Memo:
【收稿日期】2021-08-21 【基金项目】国家自然科学基金（81760414）；云南省康复临床医学中心脑卒中诊疗技术项目（zx2019-04-02）；云南省科技计划项目重大科技专项（2018ZF016）；国家重点研发计划（2018YFC20023301） 【作者简介】付雨桐，硕士，助教，研究方向：认知神经电生理康复，E-mail: 906363326@qq.com 【通信作者】樊红，副主任医师，研究方向：言语与语言康复治疗，E-mail: 736384504@qq.com
更新日期/Last Update: 2022-01-17