[1]何林. 延伸野调强放疗在局部晚期宫颈癌中的应用[J].中国医学物理学杂志,2019,36(8):914-917.[doi:DOI:10.3969/j.issn.1005-202X.2019.08.010]
　HE Lin. Application of extended-field intensity-modulated radiotherapy for locally advanced cervical cancer[J].Chinese Journal of Medical Physics,2019,36(8):914-917.[doi:DOI:10.3969/j.issn.1005-202X.2019.08.010]
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 延伸野调强放疗在局部晚期宫颈癌中的应用()
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《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]

卷:
36卷
期数:
2019年第8期
页码:
914-917
栏目:
医学放射物理
出版日期:
2019-08-26

文章信息/Info

Title:
 Application of extended-field intensity-modulated radiotherapy for locally advanced cervical cancer
文章编号:
1005-202X（2019）08-0914-04
作者:
 何林
 玉林市第二人民医院肿瘤一区， 广西 玉林 537000
Author(s):
 HE Lin
 Tumor Area, Yulin Second People’s Hospital, Yulin 537000, China
关键词:
 ; 延伸野调强放疗; 局部晚期宫颈癌; 无进展生存时间; 生存率
Keywords:
 ; Keywords: extended-field intensity-modulated radiotherapy;  locally advanced cervical cancer;  progression-free survival;  survival rate
分类号:
R737.33
DOI:
DOI:10.3969/j.issn.1005-202X.2019.08.010
文献标志码:
A
摘要:
 目的：研究体外延伸野调强放疗在局部晚期宫颈癌中的应用价值。方法：120例局部晚期宫颈癌患者（IIB~IVA期）随机分为对照组和观察组，各60例，对照组采用常规同步放化疗方案，观察组采用体外延伸野调强放疗联合同步化疗，5次/周，共8周，随访3年，比较总有效率和毒性反应，局部无进展生存时间（PFS）和生存率。结果：观察组总有效率明显高于对照组，差异有统计学意义（88.3% vs 73.3%, P<0.05）。两组毒性反应发生率和III~IV度百分比差异无统计学意义（P>0.05）。观察组PFS显著延长，生存率提高，差异有统计学意义（P<0.05）。结论：体外延伸野调强放疗在局部晚期宫颈癌中有较好的安全性和有效性。
Abstract:
 Abstract: Objective To study the effects of extracorporeal extended-field intensity-modulated radiotherapy for locally advanced cervical cancer. Methods A total of 120 patients with locally advanced cervical cancer of stage IIB-IVA were randomly divided into control group and observation group, with 60 cases in each group. Conventional synchronous radiochemotherapy was adopted in control group, while extracorporeal extended-field intensity-modulated radiotherapy combined with synchronous chemotherapy was adopted in observation group. The treatment was conducted 5 times per week and for 8 weeks, and the patients were followed-up for 3 years. The total effective rate, toxicity reaction, local progression-free survival and survival rate in two groups were compared. Results The total effective rate of observation group was higher than that of control group (88.3% vs 73.3%, P<0.05), while there was no statistical difference in the occurrence rate of toxicity reaction and percentage of stage III-IV between two groups (P>0.05). Compared with control group, observation group achieved a longer progression-free survival and a higher survival rate, with statistical significance (P<0.05). Conclusion Extracorporeal extended-field intensity-modulated radiotherapy for locally advanced cervical cancer is proved to be safe and effective.

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备注/Memo

备注/Memo:
 【收稿日期】2019-01-24
【作者简介】何林，副主任医师，主要研究方向：宫颈癌调强放疗，E-mail: 3569536407@qq.com
更新日期/Last Update: 2019-08-26