[1]崔相利,张利伟,费振乐,等. 摆位误差对脑立体定向放射治疗剂量分布的影响[J].中国医学物理学杂志,2019,36(9):1008-1012.[doi:DOI:10.3969/j.issn.1005-202X.2019.09.003]
　CUI Xiangli,ZHANG Liwei,et al. Effect of setup errors on dosimetric distribution in intracranial stereotactic radiotherapy[J].Chinese Journal of Medical Physics,2019,36(9):1008-1012.[doi:DOI:10.3969/j.issn.1005-202X.2019.09.003]
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 摆位误差对脑立体定向放射治疗剂量分布的影响()
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《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]

卷:
36卷
期数:
2019年第9期
页码:
1008-1012
栏目:
医学放射物理
出版日期:
2019-09-25

文章信息/Info

Title:
 Effect of setup errors on dosimetric distribution in intracranial stereotactic radiotherapy
文章编号:
1005-202X（2019）09-1008-05
作者:
 崔相利1; 2; 张利伟1; 费振乐1; 王宏志1
 1.中国科学院合肥肿瘤医院， 安徽 合肥 230031； 2.中国科学院合肥物质科学研究院/医学物理与技术中心/医学物理与技术安徽省重点实验室， 安徽 合肥230031
Author(s):
 CUI Xiangli1;  2;  ZHANG Liwei1;  FEI Zhenle1;  WANG Hongzhi1
 1. Cancer Hospital, Chinese Academy of Sciences, Hefei 230031, China; 2. Anhui Province Key Laboratory of Medical Physics and Technology/Center of Medical Physics and Technology/Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei 230031, China
关键词:
 ; 脑立体定向放射治疗; 摆位误差; 剂量分布; 图像引导
Keywords:
 ; Keywords: intracranial stereotactic radiotherapy;  setup error;  dose distribution;  image-guided
分类号:
R815；R312
DOI:
DOI:10.3969/j.issn.1005-202X.2019.09.003
文献标志码:
A
摘要:
【摘要】目的：探讨摆位误差对脑立体定向放疗剂量分布的影响，指导改进定位方案。方法：随机选取10例脑立体定向放疗患者，借助XVI采集患者摆位后治疗前的锥形束CT（CBCT）和放疗后的CBCT，分别与计划CT配准，获得放疗前和放疗中的摆位误差。借助Xio计划系统，研究摆位误差对计划靶区（PTV）的适形度、平均剂量和最大剂量值的影响。结果：脑立体定向放疗前和放疗中的摆位误差分别为（3.40±1.14）和（0.36±0.12） mm。放疗前摆位误差使PTV的相对适形度由[1.00±0.00]降低为[0.81±0.17]（[P=0.007，t=-3.494]），使相对平均剂量改变了1.56%±1.15%（[P=0.002，t=4.304]）。放疗中摆位误差对PTV剂量分布的影响可忽略。结论：图像引导的无框架脑立体定向放射治疗在线修正摆位误差，可获得较高的几何和剂量测量精度。
Abstract:
 Abstract: Objective To investigate the effect of setup errors on dose distribution in intracranial stereotactic radiotherapy (SRT) for improving positioning scheme. Methods Ten patients receiving intracranial SRT was randomly enrolled in the study. The cone beam CT before and after radiotherapy was acquired by XVI and then was registered with planning CT to obtain the setup errors before and during radiotherapy. Moreover, Xio planning system was used to investigate the effects of setup errors on the conformity, mean dose and maximum dose of planning target areas. Results The setup errors before and during intracranial SRT were (3.40±1.14) and (0.36±0.12) mm, respectively. The relative conformity index of planning target areas was reduced from 1.00±0.00 to 0.81±0.17 (P=0.007, t=-3.494). The relative mean dose was increased by 1.56%±1.15 % (P=0.002, t=4.304). The effect of setup errors during radiotherapy on dose distribution was negligible. Conclusion Using image-guided frameless intracranial SRT with online correction of setup errors can achieve high geometric and dosimetric accuracies.

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备注/Memo

备注/Memo:
 【收稿日期】2019-05-16
【基金项目】安徽省公益性技术应用研究联动计划（1704f0804051）
【作者简介】崔相利，博士，放疗物理师，研究方向：肿瘤放射治疗物理学，E-mail: xlcui@cmpt.ac.cn
【通信作者】王宏志，硕士，研究员，E-mail: wanghz@hfcas.ac.cn
更新日期/Last Update: 2019-09-23