j.issn.1005-202X.2021.06.020]
点击复制

细胞外基质刚度在肝细胞癌中的研究进展()

分享到：

《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]

Title:: Advances of research on extracellular matrix stiffness in hepatocellular carcinoma

作者:: 魏佳赟1; 2; 姚佳1; 2; 李汛1; 2; 3; 4; 5; 1.兰州大学第一临床医学院，甘肃兰州 730000； 2.甘肃省生物治疗与再生医学重点实验室，甘肃兰州 730000； 3.兰州大学第一医院普外科，甘肃兰州 730000； 4.兰州大学医学院肿瘤防治中心，甘肃兰州 730000； 5.甘肃省肝胆胰外科研究所，甘肃兰州 730000

Author(s):: WEI Jiayun1; 2; YAO Jia1; 2; LI Xun1; 2; 3; 4; 5; 1. the First Clinical Medical School, Lanzhou University, Lanzhou 730000, China 2. Key Laboratory of Biotherapy and Regenerative Medicine of Gansu Province, Lanzhou 730000, China 3. Department of General Surgery, the First Hospital of Lanzhou University, Lanzhou 730000, China 4. Center for Cancer Prevention and Treatment, School of Medicine, Lanzhou University, Lanzhou 730000, China 5. Gansu Provincial Institute of Hepatobiliary and Pancreatic Surgery, Lanzhou 730000, China

Keywords:: Keywords: extracellular matrix matrix stiffness hepatocellular carcinoma review

摘要:: 肿瘤微环境在肿瘤的发生发展中起着重要的作用，其主要的组成部分是细胞外基质，这是一个复杂的大分子网络，具有独特的物理、生化和生物力学特性。越来越多的证据表明刚度作为细胞外基质的重要生物力学属性，对肝癌细胞的生物学行为产生重要影响。具体表现在高基质刚度增强肝癌细胞的化疗耐药性、增殖及侵袭转移的能力，但是低基质刚度促进肝癌细胞干性相关标志物的表达，并且增强化疗后细胞克隆启动能力。了解基质刚度是如何影响肿瘤进展有助于开发针对肿瘤微环境的治疗干预手段。

Abstract:: Abstract: Tumor microenvironment plays an important role in tumorigenesis and development of cancer, and its main component is extracellular matrix which is a complex macromolecular network with unique physical, biochemical and biomechanical properties. More and more evidences show that stiffness, as an important biomechanical property of extracellular matrix, has a significant effect on the biological behavior of hepatocellular carcinoma cells. Specifically, high matrix stiffness enhances the chemotherapy-resistance, proliferation, invasion and metastasis of hepatocellular carcinoma cells, while low matrix stiffness promotes the expression of stemness-related markers and improves the ability of cell cloning initiation after chemotherapy. Understanding how matrix stiffness affects cancer progression helps to develop new therapeutic interventions for tumor microenvironments.

[1]刘娟,申广浩,谢康宁,等.不同波形低强度电磁场对高糖培养的肾小球系膜细胞（HBZY-1细胞株）细胞外基质合成的影响[J].中国医学物理学杂志,2016,33(7):747.[doi:10.3969/j.issn.1005-202X.2016.07.022]
　[J].Chinese Journal of Medical Physics,2016,33(6):747.[doi:10.3969/j.issn.1005-202X.2016.07.022]
[2]罗嗣昌,胥义.不同保护剂对大鼠肾脏冻融法脱细胞的影响[J].中国医学物理学杂志,2021,38(7):877.[doi:DOI:10.3969/j.issn.1005-202X.2021.07.017]
　LUO Sichang,XU Yi.Effects of different cryoprotective agents on decellularization of rat kidney by freeze-thaw method[J].Chinese Journal of Medical Physics,2021,38(6):877.[doi:DOI:10.3969/j.issn.1005-202X.2021.07.017]

备注/Memo:: 【收稿日期】2021-02-03 【基金项目】国家自然科学基金（31570509, 81872578）；甘肃省科技重大专项（1602FKDA001）；城关区科技局项目（2017SHFZ0014）【作者简介】魏佳赟，博士在读，研究方向：肝胆外科，E-mail: weijy18@lzu.edu.cn 【通信作者】李汛，博士，教授，研究方向：肝胆外科及内镜外科，E-mail: lxdr21@126.com

更新日期/Last Update: 2021-06-29