[1]王杰,邵凯南,陈鹏,等. Varian 23EX加速器固定剂量率旋转调强技术的Portal Dosimetry验证[J].中国医学物理学杂志,2019,36(10):1134-1138.[doi:DOI:10.3969/j.issn.1005-202X.2019.10.004]
　WANG Jie,SHAO Kainan,CHEN Peng,et al. Dose verification of constant dose rate-volumetric modulated arc therapy plan based on Varian 23EX accelerator via Portal Dosimetry[J].Chinese Journal of Medical Physics,2019,36(10):1134-1138.[doi:DOI:10.3969/j.issn.1005-202X.2019.10.004]
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 Varian 23EX加速器固定剂量率旋转调强技术的Portal Dosimetry验证()
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《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]

卷:
36卷
期数:
2019年第10期
页码:
1134-1138
栏目:
医学放射物理
出版日期:
2019-10-29

文章信息/Info

Title:
 Dose verification of constant dose rate-volumetric modulated arc therapy plan based on Varian 23EX accelerator via Portal Dosimetry
文章编号:
1005-202X（2019）10-1134-05
作者:
 王杰1; 邵凯南2; 陈鹏1; 曾嵘1; 姜琦1; 郑士明2; 闵旭红1
 1.安徽省胸科医院肿瘤放疗科， 安徽 合肥 230022； 2.浙江省肿瘤医院放射物理室， 浙江 杭州 310022
Author(s):
 WANG Jie1;  SHAO Kainan2;  CHEN Peng1;  ZENG Rong1;  JIANG Qi1;  ZHENG Shiming2;  MIN Xuhong1
 1. Department of Radiation Oncology, Anhui Chest Hospital, Hefei 230022, China; 2. Department of Radiation Physics, Zhejiang Cancer Hospital, Hangzhou 310022, China
关键词:
 ; 加速器; 固定剂量率; 旋转调强; 电子射野影像系统; 剂量验证
Keywords:
 ; accelerator;  constant dose rate;  volumetric modulated arc therapy;  electronic portal imaging device;  dose verification
分类号:
R811.1；R312
DOI:
DOI:10.3969/j.issn.1005-202X.2019.10.004
文献标志码:
A
摘要:
 目的：应用Varian公司的Portal Dosimetry系统和ScandiDos公司的Delta4三维半导体阵列对Varian 23EX加速器固定剂量率旋转调强（CDR-VMAT）计划进行验证并对比分析。方法：随机选取10例头颈部肿瘤患者、10例胸部肿瘤患者和10例腹部肿瘤患者，采用RayStation计划系统在Varian 23EX加速器上设计CDR-VMAT。照射野根据肿瘤部位合理设计，射线能量为6 MV X线，每个弧的剂量率和机架转速恒定并由计划系统优化给出。据此分别生成适用23EX自带EPID的Portal Dosimetry验证计划和适用Delta4的验证计划，按照3 mm DTA、3% Dose标准分析其Gamma通过率，并进行配对t检验。结果：10例头颈部肿瘤CDR-VMAT计划Portal Dosimetry验证和Delta4验证的Gamma通过率分别为（97.9±1.1）%和（99.9±0.2）%，P<0.05。10例胸部肿瘤CDR-VMAT计划的Gamma通过率分别为（99.5±0.7）%和（99.7±0.4）%，P=0.09。10例腹部肿瘤CDR-VMAT计划的Gamma通过率分别为（99.5±0.3）%和（99.7±0.4）%，P=0.19。结论：CDR-VMAT技术作为Varian 23EX加速器一种可选的放射治疗技术能够有效提高机器的计划执行效率，配合Varian Portal Dosimetry系统可以方便地对23EX加速器上的CDR-VMAT计划进行验证。通过与Delta4进行比较，对胸部和腹部肿瘤计划，其Gamma通过率均大于95%且无显著差异，对于头颈部肿瘤计划Gamma通过率有差异，但均满足大于95%的要求。
Abstract:
Abstract: Objective To verify and comparatively analyze the doses of constant dose rate-volumetric modulated arc therapy (CDR-VMAT) plan based on Varian 23EX accelerator using Varian Portal Dosimetry system and ScandiDos Delta4 three-dimensional semiconductor array. Methods RayStation treatment planning system was used to design CDR-VMAT plans based on Varian 23EX accelerator for randomly selected 10 head and neck cancer patients, 10 chest cancer patients and 10 abdominal cancer patients. Radiation fields were designed according to tumor location, and 6 MV X ray was adopted. The constant dose rate of each arc and constant gantry speed were optimized by treatment planning system. Every CDR-VMAT plan was used to generate two verification plans, with one for Portal Dosimetry system of electronic portal imaging device of 23EX and the other for Delta4 chamber array detector. Gamma passing rate was analyzed based on the criteria of 3 mm DTA and 3% Dose, and the results were analyzed with paired t test. Results For 10 cases of head and neck cancer, the Gamma passing rates of CDR-VMAT plan verified with Portal Dosimetry system and Delta4 were (97.9±1.1)% and (99.9±0.2)%, respectively (P<0.05). For 10 cases of chest cancer, the Gamma passing rates were (99.5±0.7)% and (99.7±0.4)%, respectively (P=0.09). For 10 cases of abdominal cancer, the Gamma pass rates were (99.5±0.3)% and (99.7±0.4)%, respectively (P=0.19). Conclusion CDR-VMAT as an additional radiotherapy option for Varian 23EX accelerator can effectively improve delivery efficiency. The combination of CDR-VMAT and Varian Portal Dosimetry system can easily achieve the verification of CDR-VMAT plan based on 23EX accelerator. The comparative analysis on Gamma passing rates show that both the Gamma passing rates of CDR-VMAT plans for chest cancer and abdominal cancer are higher than 95%, without statistical differences, while there is difference in Gamma passing rate of CDR-VMAT plans for head and neck cancer, but both the Gamma passing rates are still above 95%, satisfying clinical requirements

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备注/Memo

备注/Memo:
 【收稿日期】2019-04-13
【基金项目】国家卫生计生委医药卫生科技发展研究中心项目（W2015XR28）
【作者简介】王杰，硕士，研究方向：肿瘤放射物理，E-mail: jeas@mail.ustc.edu.cn
【通信作者】闵旭红，副主任医师，研究方向：肿瘤综合治疗，E-mail: 1320722827@qq.com
更新日期/Last Update: 2019-10-29