[1]张平,邓官华,戴鹏,等.剂量体积优化算法与光子优化算法在儿童全中枢调强放射治疗计划的剂量学比较[J].中国医学物理学杂志,2022,39(12):1460-1465.[doi:DOI:10.3969/j.issn.1005-202X.2022.12.002]
　ZHANG Ping,DENG Guanhua,DAI Peng,et al.Dosimetric comparison of IMRT optimization with dose volume optimizer versus photon optimizer in pediatric craniospinal irradiation[J].Chinese Journal of Medical Physics,2022,39(12):1460-1465.[doi:DOI:10.3969/j.issn.1005-202X.2022.12.002]
点击复制

剂量体积优化算法与光子优化算法在儿童全中枢调强放射治疗计划的剂量学比较()
分享到：

《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]

卷:
39卷
期数:
2022年第12期
页码:
1460-1465
栏目:
医学放射物理
出版日期:
2022-12-25

文章信息/Info

Title:
Dosimetric comparison of IMRT optimization with dose volume optimizer versus photon optimizer in pediatric craniospinal irradiation
文章编号:
1005-202X（2022）12-1460-06
作者:
张平1; 邓官华1; 戴鹏1; 罗日顺1; 罗龙辉1; 黄庆2
1.广东三九脑科医院肿瘤综合治疗中心， 广东 广州 510510； 2.广东三九脑科医院设备科， 广东 广州 510510
Author(s):
ZHANG Ping1;  DENG Guanhua1;  DAI Peng1;  LUO Rishun1;  LUO Longhui1;  HUANG Qing2
1. Department of Oncology, Guangdong Sanjiu Brain Hospital, Guangzhou 510510, China 2. Department of Equipment, Guangdong Sanjiu Brain Hospital, Guangzhou 510510, China
关键词:
儿童肿瘤; 调强放射治疗; 剂量体积优化算法; 光子优化算法; 全中枢放疗
Keywords:
Keywords: pediatric tumor intensity-modulated radiotherapy dose volume optimizer algorithm photon optimizer algorithm craniospinal irradiation
分类号:
R815.6；R312
DOI:
DOI:10.3969/j.issn.1005-202X.2022.12.002
文献标志码:
A
摘要:
目的：分析剂量体积优化（DVO）算法与光子优化（PO）算法在儿童全中枢调强放射治疗（IMRT）中的剂量学比较。方法：选择2018年7月~2020年1月于广东三九脑科医院行全中枢IMRT计划的15例儿童肿瘤患者作为研究对象，分别采用DVO算法和PO算法设计计划，比较两组计划的剂量学参数、优化效率及机器跳数。结果：与PO算法相比，DVO算法计划的靶区[D50%]和适形度指数更佳，差异有统计学意义（P<0.05），且颈段计划靶区（PTV）低于95%处方剂量的体积更低（P<0.05），但在靶区[D2%、D98%]、均匀性指数和梯度跌落指数差异无统计学意义（P>0.05）。与PO算法相比，DVO算法计划在双肺、右肾和心脏的受照剂量偏低，差异有统计学意义（P<0.05），而在其它危及器官剂量学参数差异无统计学意义（P>0.05）。与PO算法相比，DVO算法计划增加了较少的机器跳数（约63 MU），但算法优化时间翻倍，约224 s。结论：儿童全中枢IMRT计划采用DVO算法可提高靶区适形性，降低颈段PTV低于处方剂量的体积，有可能减少颈段靶区肿瘤复发率，因此建议在儿童全中枢IMRT计划中采用DVO算法优化。
Abstract:
Abstract: Objective To investigate the dosimetric characteristics between dose volume optimizer (DVO) algorithm and photon optimizer (PO) algorithm in pediatric craniospinal irradiation using intensity-modulated radiotherapy (IMRT). Methods DVO algorithm and PO algorithm were used to generate DVO plans and PO plans for 15 patients who received craniospinal irradiation using IMRT in Guangdong Sanjiu Brain Hospital from July 2018 to January 2020. The dosimetric characteristics, optimization efficiency and monitor units of DVO plans and PO plans were evaluated. Results There was no significant difference between PO plans and DVO plans in D2%, D98%, homogeneity index and gradient index of PTV (P>0.05). However, compared with PO plans, DVO plans showed better D50% and conformity index (CI) of PTV (P<0.05), and smaller volume of cervical PTV receiving lower than 95% of the prescription dose (P<0.05). The doses received by the lungs, right kidney and heart in DVO plans were lower than those in PO plans (P<0.05), whereas the doses received by the other organs-at-risk did not differ significantly between DVO plans and PO plans (P>0.05). Compared with those in PO plans, the monitor units in DVO plans was increased by an average of 63 MU, and the optimization time was increased by an average of 224 s. Conclusion The application of DVO algorithm in pediatric craniospinal irradiation using IMRT can improve the target conformity, reduce the volume of cervical PTV receiving lower than 95% of the prescription dose, and may lower the incidence of tumor recurrence. Therefore, DVO algorithm is recommended for IMRT optimization in pediatric craniospinal irradiation.

