[1]刘欢,刘继辉,李发琪,等. 离体组织声学特性对高强度聚焦超声剂量学预测的影响[J].中国医学物理学杂志,2019,36(4):470-473.[doi:DOI:10.3969/j.issn.1005-202X.2019.04.019]
　LIU Huan,LIU Jihui,LI Faqi,et al. Effect of in vitro tissue acoustic properties on dose prediction of high intensity focused ultrasound[J].Chinese Journal of Medical Physics,2019,36(4):470-473.[doi:DOI:10.3969/j.issn.1005-202X.2019.04.019]
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 离体组织声学特性对高强度聚焦超声剂量学预测的影响()
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《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]

卷:
36卷
期数:
2019年第4期
页码:
470-473
栏目:
医学生物物理
出版日期:
2019-04-25

文章信息/Info

Title:
 Effect of in vitro tissue acoustic properties on dose prediction of high intensity focused ultrasound
文章编号:
1005-202X（2019）04-0470-04
作者:
 刘欢; 刘继辉; 李发琪; 刘雅璐; 郭成斌
 重庆医科大学生物医学工程学院/省部共建国家重点实验室培育基地—重庆市超声医学工程重点实验室/重庆市生物医学工程学重点实验室/重庆市微无创医学协同创新中心， 重庆 400016
Author(s):
 LIU Huan;  LIU Jihui;  LI Faqi;  LIU Yalu;  GUO Chengbin
 School of Biomedical Engineering of Chongqing Medical University/State Key Laboratory of Ultrasound Engineering in Medicine Co-founded by Chongqing and the Ministry of Science and Technology/Chongqing Collaborative Innovation Center for Minimally-invasive and Noninvasive Medicine, Chongqing 400016, China
关键词:
 ; 高强度聚焦超声; 离体牛肝组织; 声速; 声衰减; 温升
Keywords:
 ; Keywords: high intensity focused ultrasound;  in vitro bovine tissue;  sound velocity;  sound attenuation;  temperature rise
分类号:
R319；TB551
DOI:
DOI:10.3969/j.issn.1005-202X.2019.04.019
文献标志码:
A
摘要:
 应用高强度聚焦超声（HIFU）进行临床治疗时，主要依赖于有经验的医生主观确定辐照剂量。术前剂量投放预测一直是一个亟待解决的难题，但如果能准确预测温升变化，建立可靠的温度变化理论模型，将有助于为临床医生提供一定参考。本研究分别从声速、声衰减随温度变化的两个角度，介绍生物组织声学特性发生变化的原因，总结前人实验测得的组织声学特性的相关数据，分析离体牛肝组织声速、声衰减随温升的变化模型。在HIFU治疗中考虑靶区组织的声学特性变化，可为进一步修正HIFU剂量预测的理论模型提供一定理论依据。
Abstract:
 Abstract: At present, using high intensity focused ultrasound (HIFU) for clinical treatment mainly relies on experienced doctors to subjectively determine the irradiation dose. Preoperative dose prediction has always been an urgent problem to be solved. Accurately predicting the change of temperature rise rate and establishing a reliable theoretical model of temperature change could provide some reference for clinicians. Herein the reasons for the change in acoustic characteristics of biological tissues are introduced from two perspectives, namely acoustic velocity and sound attenuation changing with temperature. The relevant data of tissue acoustic characteristics measured by previous experiments are summarized, and the variation models of sound velocity and sound attenuation in in vitro bovine tissue changing with temperature rise are analyzed. The consideration of acoustic characteristics of target tissue in HIFU treatment provides a theoretical basis for the further modification of the theoretical model of HIFU dose prediction.

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备注/Memo

备注/Memo:
 【收稿日期】2018-11-28
【基金项目】国家自然科学基金（11574039）；重庆市前沿与应用基础研究计划一般项目（csct2017jcyjB0218）
【作者简介】刘欢，在读硕士，研究方向：超声医学，E-mail: hannah9489@163.com
【通信作者】李发琪，教授，博士生导师，E-mail: lifaqi70@163.com
更新日期/Last Update: 2019-04-23