[1]雷怀宇,张书旭,张国前,等. 保护颈动脉鞘的局部晚期鼻咽癌IMRT计划对靶区及危及器官剂量的影响[J].中国医学物理学杂志,2018,35(11):1252-1256.[doi:DOI:10.3969/j.issn.1005-202X.2018.11.003]
 LEI Huaiyu,ZHANG Shuxu,ZHANG Guoqian,et al. Effects of carotid sheath-sparing intensity-modulated radiotherapy for locally advanced nasopharyngeal carcinoma on doses of target areas and organs-at-risk[J].Chinese Journal of Medical Physics,2018,35(11):1252-1256.[doi:DOI:10.3969/j.issn.1005-202X.2018.11.003]
点击复制

 保护颈动脉鞘的局部晚期鼻咽癌IMRT计划对靶区及危及器官剂量的影响()
分享到:

《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]

卷:
35卷
期数:
2018年第11期
页码:
1252-1256
栏目:
医学放射物理
出版日期:
2018-11-18

文章信息/Info

Title:
 Effects of carotid sheath-sparing intensity-modulated radiotherapy for locally advanced nasopharyngeal carcinoma on doses of target areas and organs-at-risk
文章编号:
1005-202X(2018)11-1252-05
作者:
 雷怀宇张书旭张国前王琳婧王锐濠张全彬李萍林晓辉
 广州医科大学附属肿瘤医院放疗中心, 广东 广州 510095
Author(s):
 LEI Huaiyu ZHANG Shuxu ZHANG Guoqian WANG Linjing WANG Ruihao ZHANG Quanbin LI Ping LIN Xiaohui
 Radiotherapy Center, Cancer Center of Guangzhou Medical University, Guangzhou 510095, China
关键词:
 鼻咽癌调强放疗颈动脉鞘保护放射治疗剂量
Keywords:
 Keywords: nasopharyngeal carcinoma intensity-modulated radiotherapy carotid sheath-sparing radiotherapy dose
分类号:
R730.55
DOI:
DOI:10.3969/j.issn.1005-202X.2018.11.003
文献标志码:
A
摘要:
 【摘 要】 目的:探讨保护颈动脉鞘的局部晚期鼻咽癌调强放疗(IMRT)计划对靶区及危及器官剂量的影响。 方法:对10例局部晚期鼻咽癌患者行回顾性分析,分别设计常规IMRT计划及保护颈动脉鞘的IMRT计划。对PGTVnx和PCTV1的平均剂量(Dmean)、D98%、D50%、D5%、D2%、适形度指数、均匀性指数,颈动脉鞘和危及器官剂量进行评价。 结果:与常规IMRT计划相比,保护颈动脉鞘的IMRT计划中PGTVnx的适形度指数、均匀性指数,PCTV1的D50%、Dmean,颈动脉鞘的Dmax、Dmean,脊髓的Dmean,以及脑干的V40、Dmean均有所降低,有统计学差异(P<0.05);其它指标比较无统计学差异。 结论:保护颈动脉鞘的局部晚期鼻咽癌IMRT计划能保证靶区剂量覆盖,降低颈动脉鞘和脑干的剂量,同时,计划的剂量分布也更为合理
Abstract:
 Abstract: Objective To investigate the effects of carotid sheath-sparing intensity-modulated radiotherapy (IMRT) on the doses of target areas and organs-at-risk (OAR) in patients with locally advanced nasopharyngeal carcinoma (NPC). Methods A retrospective dosimetric analysis was performed on 10 patients with locally advanced NPC. Two plans, namely routine IMRT plan and carotid sheath-sparing IMRT plan, were designed for each patient. The mean dose (Dmean), D98%, D50%, D5%, D2%, conformity index and homogeneity index of planning gross target volume (PGTVnx) and planning clinical target volume (PCTV1) as well as the doses of the carotid sheath and OAR were evaluated. Results The conformity index and homogeneity index of PGTVnx, D50% and Dmean of PCTV1, Dmax and Dmean of carotid sheath, Dmean of spinal cord, and V40 and Dmean of brain stem in carotid sheath-sparing IMRT plan were significantly lower than those in routine IMRT plan, with statistical differences (P<0.05). No statistical differences were found in other dosimetric indexes. Conclusion Carotid sheath-sparing IMRT plan for locally advanced NPC can significantly reduce the doses of carotid sheath and brain stem without affecting target coverage, and achieve a superior dose distribution.

