[1]郭冉,张艺宝,李明辉,等. 调强计划验证通过率的影响因素分析[J].中国医学物理学杂志,2018,35(10):1117-1121.[doi:DOI:10.3969/j.issn.1005-202X.2018.10.001]
　GUO Ran,ZHANG Yibao,LI Minghui,et al. Factors affecting the passing rate of intensity-modulated radiotherapy plans[J].Chinese Journal of Medical Physics,2018,35(10):1117-1121.[doi:DOI:10.3969/j.issn.1005-202X.2018.10.001]
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 调强计划验证通过率的影响因素分析()
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《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]

卷:
35卷
期数:
2018年第10期
页码:
1117-1121
栏目:
医学放射物理
出版日期:
2018-10-25

文章信息/Info

Title:
 Factors affecting the passing rate of intensity-modulated radiotherapy plans
文章编号:
1005-202X（2018）10-1117-05
作者:
 郭冉1; 张艺宝2; 李明辉1; 李云东3; 戴建荣1
 1.国家癌症中心/国家肿瘤临床医学研究中心/中国医学科学院北京协和医学院肿瘤医院， 北京 100021； 2.北京大学肿瘤医院暨北京市肿瘤防治研究所放疗科/恶性肿瘤发病机制及转化研究教育部重点实验室， 北京 100142； 3.济宁市第一人民医院， 山东 济宁 272011
Author(s):
 GUO Ran1;  ZHANG Yibao2;  LI Minghui1;  LI Yundong3;  DAI Jianrong1
 1. National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China; 2. Department of Radiation Oncology, Peking University Cancer Hospital & Institute/Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Beijing 100142, China; 3. Jining NO.1 People’s Hospital, Jining 272011, China
关键词:
 ; 计划验证; PTW 729矩阵; 调强放疗
Keywords:
 ; Keywords: plan quality assurance;  PTW 729 detector array;  intensity-modulated radiotherapy
分类号:
R811.1
DOI:
DOI:10.3969/j.issn.1005-202X.2018.10.001
文献标志码:
A
摘要:
 目的：探讨计划验证通过率的影响因素。 方法：选取Pinnacle计划系统设计的68例静态调强计划。将所有射野归到机架0°后利用PTW 729电离室矩阵、固体水模体基于Synergy加速器测量剂量分布，并使用PTW VeriSoft软件分析其与理论值差异。分别以Local和Max方式分析在3 mm/3%标准下的 Gamma通过率并比较，然后分析机器跳数、子野数目、子野平均面积、子野面积的变异系数与Local通过率的相关性；回归得到通过率与各影响因素间的线性关系。 结果：所有计划Local通过率均低于Max（P<0.01）；头颈部通过率与其他部位通过率差异存在显著统计学意义（P<0.01）；Local通过率与治疗部位、子野数目、子野面积变异系数存在线性关系。 结论：Local通过率显著低于Max；头颈部计划通过率低于其他部位；根据计划的子野数目、机器跳数可以初步判断计划通过率；治疗部位、子野数目、子野面积的变异系数是影响Local通过率的主要因素，多重线性回归方程能对计划设计及选择起一定的指导作用。
Abstract:
 Abstract: Objective To investigate the factors which affects the passing rate of intensity-modulated radiotherapy (IMRT) plans. Methods A total of 68 static IMRT plans designed by Pinnacle treatment planning systems were selected. After all radiation fields were normalized to gantry angle 0°, the dose distributions were measured with PTW 729 chamber array and solid water phantom based on Synergy accelerator. Then PTW VeriSoft software was used to compare the differences between measured results and computed values. Using 3 mm/3% criteria, the Gamma passing rates of Local and Max were analyzed and compared. The correlations between the passing rate of Local and various factors, such as monitor unit, the number of segments, the mean area of segments and the coefficient of variation of segments area, were analyzed. Regression analysis was used to obtain the linear relationship between the passing rate and the affecting factors. Results The passing rates of Local were lower than those of Max for all plans (P<0.01). The passing rates of head and neck plans were significantly different from other sites, with statistical significances (P<0.01). The passing rates of Local had linear relationships with the treatment sites, the number of segments and the coefficient of variation of segments area. Conclusion The passing rate of Local is significantly lower than that of Max. Compared with plans for other sits, head and neck plan has a lower passing rate. The passing rates of Local can be preliminary estimated by monitor unit and the number of segment. Treatment sites, the number of segments and the coefficient of variation of segments area are the main factors that affect the passing rates of Local. Multiple linear regression equations can provide some guidance for the design and selection of optimal plans.

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备注/Memo

备注/Memo:
 【收稿日期】2018-06-26
【基金项目】国家自然科学基金（11505012）；首都卫生发展科研专项（首发2018-4-1027）；北京市自然科学基金（7172048，1174016，1184014）；北京大学医学科技创新平台发展基金—青年培育基金资助项目（BMU2017PY028）；瓦里安科研合作基金（Strategies for RapidPlan Model Adaptation）
【作者简介】郭冉，主管技师，研究方向：医学物理，E-mail: guorann@126.com
【通信作者】戴建荣，博士，二级研究员，研究方向：治疗计划的优化算法、图像引导放疗等，E-mail: dai_jianrong@163.com
更新日期/Last Update: 2018-10-22