下肢动脉覆膜支架边缘狭窄的血流动力学分析-《中国医学物理学杂志》

文章信息/Info

Title:: Hemodynamic analysis of edge stenosis in lower extremity artery stent grafts

作者:: 洪泱1; 程云章1; 朱清2; 刘祥坤3; 1. 上海理工大学医疗器械与食品学院，上海200093；2. 微创心脉医疗科技有限公司，上海201318；3. 上海微创医疗器械有限公司研发部，上海201203

Author(s):: HONG Yang1; CHENG Yunzhang1; ZHU Qing2; LIU Xiangkun3; 1. School of Medical Instrument and Food Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China; 2. MicroPort Endovascular Co., Ltd, Shanghai 201318, China; 3. MicroPort Scientific Corporation, Shanghai 201203, China

Keywords:: Keywords: lower extremity artery; stent graft; edge stenosis; hemodynamics; numerical simulation

摘要:: 通过建立镍钛合金覆膜支架的三维模型研究治疗下肢动脉狭窄的覆膜支架植入血管后的血流动力学情况。首先，进行有限元压握仿真，模拟8 mm直径的覆膜支架植入7 mm直径的血管后受到的径向压握变形，再提取出有限元结果，建立植入血管后的模型，进行计算流体动力学仿真分析。结果显示覆膜支架近端覆膜与血管贴壁不良，血液内渗区域的低壁面切应力占总低壁面切应力区域的28.5%，血液内渗区域的低流速区域占总低流速区域的30.1%。覆膜支架边缘的贴壁不良可能是造成支架植入后边缘狭窄的主要原因。

Abstract:: Abstract: A three-dimensional model of nitinol stent graft is established to investigate the hemodynamics after the stent graft was implanted into blood vessels for the treatment of arterial stenosis of lower extremities. The finite element crimping simulation is firstly carried out to simulate the radial crimping deformation after the stent graft with a diameter of 8 mm was implanted into the blood vessel with a diameter of 7 mm. Based on the finite element results, a computational fluid dynamic model is established for computational fluid dynamic simulation analysis. The results show that there is malapposition between the proximal stent graft and the blood vessle. The low wall shear stress region in blood infiltration area accounted for 28.5% of the total low wall shear stress region, and the low flow velocity recirculation zone in blood infiltration area accounted for 30.1% of the total low flow velocity zone. The malapposition at the edge of stent graft is likely a major contributor to edge stenosis after stent graft implantation.