[1]巩汉顺,徐寿平,刘博,等.食管癌患者CBCT图像剂量计算准确性的分析评估[J].中国医学物理学杂志,2019,36(5):497-500.[doi:DOI:10.3969/j.issn.1005-202X.2019.05.001]
　GONG Hanshun,XU Shouping,LIU Bo,et al. Accuracy of dose calculation with CBCT images in patients with esophageal cancer[J].Chinese Journal of Medical Physics,2019,36(5):497-500.[doi:DOI:10.3969/j.issn.1005-202X.2019.05.001]
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食管癌患者CBCT图像剂量计算准确性的分析评估()
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《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]

卷:
36卷
期数:
2019年第5期
页码:
497-500
栏目:
医学放射物理
出版日期:
2019-05-25

文章信息/Info

Title:
 Accuracy of dose calculation with CBCT images in patients with esophageal cancer
文章编号:
1005-202X（2019）05-0497-04
作者:
 巩汉顺1; 徐寿平1; 刘博2; 蔡博宁1; 丛小虎1; 陈高翔1; 崔泽平1
 1.解放军总医院放疗科， 北京 100853； 2.北京航空航天大学宇航学院， 北京 100083
Author(s):
 GONG Hanshun1;  XU Shouping1;  LIU Bo2;  CAI Boning1;  CONG Xiaohu1;  CHEN Gaoxiang1;  CUI Zeping1
 1. Department of Radiotherapy, Chinese PLA General Hospital, Beijing 100853, China; 2. College of Astronautics, Beihang University, Beijing 100083, China
关键词:
 ; 食管癌; 锥形束CT; HU值; 剂量计算
Keywords:
 ; Keywords: esophageal cancer;  cone beam CT;  HU value;  dose calculation
分类号:
R815；R312
DOI:
DOI:10.3969/j.issn.1005-202X.2019.05.001
文献标志码:
A
摘要:
 目的：分析探讨食管癌患者利用锥形束CT（CBCT）图像进行剂量计算应用的可行性。方法：选择8例经过旋转调强放疗的食管癌患者，利用自主研发ART软件实现患者扇形束CT（kVCT）和首分次CBCT的准确形变配准及计划映射，同时采用直方图匹配方法对CBCT的HU值进行修正；将所得CBCT计划导入到原系统采用kVCT的HU-ED曲线及跳数重新完成剂量计算。结果：CBCT图像中各组织接受剂量及体积参数相对于kVCT偏差绝对值均小于1%。按照2 mm/2%/TH:10%标准，CBCT图像中各组织接受剂量相对于kVCT平均γ通过率均达99%以上。按照1 mm/1%/TH:10%标准，靶区平均γ通过率下降明显，最低为（82.59±16.16）%；各危及器官平均γ通过率仍可达98%以上。结论：本研究结果充分验证CBCT图像剂量计算精度，为自适应放疗中采用CBCT图像直接进行剂量计算奠定一定基础。
Abstract:
 Abstract: Objective To analyze the feasibility of using cone beam (CBCT) images for dose calculation in patients with esophageal cancer. Methods Eight patients receiving rotational intensity-modulated radiotherapy for esophageal cancer were enrolled in this study. Self-developed ART software was used to achieve accurate deformation registration and plan mapping of kVCT and the first fractional CBCT, and meanwhile histogram matching method was used to modify the HU values of CBCT. The obtained CBCT plans were imported into the original system. Finally, the HU-ED curve of kVCT was combined with monitor units for dose recalculation. Results The absolute deviations of dose and volume parameters of tissues in CBCT images from those in KCT images were less than 1%. According to the standard of 2 mm/2%/TH: 10%, the average gamma passing rate of each tissue received in the CBCT image relative to kVCT was over 99%. According to the standard of 1 mm/1%/TH: 10%, the mean gamma passing rates of target areas decreased significantly, with the lowest being 82.59%±16.16%, and the gamma passing rates of organs-at-risk were still above 98%. Conclusion The results fully verified the accuracy of dose calculation with CBCT image, and laid a certain foundation for direct dose calculation with CBCT images in adaptive radiotherapy.

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备注/Memo

备注/Memo:
 【收稿日期】2018-12-30
【基金项目】国家重点研发计划（2017YFC0112100）；国家自然科学基金（61601012）；解放军总医院临床科研扶持基金（2016FC-TSYS-1007）
【作者简介】巩汉顺，硕士研究生，物理师，研究方向：肿瘤精确放疗，E-mail: gonghanshun123@163.com
【通信作者】徐寿平，高级工程师，研究方向：肿瘤精确放疗，E-mail: shouping_xu@yahoo.com
更新日期/Last Update: 2019-05-23