[1]杨朝生,陈慧,孙雪皎,等.结核感染T细胞斑点试验与肺部CT表现的相关性[J].中国医学物理学杂志,2020,37(9):1155-1159.[doi:10.3969/j.issn.1005-202X.2020.09.014]
　YANG Chaosheng,CHEN Hui,SUN Xuejiao,et al.Correlation between T-SPOT.TB assay and pulmonary CT findings in pulmonary tuberculosis[J].Chinese Journal of Medical Physics,2020,37(9):1155-1159.[doi:10.3969/j.issn.1005-202X.2020.09.014]
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结核感染T细胞斑点试验与肺部CT表现的相关性()
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《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]

卷:
37
期数:
2020年第9期
页码:
1155-1159
栏目:
医学人工智能
出版日期:
2020-09-25

文章信息/Info

Title:
Correlation between T-SPOT.TB assay and pulmonary CT findings in pulmonary tuberculosis
文章编号:
1005-202X（2020）09-1155-05
作者:
杨朝生1; 陈慧1; 孙雪皎1; 张东伟1; 刘琼霞1; 王丰1; 刘子声2
1. 柳州市人民医院呼吸与危重症医学科，广西柳州545000；2. 郴州市第一人民医院消化科，湖南郴州423000
Author(s):
YANG Chaosheng1;  CHEN Hui1;  SUN Xuejiao1;  ZHANG Dongwei1;  LIU Qiongxia1;  WANG Feng1;  LIU Zisheng2
1. Department of Respiratory and Critical Care Medicine, Liuzhou Peoples Hospital, Liuzhou 545000, China 2. Department of Digestion, Chenzhou No.1 Peoples Hospital, Chenzhou 423000, China
关键词:
肺结核; T细胞斑点实验; 高分辨CT
Keywords:
pulmonary tuberculosis T-SPOT.TB assay high-resolutiion CT
分类号:
R521；R814.42
DOI:
10.3969/j.issn.1005-202X.2020.09.014
文献标志码:
A
摘要:
目的：探讨活动性肺结核患者结核感染T细胞斑点试验（T-SPOT.TB）数值测定与高分辨CT（HRCT）征象评分的相 关性。方法：回顾分析52例肺结核患者，对其外周血液标本进行T-SPOT.TB数值测定，并根据其HRCT的7种典型征象分 布及范围行对上述患者的肺部CT表现进行评分，利用结核感染T-SPOT.TB数值与HRCT征象评分进行散点图绘制，统计 学软件进行相关性分析，讨论两者有无相关性。结果：52例患者肺部HRCT评分分值分布在2~52。微结节分值最大，总 分为254，平均4.88；最小为空洞，总分10，平均0.19，分值整体上成正态分布；52 例患者T-SOPT.TB所测值A抗原孔阴性 （测得值为0~5）17例，阳性（测得值>5）35例，B孔抗原阴性（测得值为0~5）14例，阳性（测得值>5）38例，T-SPOT.TB表现为 阴性所对应的HRCT征象评分均值与阳性所对应均值对比无统计学差异（不论A孔或者B孔）；从散点图看T-SOPT.TB所 测A抗原孔及B抗原孔值与HRCT征象评分值之间存在一定相关性，利用统计学计算相关系数分别为0.27（P<0.05）和 0.17（P<0.05），提示T-SOPT.TB测定值与HRCT征象评分为正相关性。结论：T-SOPT.TB与肺部CT所示肺结核病变范围 大小及程度有一定相关性。
Abstract:
Objective To investigate the relationship between the results of T-SPOT.TB assay and high-resolution CT (HRCT) sign scores of patients with active pulmonary tuberculosis (PTB). Methods The clinical information of 52 patients with PTB was retrospectively analyzed in the study. Peripheral blood samples were collected for detecting the T lymphocytes by T-SPOT.TB assay, and meanwhile the pulmonary CT findings were scored according to the 7 typical patterns, distributions and profusions of pulmonary abnormalities on HRCT images. Finally, scattered spots were drawn and the correlations between the results of T-SPOT. TB assay and HRCT sign scores were investigated by statistical software. Results The HRCT sign scores in 52 patients ranged from 2 to 52. The score of micronodules was the highest, with a total score of 254 and an average score of 4.88, while the score of the cavity was the lowest, with a total score of 10 and an average score of 0.19. Generally, the HRCT sign scores were normally distributed. The results of T-SOPT.TB assay showed that T-SPOT.TB antigen A were negative (the measured values were 0-5) in 17 cases and positive (the measured values were larger than 5) in the other samples, and that there were 14 T-SPOT.TB antigen B negative (the measured values were 0-5) cases and 38 positive (the measured values were larger than 5) cases. There was no statistical difference in the average HRCT sign score between T-SPOT.TB negative cases and T-SPOT.TB positive cases (whatever T-SPOT.TB antigen A or B). According to the drawn scatter plots, T-SPOT.TB antigens A and B detected by T-SPOT.TB were correlated with HRCT sign scores in a certain degree, and the corresponding correlation coefficients were 0.27 (P<0.05) and 0.17 (P<0.05), respectively, which suggested there was positive correlation between the results of T-SPOT.TB assay and HRCT sign scores. Conclusion T-SOPT.TB has a correlation with the range and degree of PTB lesions on HRCT image.

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备注/Memo

备注/Memo:
【收稿日期】2020-03-14 【课题基金】广西壮族自治区卫生和计划生育委员会科研课题（Z20180327）；柳州市人民医院院内立项课题（lry201908） 【作者简介】杨朝生，硕士，副主任医师，主要研究方向：肺部感染、哮喘、肺栓塞，E-mail: gdsg9999@qq.com 【通信作者】刘子声，硕士，主治医师，E-mail: wfcc1914@qq.com
更新日期/Last Update: 2020-09-25