[1]王海洋,吴昊,耿建昊,等.直肠癌术前同步推量RapidPlan模型用于术后单一处方计划优化的改造测试[J].中国医学物理学杂志,2020,37(2):164-167.[doi:DOI:10.3969/j.issn.1005-202X.2020.02.006]
　WANG Haiyang,WU Hao,GENG Jianhao,et al.Feasibility study of applying a RapidPlan model trained with pre-surgical rectal cancer SIB plans to the optimization of post-surgical non-SIB plans[J].Chinese Journal of Medical Physics,2020,37(2):164-167.[doi:DOI:10.3969/j.issn.1005-202X.2020.02.006]
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直肠癌术前同步推量RapidPlan模型用于术后单一处方计划优化的改造测试()
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《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]

卷:
37
期数:
2020年第2期
页码:
164-167
栏目:
医学放射物理
出版日期:
2020-02-25

文章信息/Info

Title:
Feasibility study of applying a RapidPlan model trained with pre-surgical rectal cancer SIB plans to the optimization of post-surgical non-SIB plans
文章编号:
1005-202X（2020）02-0164-04
作者:
王海洋1; 吴昊1; 耿建昊1; 黄宇亮1; 李晨光1; 李玮博2; 蒋璠1; 弓健1; 项小羽1; 曹文田3; 常城1; 马文君4; 张艺宝1
1.北京大学肿瘤医院暨北京市肿瘤防治研究所放疗科/恶性肿瘤发病机制及转化研究教育部重点实验室， 北京 100142； 2.德国环境卫生研究中心，德国亥姆霍兹中心辐射医学研究所， 德国 纽贺堡 185764； 3.北京大学医学物理和工程北京市重点实验室， 北京 100871； 4.北京大学物理学院，核物理与核技术国家重点实验室， 北京 100871
Author(s):
WANG Haiyang1;  WU Hao1;  GENG Jianhao1;  HUANG Yuliang1;  LI Chenguang1;  LI Weibo2;  JIANG Fan1;  GONG Jian1;  XIANG Xiaoyu1;  CAO Wentian3;  CHANG Cheng1;  MA Wenjun4;  ZHANG Yibao1
1. Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Radiation Oncology, Peking University Cancer Hospital & Institute, Beijing 100142, China; 2. Institute of Radiation Medicine, Helmholtz Zentrum München-German Research Center for Environmental Health (GmbH), Neuherberg 185764, Germany; 3. Beijing Key Laboratory of Medical Physics and Engineering, Peking University, Beijing 100871, China; 4. School of Physics, Peking University, State Key Laboratory of Nuclear Physics and Technology, Beijing 100871, China
关键词:
直肠癌; RapidPlan; 放疗计划; 模型预测
Keywords:
Keywords: rectal tumor;  RapidPlan;  radiotherapy plan;  model prediction
分类号:
R730.55
DOI:
DOI:10.3969/j.issn.1005-202X.2020.02.006
文献标志码:
A
摘要:
目的：测试直肠癌术前同步推量RapidPlan模型用于术后单一处方计划优化的可行性，探索改造和拓展已有模型的应用方法。方法：（1）对现有直肠癌术前同步推量41.8 Gy（PTV）/50.6 Gy（PGTV）RapidPlan模型进行改造；（2）复制直肠癌术后单一PTV处方临床计划18例（45 Gy的7例，50 Gy的11例），保持布野条件、能量、加速器配置及原有剂量算法等不变，将PTV分别匹配模型中的PGTV和PTV，预测可实现的DVH区间并重新优化；（3）将自动计划靶区剂量归一至与临床计划相似后比较各剂量学参数。结果：单一处方靶区匹配模型中的PTV会导致严重的剂量热区，匹配PGTV的RapidPlan计划质量和临床计划相似或略好，但其危及器官剂量学参数的标准差均小于临床计划。结论：直肠癌术前同步推量RapidPlan模型可用于术后单一处方放疗计划的自动优化并且其质量一致性更好，但需将单一靶区匹配给模型中最高处方剂量对应的靶区结构。
Abstract:
Abstract: Objective To investigate the feasibility of applying a RapidPlan model trained with pre-surgical rectal cancer simultaneous integrated boost (SIB) plans to the optimization of post-surgical non-SIB plans, and to explore the methods to improve the existing models and extend their applications. Methods An existing RapidPlan model for pre-surgical rectal cancer SIB plans (PTV/PGTV: 41.8 Gy/50.6 Gy) was modified and used to re-optimize 18 clinical post-surgical non-SIB plans among which 7 and 11 cases were prescribed with 45 Gy and 50 Gy to PTV, respectively, without changing the original beam geometries, energies, accelerator configuration and dose volume calculation algorithm. The target structures were matched with PTV and PGTV in the model. The realizable DVH intervals were predicted, and the re-optimized plans were renormalized to achieve similar target coverage of the clinical plans before dosimetric comparison. Results Severe hot spots were caused by matching target areas of non-SIB plans to PTV in the model, while re-optimized plans could achieve similar or better plan quality with smaller standard errors of organs-at-risk dosimetric parameters, compared with the clinical plans. Conclusion RapidPlan model for pre-surgical rectal cancer SIB plans can be applied to the automatic optimization of post-surgical non-SIB plans with higher consistency in plan quality, but the target structure is needed to be matched to the high prescription target structure in SIB model.

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备注/Memo

备注/Memo:
【收稿日期】2019-09-12 【基金项目】首都卫生发展科研专项（首发2018-4-1027）；教育部科技发展中心产学研创新基金-“智融兴教”基金（2018A01019）；国家自然科学基金（11505012，11905150）；中央高校基本科研业务费/北京大学临床医学+X 青年专项（PKU2020LCXQ019）；国家重点研发计划（2019YFF01014405）；四川省科技计划（2018HH0099）；北京市自然科学基金（7172048, 1202009）；北京市属医院科研培育计划（PX2019042） 【作者简介】王海洋，硕士研究生，研究方向：放疗物理，E-mail: 823967844@qq.com 【通信作者】张艺宝，博士，高级工程师，硕士生导师，研究方向：医学物理，E-mail: ybzhang66@163.com
更新日期/Last Update: 2020-03-03