[1]钟婷婷,张迪,陈真诚,等. 基于BP神经网络的胰岛素评价预测模型[J].中国医学物理学杂志,2018,35(11):1318-1323.[doi:DOI:10.3969/j.issn.1005-202X.2018.11.015]
 ZHONG Tingting,ZHANG Di,CHEN Zhencheng,et al. Insulin evaluation and prediction model based on back-propagation neural network[J].Chinese Journal of Medical Physics,2018,35(11):1318-1323.[doi:DOI:10.3969/j.issn.1005-202X.2018.11.015]
点击复制

 基于BP神经网络的胰岛素评价预测模型()
分享到:

《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]

卷:
35卷
期数:
2018年第11期
页码:
1318-1323
栏目:
医学生物物理
出版日期:
2018-11-18

文章信息/Info

Title:
 Insulin evaluation and prediction model based on back-propagation neural network
文章编号:
1005-202X(2018)11-1318-06
作者:
 钟婷婷1张迪1陈真诚2邹春林3朱健铭2赵飞骏2梁永波2
 1.桂林电子科技大学电子工程与自动化学院, 广西 桂林 541004; 2.桂林电子科技大学生命与环境科学学院, 广西 桂林 541004;3.广西医科大学转化医学研究中心, 广西 南宁530021
Author(s):
 ZHONG Tingting1 ZHANG Di1 CHEN Zhencheng2 ZOU Chunlin3 ZHU Jianming2 ZHAO Feijun2 LIANG Yongbo2
 1. School of Electronic Engineering and Automation, Guilin University of Electronic Technology, Guilin 541004, China; 2. School of Life and Environmental Sciences, Guilin University of Electronic Technology, Guilin 541004, China; 3. Transforming Medical Research Center, Guangxi Medical University, Nanning 530021, China
关键词:
 糖尿病胰岛素食蟹猴口服葡萄糖试验BP神经网络
Keywords:
 Keywords: diabetes mellitus insulin cynomolgus monkey oral glucose tolerance test back-propagation neural network
分类号:
R318
DOI:
DOI:10.3969/j.issn.1005-202X.2018.11.015
文献标志码:
A
摘要:
 在糖尿病的研究和治疗中,血糖异常不仅会严重影响机体生理功能,也会损伤机体组织,所以研究胰岛素评价预测模型对维持血糖平衡具有重要的临床意义。为理性地认识胰岛素对血糖的调节作用,本文通过食蟹猴口服葡萄糖耐量试验(OGTT)获得血糖-胰岛素代谢系统的相关数据,经过对数据的筛查和预处理,选择胰岛素功能评价指标作为胰岛素特征参数,根据食蟹猴的糖耐量水平,建立基于BP神经网络胰岛素预测模型,得到的胰岛素评价指标预测值与真值有较好的相关性。该模型利用血糖值和生理参数评价胰岛素分泌情况,用以评估和预测胰岛素在血糖调节过程中的作用,为糖耐量评估提供参考信息,辅助糖尿病诊断。
Abstract:
 Abstract: In the research and treatment of diabetes mellitus, abnormal blood glucose will not only seriously affect the physiological functions, but also damage the tissues. Therefore, the research of insulin evaluation and prediction model is of great clinical significance for maintaining blood glucose balance. In order to understand the effects of insulin on blood glucose regulation, the related data of blood glucose-insulin metabolism system were obtained by oral glucose tolerance test in cynomolgus monkey. After screening and preprocessing the obtained data, insulin function evaluation indexes were selected as the characteristic parameters. According to the level of glucose tolerance of cynomolgus monkey, an insulin prediction model based on back-propagation neural network was established, and the predicted values of insulin evaluation indexes had a good correlation with the true values. In the proposed model, blood glucose level and physiological parameters are used to evaluate insulin secretion, thus assessing and predicting the role of insulin in the blood sugar regulation process, which provides certain reference information for glucose tolerance assessment and assists in the diagnosis of diabetes mellitus.

