[1]苏克阳,曾景阳,谢文钦,等. 近似熵在脑电监测麻醉深度中的应用[J].中国医学物理学杂志,2019,36(1):117-120.[doi:DOI:10.3969/j.issn.1005-202X.2019.01.023]
　SU Keyang,ZENG Jingyang,XIE Wenqin,et al. Application of EEG approximate entropy in monitoring the depth of anesthesia[J].Chinese Journal of Medical Physics,2019,36(1):117-120.[doi:DOI:10.3969/j.issn.1005-202X.2019.01.023]
点击复制

 近似熵在脑电监测麻醉深度中的应用()
分享到：

《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]

卷:
36卷
期数:
2019年第1期
页码:
117-120
栏目:
医学生物物理
出版日期:
2019-01-25

文章信息/Info

Title:
 

Application of EEG approximate entropy in monitoring the depth of anesthesia
文章编号:
1005-202X（2019）01-0117-04
作者:
 苏克阳; 曾景阳; 谢文钦; 颜景佳; 谢文吉
 泉州市第一医院麻醉科， 福建 泉州 362000
Author(s):
 SU Keyang;  ZENG Jingyang;  XIE Wenqin;  YAN Jingjia;  XIE Wenji
 Department of Anesthesiology, Quanzhou First Hospital, Quanzhou 362000, China
关键词:
 ; 脑电图; 近似熵; 麻醉深度; 丙泊酚; 血浆
Keywords:
Keywords: electroencephalogram;  approximate entropy;  depth of anesthesia;  propofol;  plasma
分类号:
R614.2
DOI:
DOI:10.3969/j.issn.1005-202X.2019.01.023
文献标志码:
A
摘要:
 目的：探究脑电近似熵在麻醉深度监测中的应用。 方法：以2017年1月~2018年1月择期行全麻手术的80例患者为研究对象，测定所有患者麻醉前、麻醉诱导5 min、术中60 min、麻醉苏醒时脑电双频指数（BIS）、脑电近似熵，且观察不同丙泊酚血浆浓度、改良镇静/警觉评分（MOAA/S）BIS值、脑电近似熵值的变化情况，Pearson相关性分析BIS、脑电近似熵值与丙泊酚血浆浓度的相关性。 结果：麻醉诱导5 min、术中60 min BIS值、脑电近似熵值比麻醉前均显著降低（P<0.05），且术中60 min的值显著低于麻醉诱导5 min时的值（P<0.05）；BIS值、脑电近似熵值随丙泊酚血浆浓度上升而下降，均呈显著负相关（P<0.05）；脑电近似熵在MOAA/S评分0~1分变化中有显著差异（P<0.05），而BIS值无显著差异（P>0.05）。 结论：脑电近似熵对丙泊酚药效变化评价效果与BIS相当，但其相对在麻醉镇静深度判断上有优势。
Abstract:
 Abstract: Objective To explore the application of electroencephalogram (EEG) approximate entropy in the monitoring of the depth of anesthesia. Methods Eighty patients who received elective surgery under general anesthesia from January 2017 to January 2018 were enrolled in this study. The bispectral index (BIS) and EEG approximate entropy of all patients were measured before anesthesia, at 5 min after induction, at 60 min after the beginning of surgery and at recovery from anesthesia. With different plasma concentrations of propofol and modified observer’s assessment of alertness/sedation scale (MOAA/S) scores, the changes of BIS value and EEG approximate entropy were analyzed. Finally, Pearson correlation analysis was performed to investigate the correlation of BIS and EEG approximate entropy with the plasma concentration of propofol. Results The BIS value and EEG approximate entropy at 5 min after induction and at 60 min after the beginning of surgery were significantly lower than those before anesthesia (P<0.05), and the values at 60 min after the beginning of surgery were significantly lower than those at 5 min after induction (P<0.05). The BIS value and EEG approximate entropy were negatively correlated with the plasma concentration of propofol (P<0.05). Moreover, statistical differences were found in the EEG approximate entropy when MOAA/S score was 0-1 (P<0.05), but there was no significant difference in BIS value (P>0.05). Conclusion Both EEG approximate entropy and BIS can effectively evaluate the therapeutic effects of propofol, but the former has more advantage in judging the depth of anaesthesia.

