[1]常城,王若曦,杜乙,等.一种新型质子治疗剂量递送系统的设计研究及模拟验证[J].中国医学物理学杂志,2019,36(7):745-750.[doi:DOI:10.3969/j.issn.1005-202X.2019.07.001]
　CHANG Cheng,WANG Ruoxi,DU Yi,et al.Design and verification of a new compact dose delivery system for proton therapy[J].Chinese Journal of Medical Physics,2019,36(7):745-750.[doi:DOI:10.3969/j.issn.1005-202X.2019.07.001]
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一种新型质子治疗剂量递送系统的设计研究及模拟验证()
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《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]

卷:
36卷
期数:
2019年第7期
页码:
745-750
栏目:
医学放射物理
出版日期:
2019-07-25

文章信息/Info

Title:
Design and verification of a new compact dose delivery system for proton therapy
文章编号:
1005-202X（2019）07-0745-06 Design and
作者:
常城; 王若曦; 杜乙; 岳海振; 吴昊; 张艺宝
北京大学肿瘤医院暨北京市肿瘤防治研究所放疗科/恶性肿瘤发病机制及转化研究教育部重点实验室，北京100142
Author(s):
CHANG Cheng; WANG Ruoxi;  DU Yi;  YUE Haizhen;  WU Hao;  ZHANG Yibao
Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Radiation Oncology, Peking University Cancer Hospital & Institute, Beijing 100142, China
关键词:
激光等离子体加速; 质子治疗; 治疗头系统; 流线型散射体; 蒙特卡罗模拟
Keywords:
Keywords: laser-plasma acceleration;  proton therapy;  nozzle system;  contoured scatter;  Monte Carlo simulation
分类号:
R318；R811.1
DOI:
DOI:10.3969/j.issn.1005-202X.2019.07.001
文献标志码:
A
摘要:
目的：针对激光等离子体加速的质子束流特性，设计用于剂量递送的新型紧凑治疗头系统，并通过模拟计算验证该方法的有效性与适用性。方法：基于实验上已实现的激光质子束流参数，利用散射体设计软件NEU（Nozzles with Everything Upstream）进行流线型散射体设计。通过散角选择和能散调制进一步优化剂量递送效率，并利用蒙特卡罗模拟计算软件TOPAS（TOol for PArticle Simulation）及底层的Geant4（GEometry ANd Tracking）计算引擎分析并验证激光质子通过此剂量递送方法后水模体中的剂量分布。结果：在直径6 cm、高5 cm的圆柱形靶区内，深度剂量分布平坦度在±1%以内，横向剂量分布在±3%以内。结论：此剂量递送方法及系统适用于现阶段激光质子束流特性，水模体靶区内剂量递送均匀、高效且稳定。
Abstract:
Abstract: Objective In view of the characteristics of proton beams after laser-plasma acceleration, to design a new type of compact nozzle system for dose delivery, and verify the applicability and efficiency of the proposed method by numerical simulation. Methods Based on the proton beam properties achieved in the laser-plasma acceleration, a contoured scatter was designed with the common software NEU (Nozzle with Everything Upstream). With proper selection of the divergence angle and the energy spread of the proton beams, the efficiency of dose delivery was further improved. After the dose delivery with the proposed method, the dose distribution of a water phantom was analyzed and verified with TOPAS (TOol for PArticle Simulation)/Geant4 (GEometry ANd Tracking). Results The flatness of the depth dose distribution in a cylindrical target area with a diameter of 6 cm and a height of 5 cm was within ±1%, and the lateral flatness was within ±3%. Conclusion The proposed compact nozzle system and dose delivery method are applicable to the characteristics of the laser-driven proton beam. The dose in the target areas of water phantom is able to be delivered uniformly, efficiently and robustly.

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备注/Memo

备注/Memo:
【收稿日期】2019-05-11 【基金项目】首都卫生发展科研专项（首发2018-4-1027）；北京市自然科学基金（7172048, 1184014）；教育部科技发展中心产学研创新基金- “智融兴教”基金（2018A01019）；国家自然科学基金（11505012）；北京市属医院科研培育计划项目（PX2019042, PX2016060）；四川省科技计划资助（2018HH0099）；北京市医院管理局“青苗”计划专项经费（QML20171104）【作者简介】常城，博士，主要研究方向：医学物理，E-mail: changcheng- 0730@hotmail.com 【通信作者】张艺宝，博士，高级工程师，硕士生导师，研究方向：医学物理，E-mail: ybzhang66@163.com
更新日期/Last Update: 2019-07-24