相似文献/References:

[1]雍军光,阮 萍,沈洪涛,等.新型显微成像与分析系统在糖尿病患者红细胞定量研究中的应用[J].中国医学物理学杂志,2014,31(04):5081.[doi:10.3969/j.issn.1005-202X.2014.04.023]
[2]赵承奇,雷涛,罗二平,等.脉冲电磁场对糖尿病大鼠外周神经病变的影响[J].中国医学物理学杂志,2013,30(05):4431.[doi:10.3969/j.issn.1005-202X.2013.05.021]
[3]苑旺,梁媛媛,崔黎丽,等.正极性聚丙烯驻极体对糖尿病大鼠皮肤结构的影响[J].中国医学物理学杂志,2015,32(06):835.[doi:doi:10.3969/j.issn.1005-202X.2015.06.016]
 [J].Chinese Journal of Medical Physics,2015,32(11):835.[doi:doi:10.3969/j.issn.1005-202X.2015.06.016]
[4]余丽玲,陈婷,金浩宇,等.基于支持向量机和自回归积分滑动平均模型组合的血糖值预测[J].中国医学物理学杂志,2016,33(4):381.[doi:10.3969/j.issn.1005-202X.2016.04.012]
 [J].Chinese Journal of Medical Physics,2016,33(11):381.[doi:10.3969/j.issn.1005-202X.2016.04.012]
[5]王遥,霍万里,熊壮,等.TACE手术中不同站姿下铅眼镜和铅面罩对医生眼晶状体防护效果的蒙特卡洛模拟比较[J].中国医学物理学杂志,2016,33(6):553.[doi:DOI:10.3969/j.issn.1005-202X.2016.06.003]
 [J].Chinese Journal of Medical Physics,2016,33(11):553.[doi:DOI:10.3969/j.issn.1005-202X.2016.06.003]
[6]张新,谷晓芳,王培臣,等.轻离子束治疗设备注册检验关键技术问题[J].中国医学物理学杂志,2016,33(6):559.[doi:10.3969/j.issn.1005-202X.2016.06.004]
 [J].Chinese Journal of Medical Physics,2016,33(11):559.[doi:10.3969/j.issn.1005-202X.2016.06.004]
[7]江芬芬,王培,康盛伟,等. 热释光剂量片测量肺部肿瘤放疗剂量的方法[J].中国医学物理学杂志,2016,33(6):564.[doi:10.3969/j.issn.1005-202X.2016.06.005]
 [J].Chinese Journal of Medical Physics,2016,33(11):564.[doi:10.3969/j.issn.1005-202X.2016.06.005]
[8]刘洪源,彭威,杨锐,等. 锥形束CT离线校正肺癌摆位误差[J].中国医学物理学杂志,2016,33(6):573.[doi:10.3969/j.issn.1005-202X.2016.06.007]
 [J].Chinese Journal of Medical Physics,2016,33(11):573.[doi:10.3969/j.issn.1005-202X.2016.06.007]
[9]赵彪,潘香,杨毅,等. 右乳癌保乳术后瘤床同步X线和后程电子线补量调强放疗剂量学比较[J].中国医学物理学杂志,2016,33(6):576.[doi:10.3969/j.issn.1005-202X.2016.06.008]
 [J].Chinese Journal of Medical Physics,2016,33(11):576.[doi:10.3969/j.issn.1005-202X.2016.06.008]
[10]邓南,钱建庭,刁现芬,等. 基于宽带检测放疗X-光光声效应仿体实验[J].中国医学物理学杂志,2016,33(9):865.[doi:DOI:10.3969/j.issn.1005-202X.2016.09.001]
 [J].Chinese Journal of Medical Physics,2016,33(11):865.[doi:DOI:10.3969/j.issn.1005-202X.2016.09.001]
[11]楚轶,冯品,张薇,等. 稳恒磁场刺激对糖尿病动脉粥样硬化大鼠血清和主动脉中VEGF、TGF-β1、TNF-α和IL-6表达的影响[J].中国医学物理学杂志,2017,34(10):1045.[doi:DOI:10.3969/j.issn.1005-202X.2017.10.016]
