[1]陈知然,王晓红,李向斌,等.多发脑转移瘤容积旋转调强立体定向放射外科计划对比[J].中国医学物理学杂志,2021,38(12):1482-1486.[doi:DOI:10.3969/j.issn.1005-202X.2021.12.006]
 CHEN Zhiran,WANG Xiaohong,LI Xiangbin,et al.Comparison of volumetric modulated arc therapy stereotactic radiosurgery plans of multiple brain metastases[J].Chinese Journal of Medical Physics,2021,38(12):1482-1486.[doi:DOI:10.3969/j.issn.1005-202X.2021.12.006]
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多发脑转移瘤容积旋转调强立体定向放射外科计划对比()
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《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]

卷:
38卷
期数:
2021年第12期
页码:
1482-1486
栏目:
医学放射物理
出版日期:
2021-12-24

文章信息/Info

Title:
Comparison of volumetric modulated arc therapy stereotactic radiosurgery plans of multiple brain metastases
文章编号:
1005-202X(2021)12-1482-05
作者:
陈知然1王晓红2李向斌2马平平3魏伟2全红1丁轶2
1.武汉大学物理科学与技术学院, 湖北 武汉 430072; 2.华中科技大学同济医学院附属湖北省肿瘤医院放疗科, 湖北 武汉430070; 3.南华大学核科学技术学院,湖南 衡阳 421001
Author(s):
CHEN Zhiran1 WANG Xiaohong2 LI Xiangbin2 MA Pingping3 WEI Wei2 QUAN Hong1 DING Yi2
1. School of Physics and Technology, Wuhan University, Wuhan 430072, China 2. Department of Radiotherapy, Hubei Cancer Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430070, China 3. School of Nuclear Science and Technology, University of South China, Hengyang 421001, China
关键词:
转移瘤容积旋转调强放疗等中心立体定向放射外科非共面
Keywords:
Keywords: brain metastases volumetric modulated arc therapy isocenter stereotactic radiosurgery non-coplanar
分类号:
R811.1
DOI:
DOI:10.3969/j.issn.1005-202X.2021.12.006
文献标志码:
A
摘要:
【摘要】目的:通过调整容积旋转调强(VMAT)计划等中心数目及其共面条件,研究其在多发性脑转移瘤治疗中的剂量学特征,为其临床应用提供指导。方法:收集2019年在湖北省肿瘤医院治疗的多发性脑转移瘤1例,分别设计1个等中心4个非共面弧、5个等中心5个共面弧以及5个等中心5个非共面弧计划,要求处方剂量(24 Gy/3次)覆盖95%靶体积。计划评价参数包括靶区适形度指数、梯度指数、脑部放射坏死指标(V12)和低剂量区(V5)体积覆盖率。结果:VMAT单等中心非共面弧计划对比多等中心计划有着更好的靶区适形度和更小的V12,且在小体积肿瘤的治疗中有着更好的剂量跌落。结论:VMAT单等中心非共面弧计划比多等中心共面或非共面计划更适合多发性脑转移瘤。
Abstract:
Abstract: Objective To study the dosimetric characteristics of volumetric modulated arc therapy (VMAT) in the treatment of multiple brain metastases by adjusting the number of isocenters with coplanar arcs or not. Methods A case of multiple brain metastases treated in Hubei Cancer Hospital in 2019 was selected in the study. Three kinds of plans, namely single-isocenter with 4 non-coplanar arcs, 5-isocenter with 5 coplanar arcs and 5-isocenter with 5 non-coplanar arcs, were designed separately. The prescription dose (24 Gy/3 fractions) was required to cover 95% of the target volume. The evaluation parameters included target conformity index, gradient index, brain radiation necrosis index (V12) and low-dose volume coverage (V5). Results Compared with multi-isocenter plans, VMAT single-isocenter with non-coplanar arcs plan had better target conformity and smaller V12, and it had better dose falloff in the treatment for small-sized tumors. Conclusion VMAT single isocenter with non coplanar arcs plan is more suitable for multiple brain metastases than multi-isocenter plan (coplanar or non-coplanar).

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备注/Memo

备注/Memo:
【收稿日期】2021-05-25 【基金项目】国家自然科学基金(11704108) 【作者简介】陈知然,硕士,主要从事放疗剂量方面研究,E-mail: 844186044@qq.com 【通信作者】全红,副教授,博士生导师,主要从事纳米技术在肿瘤放化疗中的应用,E-mail: csp6606@sina.com;丁轶,博士,放疗物理师,主要从事放疗物理与技术方面工作,E-mail: dingyi_hbch@163.com
更新日期/Last Update: 2021-12-24