[1]胡晓伟,孙新臣,李金凯,等. 自动勾画轮廓软件在头颈部锥形束CT中的应用[J].中国医学物理学杂志,2019,36(3):254-258.[doi:DOI:10.3969/j.issn.1005-202X.2019.03.002]
　HU Xiaowei,SUN Xinchen,LI Jinkai,et al. Application of automatic segmentation software in head and neck cone beam CT[J].Chinese Journal of Medical Physics,2019,36(3):254-258.[doi:DOI:10.3969/j.issn.1005-202X.2019.03.002]
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 自动勾画轮廓软件在头颈部锥形束CT中的应用()
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《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]

卷:
36卷
期数:
2019年第3期
页码:
254-258
栏目:
医学放射物理
出版日期:
2019-03-25

文章信息/Info

Title:
 Application of automatic segmentation software in head and neck cone beam CT
文章编号:
1005-202X（2019）03-0254-05
作者:
 胡晓伟1; 孙新臣2; 李金凯2; 昌志刚2; 成红艳2
 1.南京医科大学特种医学系， 江苏 南京 210009； 2.南京医科大学第一附属医院放疗科， 江苏 南京210009
Author(s):
 HU Xiaowei1;  SUN Xinchen2;  LI Jinkai2;  CHANG Zhigang2;  CHENG Hongyan2
 1. Department of Special Medicine, Nanjing Medical University, Nanjing 210009, China; 2. Department of Radiation Oncology, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210009, China
关键词:
 ; 鼻咽癌; 锥形束CT; 形变配准; 刚性配准; 自动勾画轮廓软件
Keywords:
 ; Keywords: nasopharyngeal carcinoma;  cone beam CT;  deformable registration;  rigid registration;  automatic segmentation software
分类号:
R312；R811.1
DOI:
DOI:10.3969/j.issn.1005-202X.2019.03.002
文献标志码:
A
摘要:
 目的：评估应用自动勾画轮廓软件（MIM）进行头颈部锥形束CT（CBCT）靶区和危及器官自动勾画的可行性。方法：选择进行了两次放疗定位的10例鼻咽癌病例进行回顾性分析。在MIM软件系统中，通过形变配准分别将1程计划1CT和第一次治疗前扫描的1CBCT中的轮廓映射至2程治疗前扫描的2CBCT中。以2程2CT中医师勾画的结构为参考，比较两种方法勾画结果的精度，评价指标包括形状相似性指数（DSC）和豪斯多夫距离（HD）。对采用两种方法得到的结构均复制至2CT，以计划2CT为参考计划，比较两种方法勾画的靶区和危及器官与参考计划之间的剂量偏差。结果：采用1CBCT-2CBCT方法勾画的结构轮廓优于1CT-2CBCT。在1CBCT-2CBCT中除PTVnd、脊髓、晶体、视神经、视交叉、眼球和垂体外，其余结构的DSC均大于0.7，HD均小于2 cm，与参考计划的剂量偏差小于±3%。结论：除体积小于10 cm3的结构（骨性结构除外）、脊髓及PTVnd，利用MIM软件，采用1CBCT-2CBCT方法勾画的靶区和危及器官能够得到较满意的结果，能够为自适应放疗提供临床指导。
Abstract:
 Abstract: Objective To evaluate the feasibility of using automatic segmentation software (MIM) to automatically segment the target areas and organs-at-risk on head and neck cone beam CT (CBCT) image. Methods The clinical data of 10 patients with nasopharyngeal carcinoma (NPC) who were treated with radiotherapy positioning twice were analyzed retrospectively. In MIM software system, the contours of 1CT and 1CBCT scanned before the first treatment fraction were propagated to 2CBCT scanned before the second treatment fraction by deformable image registration. The segmented structures of 2CT were used as the reference to compare the precision of the two methods, and the evaluation index includes Dice similarity coefficient (DSC) and Hausdorff distance (HD). The structures obtained by the two methods were duplicated to 2CT. With 2CT plan as the reference plan, the dose deviations in target areas and organs-at-risk were compared. Results The structural contours segmented by 1CBCT-2CBCT were better than those obtained by 1CT-2CBCT. In 1CBCT-2CBCT, except for PTVnd, spinal cord, lens, optic nerve, optic chiasma, eyeball and pituitary, all the structures had DSC greater than 0.7 and HD less than 2 cm. The dose deviation between the reference plan and 1CBCT-2CBCT were less than ±3%. Conclusion With the use of MIM software, the target area and organs-at-risk, excluding the structures with volume less than 10 cm3 (except for bone structures), spinal cord and PTVnd, can be delineated by 1CBCT-2CBCT, achieving satisfactory segmentation results and providing clinical guidance for adaptive radiotherapy.

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备注/Memo

备注/Memo:
 【收稿日期】2018-11-19
【基金项目】国家自然科学基金（81472809，81502653，81672983）
【作者简介】胡晓伟，硕士，研究方向：医学物理，E-mail: 2424805446@qq.com
【通信作者】成红艳，主任医师，研究方向：放疗与放射生物学，E-mail: chenghongyanyishi@163.com
更新日期/Last Update: 2019-03-25