 [J].Chinese Journal of Medical Physics,2017,34(11):1045.[doi:DOI:10.3969/j.issn.1005-202X.2017.10.016]
[12]郭一冰,崔栋,薛雅卓,等. 糖尿病行为量表计算工具箱的研制[J].中国医学物理学杂志,2018,35(2):195.[doi:DOI:10.3969/j.issn.1005-202X.2018.02.015]
 GUO Yibing,CUI Dong,XUE Yazhuo,et al. Development of diabetes behavioral scale calculation toolbox[J].Chinese Journal of Medical Physics,2018,35(11):195.[doi:DOI:10.3969/j.issn.1005-202X.2018.02.015]
[13]张嘉阳,黄河,刘子怡,等. 基于Gabor滤波器的糖尿病视网膜新生血管检测[J].中国医学物理学杂志,2018,35(8):968.[doi:DOI:10.3969/j.issn.1005-202X.2018.08.019]
 ZHANG Jiayang,HUANG He,LIU Ziyi,et al. Gabor filter-based detection of neovascularization due to diabetic retinopathy[J].Chinese Journal of Medical Physics,2018,35(11):968.[doi:DOI:10.3969/j.issn.1005-202X.2018.08.019]
[14]陈真诚,杜莹,邹春林,等. 基于K-Nearest Neighbor和神经网络的糖尿病分类研究[J].中国医学物理学杂志,2018,35(10):1220.[doi:DOI:10.3969/j.issn.1005-202X.2018.010.022]
 CHEN Zhencheng,DU Ying,ZOU Chunlin,et al. Classification of diabetes based on K-Nearest Neighbor and neural network[J].Chinese Journal of Medical Physics,2018,35(11):1220.[doi:DOI:10.3969/j.issn.1005-202X.2018.010.022]
[15]张迪,陈真诚,梁永波,等. 协同训练算法在无创血糖检测中的应用[J].中国医学物理学杂志,2018,35(11):1295.[doi:DOI:10.3969/j.issn.1005-202X.2018.11.011]
 ZHANG Di,CHEN Zhencheng,LIANG Yongbo,et al. Application of co-training algorithm in noninvasive blood glucose detection[J].Chinese Journal of Medical Physics,2018,35(11):1295.[doi:DOI:10.3969/j.issn.1005-202X.2018.11.011]
[16]李兰,杨伟伟,王楠. 脉冲电磁刺激对糖尿病大鼠神经病理性疼痛的影响[J].中国医学物理学杂志,2019,36(9):1082.[doi:DOI:10.3969/j.issn.1005-202X.2019.09.017]
 LI Lan,YANG Weiwei,WANG Nan. Effects of pulsed electromagnetic field stimulation on neuropathic pain in diabetic rats[J].Chinese Journal of Medical Physics,2019,36(11):1082.[doi:DOI:10.3969/j.issn.1005-202X.2019.09.017]

备注/Memo

备注/Memo:
 【收稿日期】2018-06-18
【基金项目】国家自然科学基金重大科研仪器研制项目(61627807);广西自然科学基金(2017GXNSFGA198005);国家重点研发计划课题(2016YFC1305703);广西自然科学基金青年基金项目(2016GXNSFBA380145);广西自动检测技术与仪器重点实验室主任基金(YQ17118);广西信息科学实验中心一般项目(YB1513)
【作者简介】钟婷婷,硕士研究生在读,研究方向:生物传感与智能仪器,E-mail: zhongt789@126.com
【通信作者】陈真诚,教授,博士生导师,主要研究方向:生物传感与智能仪器,E-mail: chenzhcheng@163.com;朱健铭,博士,副教授,硕士生导师,研究方向:生物传感与智能仪器,生物医学信号处理,E-mail: zjmcsu@126.com
更新日期/Last Update: 2018-11-22