相似文献/References:

[1]史贵连,叶福丽.PTW729二维矩阵的平面剂量验证[J].中国医学物理学杂志,2015,32(02):239.[doi:10.3969/j.issn.1005-202X.2015.02.020]
[2]戴相昆,杨丰蔚,杜 镭,等.等效均匀剂量优化法在宫颈癌调强计划中的应用[J].中国医学物理学杂志,2015,32(02):290.[doi:10.3969/j.issn.1005-202X.2015.02.033]
[3]巩汉顺,王金媛,丛小虎,等.晚期胰腺癌适形、简化调强及螺旋断层放疗的剂量学评估[J].中国医学物理学杂志,2015,32(01):8.[doi:10.3969/j.issn.1005-202X.2015.01.003]
[4]曾 彪,张九堂,席许平,等.单中心上下半野技术在胸中上段食管癌放射治疗中的剂量学分布[J].中国医学物理学杂志,2015,32(03):357.[doi:10.3969/j.issn.1005-202X.2015.03.012]
[5]史贵连,叶福丽.肺癌调强放疗计划的设计[J].中国医学物理学杂志,2015,32(03):361.[doi:10.3969/j.issn.1005-202X.2015.03.013]
[6]陈炳周,路俊哲,侯 氢.不同设计方式的调强逆向治疗计划比较[J].中国医学物理学杂志,2015,32(03):391.[doi:10.3969/j.issn.1005-202X.2015.03.020]
[7]周 钢,田 野,陆雪官,等.同步加量技术应用于脑胶质瘤术后调强放疗的剂量学研究[J].中国医学物理学杂志,2014,31(02):4727.[doi:10.3969/j.issn.1005-202X.2014.02.002]
[8]宋 威,赵 迪,鹿 红,等.射野方向优化技术在胸中上段食管癌调强放疗中的应用[J].中国医学物理学杂志,2014,31(05):5109.[doi:10.3969/j.issn.1005-202X.2014.05.003]
[9]桑 勇,陈维军,狄小云,等.多叶光栅叶片宽度对鼻咽癌剂量学的影响[J].中国医学物理学杂志,2014,31(06):5240.[doi:10.3969/j.issn.1005-202X.2014.06.004]
[10]黄利生,庄婷婷,伍方财,等.鼻咽癌调强放疗Ib区剂量分析[J].中国医学物理学杂志,2014,31(06):5265.[doi:10.3969/j.issn.1005-202X.2014.06.010]

备注/Memo

备注/Memo:
【收稿日期】2022-07-19 【基金项目】广东省自然科学基金（2019A1515011943） 【作者简介】张平，工程师，研究方向：神经肿瘤放射物理，E-mail: zhangping0406@126.com 【通信作者】黄庆，工程师，研究方向：直线加速器工作原理及应用维修，E-mail: huangqing@999brain.com
更新日期/Last Update: 2022-12-23