相似文献/References:

[1]陈广涛,汪 淇,刘亚强,等.TrueBeam加速器射野准直器跟随功能在鼻咽癌固定野调强放疗和容积旋转调强放疗中的应用[J].中国医学物理学杂志,2014,31(03):4865.[doi:10.3969/j.issn.1005-202X.2014.03.005]
[2]潘宇辉,陈榕钦,柏朋刚,等.鼻咽癌调强放射治疗前后腮腺体积及空间几何位置变化研究[J].中国医学物理学杂志,2014,31(05):5120.[doi:10.3969/j.issn.1005-202X.2014.05.005]
[3]张俊俊,邱小平,李奇欣,等.ArcCheck系统在鼻咽癌容积旋转调强剂量验证中的应用[J].中国医学物理学杂志,2014,31(05):5136.[doi:10.3969/j.issn.1005-202X.2014.05.009]
[4]桑 勇,陈维军,狄小云,等.多叶光栅叶片宽度对鼻咽癌剂量学的影响[J].中国医学物理学杂志,2014,31(06):5240.[doi:10.3969/j.issn.1005-202X.2014.06.004]
[5]黄利生,庄婷婷,伍方财,等.鼻咽癌调强放疗Ib区剂量分析[J].中国医学物理学杂志,2014,31(06):5265.[doi:10.3969/j.issn.1005-202X.2014.06.010]
[6]易金玲,金献测,周永强,等.鼻咽癌IMRT与VMAT治疗的计划与剂量验证比较研究[J].中国医学物理学杂志,2013,30(01):3859.[doi:10.3969/j.issn.1005-202X.2013.01.006]
[7]金献测,易金玲,周永强,等.鼻咽癌同步加量调强放射治疗新的计划质量评估指标研究[J].中国医学物理学杂志,2013,30(02):3978.[doi:10.3969/j.issn.1005-202X.2013.02.004]
[8]蒋晓芹,段宝风,艾平,等.基于图谱库的自动轮廓勾画软件(ABAS)在鼻咽癌调强放疗中的应用[J].中国医学物理学杂志,2013,30(02):3997.[doi:10.3969/j.issn.1005-202X.2013.02.008]
[9]张达光,蒋胜鹏,李智华,等.鼻咽癌调强放疗中解剖结构改变及剂量分布变化的研究[J].中国医学物理学杂志,2013,30(04):4239.[doi:10.3969/j.issn.1005-202X.2013.04.006]
[10]杨海燕,王军良,周振山,等.AAA算法和PBC算法在鼻咽癌调强放疗中剂量分布的比较[J].中国医学物理学杂志,2013,30(04):4245.[doi:10.3969/j.issn.1005-202X.2013.04.008]
[11]张晓辉,王淑侠,徐卫平,等. PET/CT增强在鼻咽癌头颈部淋巴结转移的应用价值[J].中国医学物理学杂志,2016,33(9):939.[doi:10.3969/j.issn.1005-202X.2016.09.014]
 [J].Chinese Journal of Medical Physics,2016,33(11):939.[doi:10.3969/j.issn.1005-202X.2016.09.014]
[12]蒋璐,邱小平,单国平,等. 鼻咽癌放疗中摆位误差及解剖结构变化对剂量学的影响[J].中国医学物理学杂志,2017,34(4):348.[doi:DOI:10.3969/j.issn.1005-202X.2017.04.006]
[13]胡邦,唐承佩,刘小芳,等. 基于等效均匀剂量的目标函数对鼻咽癌调强放疗中颞叶的保护[J].中国医学物理学杂志,2017,34(5):472.[doi:DOI:10.3969/j.issn.1005-202X.2017.05.008]
[14]王占宇,曾自力,谭军文. 基于电子射野影像系统的鼻咽癌调强放疗摆位误差纠正及其应用[J].中国医学物理学杂志,2017,34(9):887.[doi:DOI:10.3969/j.issn.1005-202X.2017.09.006]
 [J].Chinese Journal of Medical Physics,2017,34(11):887.[doi:DOI:10.3969/j.issn.1005-202X.2017.09.006]
[15]苏欢繁,全红,梁志文,等.鼻咽癌放疗中3种调强技术对摆位误差的敏感性[J].中国医学物理学杂志,2017,34(11):1102.[doi:DOI:10.3969/j.issn.1005-202X.2017.11.005]
 SU Huanfan,QUAN Hong,LIANG Zhiwen,et al. Sensitivity of 3 kinds of intensity-modulated radiotherapy techniques to setup errors in radiotherapy for nasopharyngeal carcinoma[J].Chinese Journal of Medical Physics,2017,34(11):1102.[doi:DOI:10.3969/j.issn.1005-202X.2017.11.005]