相似文献/References:

[1]王遥,霍万里,熊壮,等.TACE手术中不同站姿下铅眼镜和铅面罩对医生眼晶状体防护效果的蒙特卡洛模拟比较[J].中国医学物理学杂志,2016,33(6):553.[doi:DOI:10.3969/j.issn.1005-202X.2016.06.003]
　[J].Chinese Journal of Medical Physics,2016,33(1):553.[doi:DOI:10.3969/j.issn.1005-202X.2016.06.003]
[2]张新,谷晓芳,王培臣,等.轻离子束治疗设备注册检验关键技术问题[J].中国医学物理学杂志,2016,33(6):559.[doi:10.3969/j.issn.1005-202X.2016.06.004]
　[J].Chinese Journal of Medical Physics,2016,33(1):559.[doi:10.3969/j.issn.1005-202X.2016.06.004]
[3]江芬芬,王培,康盛伟,等. 热释光剂量片测量肺部肿瘤放疗剂量的方法[J].中国医学物理学杂志,2016,33(6):564.[doi:10.3969/j.issn.1005-202X.2016.06.005]
　[J].Chinese Journal of Medical Physics,2016,33(1):564.[doi:10.3969/j.issn.1005-202X.2016.06.005]
[4]刘洪源,彭威,杨锐,等. 锥形束CT离线校正肺癌摆位误差[J].中国医学物理学杂志,2016,33(6):573.[doi:10.3969/j.issn.1005-202X.2016.06.007]
　[J].Chinese Journal of Medical Physics,2016,33(1):573.[doi:10.3969/j.issn.1005-202X.2016.06.007]
[5]赵彪,潘香,杨毅,等. 右乳癌保乳术后瘤床同步X线和后程电子线补量调强放疗剂量学比较[J].中国医学物理学杂志,2016,33(6):576.[doi:10.3969/j.issn.1005-202X.2016.06.008]
　[J].Chinese Journal of Medical Physics,2016,33(1):576.[doi:10.3969/j.issn.1005-202X.2016.06.008]
[6]周静,吴效明.基于样本熵的睡眠呼吸暂停综合征脑电研究[J].中国医学物理学杂志,2016,33(7):722.[doi:10.3969/j.issn.1005-202X.2016.07.017]
　[J].Chinese Journal of Medical Physics,2016,33(1):722.[doi:10.3969/j.issn.1005-202X.2016.07.017]
[7]邓南,钱建庭,刁现芬,等. 基于宽带检测放疗X-光光声效应仿体实验[J].中国医学物理学杂志,2016,33(9):865.[doi:DOI:10.3969/j.issn.1005-202X.2016.09.001]
　[J].Chinese Journal of Medical Physics,2016,33(1):865.[doi:DOI:10.3969/j.issn.1005-202X.2016.09.001]
[8]张先稳,李军,张西志,等. 宫颈癌术后5野调强放疗4个变量组合的最佳治疗模式的剂量学[J].中国医学物理学杂志,2016,33(9):872.[doi:10.3969/j.issn.1005-202X.2016.09.002]
　[J].Chinese Journal of Medical Physics,2016,33(1):872.[doi:10.3969/j.issn.1005-202X.2016.09.002]
[9]胡健,李承军,徐利明,等. 床面倾斜对剂量验证通过率的影响[J].中国医学物理学杂志,2016,33(9):881.[doi:10.3969/j.issn.1005-202X.2016.09.003]
　[J].Chinese Journal of Medical Physics,2016,33(1):881.[doi:10.3969/j.issn.1005-202X.2016.09.003]
[10]陈亚正,肖明勇,孙春堂,等. 准直器角度对宫颈癌术后VMAT计划的影响[J].中国医学物理学杂志,2016,33(9):885.[doi:10.3969/j.issn.1005-202X.2016.09.004]
　[J].Chinese Journal of Medical Physics,2016,33(1):885.[doi:10.3969/j.issn.1005-202X.2016.09.004]

备注/Memo

备注/Memo:
 【收稿日期】2018-07-22
【作者简介】苏克阳，主治医师，研究方向：临床麻醉，E-mail: 1345952-
5299@139.com
【通信作者】曾景阳，硕士研究生，副主任医师，研究方向：临床麻醉，1239157939@qq.com
更新日期/Last Update: 2019-01-25