[16]刘礼东,杨振,邱小平,等. 利用Delta4对放疗计划进行剂量体积直方图评价的可行性研究[J].中国医学物理学杂志,2018,35(1):25.[doi:DOI:10.3969/j.issn.1005-202X.2018.01.006]
 LIU Lidong,YANG Zhen,QIU Xiaoping,et al. Feasibility of Delta4 for plan evaluation based on dose-volume histogram[J].Chinese Journal of Medical Physics,2018,35(11):25.[doi:DOI:10.3969/j.issn.1005-202X.2018.01.006]
[17]赵洪利,刘晖,钟亚华,等. TomoDirect技术在鼻咽癌放疗中的剂量学研究[J].中国医学物理学杂志,2018,35(2):166.[doi:DOI:10.3969/j.issn.1005-202X.2018.02.009]
 ZHAO Hongli,LIU Hui,ZHONG Yahua,et al. Dosimetric study of TomoDirect technology in radiotherapy for nasopharyngeal carcinoma[J].Chinese Journal of Medical Physics,2018,35(11):166.[doi:DOI:10.3969/j.issn.1005-202X.2018.02.009]
[18]刘国才,官文静,田娟秀,等. 集成自适应回归核的肿瘤生物靶区随机游走勾画方法[J].中国医学物理学杂志,2018,35(7):758.[doi:DOI:10.3969/j.issn.1005-202X.2018.07.004]
 LIU Guocai,GUAN Wenjing,TIAN Juanxiu,et al. A random walk method with adaptive regression-kernel for delineation of biological target volumes of tumors[J].Chinese Journal of Medical Physics,2018,35(11):758.[doi:DOI:10.3969/j.issn.1005-202X.2018.07.004]
[19]滕建建,石锦平,张利文,等. 鼻咽癌容积调强剂量验证与计划复杂性的相关性[J].中国医学物理学杂志,2018,35(7):781.[doi:DOI:10.3969/j.issn.1005-202X.2018.07.008]
 TENG Jianjian,SHI Jinping,ZHANG Liwen,et al. Correlation between dose verification and plan complexity of volumetric modulated arc therapy for nasopharyngeal carcinoma[J].Chinese Journal of Medical Physics,2018,35(11):781.[doi:DOI:10.3969/j.issn.1005-202X.2018.07.008]
[20]杨海松,聂晓历,刘利彬,等. 鼻咽癌螺旋断层调强放疗中优化MVCT扫描范围的可行性[J].中国医学物理学杂志,2018,35(8):874.[doi:DOI:10.3969/j.issn.1005-202X.2018.08.002]
 YANG Haisong,NIE Xiaoli,LIU Libin,et al. Feasibility on optimizing MVCT scan range in tomotherapy of nasopharyngeal carcinoma[J].Chinese Journal of Medical Physics,2018,35(11):874.[doi:DOI:10.3969/j.issn.1005-202X.2018.08.002]

备注/Memo

备注/Memo:
 【收稿日期】2018-05-02
【基金项目】广州医科大学青年科学项目(2016A25)
【作者简介】雷怀宇,硕士,主要从事肿瘤放射治疗研究,E-mail:623703018@qq.com
【通信作者】张书旭,博士,教授/主任技师,博士生导师,主要从事肿瘤放射物理学和医学图像应用研究,E-mail: gthzsx@163.com
更新日期/Last Update: 2018-11-22