[1]张晓花,王宪福,陈雅静,等. 基于纤维束空间统计学的吸烟成瘾青少年左右脑白质不对称研究[J].中国医学物理学杂志,2019,36(1):65-70.[doi:DOI:10.3969/j.issn.1005-202X.2019.01.013]
　ZHANG Xiaohua,WANG Xianfu,CHEN Yajing,et al. TBSS-based study of left-right asymmetry of white matter in young smokers[J].Chinese Journal of Medical Physics,2019,36(1):65-70.[doi:DOI:10.3969/j.issn.1005-202X.2019.01.013]
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 基于纤维束空间统计学的吸烟成瘾青少年左右脑白质不对称研究()
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《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]

卷:
36卷
期数:
2019年第1期
页码:
65-70
栏目:
医学影像物理
出版日期:
2019-01-25

文章信息/Info

Title:
 TBSS-based study of left-right asymmetry of white matter in young smokers
文章编号:
1005-202X（2019）01-0065-06
作者:
 张晓花; 王宪福; 陈雅静; 谢东东; 刘畅; 喻大华
 内蒙古科技大学信息工程学院， 内蒙古 包头 014010
Author(s):
 ZHANG Xiaohua;  WANG Xianfu;  CHEN Yajing;  XIE Dongdong;  LIU Chang;  YU Dahua
 School of Information Engineering, Inner Mongolia University of Science and Technology, Baotou 014010, China
关键词:
 ; 吸烟成瘾; 脑白质; 左右不对称; 纤维束空间统计学
Keywords:
Keywords: smoking addiction;  white matter;  left-right asymmetry;  tract-based spatil statistics
分类号:
R318
DOI:
DOI:10.3969/j.issn.1005-202X.2019.01.013
文献标志码:
A
摘要:
 目的：观察吸烟成瘾青少年左右脑白质结构的不对称性变化。 方法：采用基于纤维束空间统计（TBSS）的分析方法，对23名青少年吸烟成瘾者的脑白质弥散张量成像（DTI）数据进行处理，观察分析出现左右脑白质结构异常不对称的脑区。 结果：通过分析，我们发现青少年成瘾者的脑白质在胼胝体部、胼胝体膝部、胼胝体压部、前放射冠、内囊前肢等脑区处的左右脑白质不对称差异值较大（FWE校正后P<0.05）。Pearson相关分析显示在胼胝体部（r=0.431, P=0.040）、胼胝体膝部（r=0.429, P=0.041）、前放射冠（r=0.477, P=0.021）这些脑区的轴向弥散率（AD）与尼古丁依赖量表（FTND）程度分数呈显著正相关，胼胝体压部与FTND呈显著负相关（r=-0.450, P=0.031）。胼胝体膝部的分数各向异性与FTND呈现显著正相关（r=0.678, P=0.000）。前放射冠的AD与吸烟指数包年（pack-year）呈现显著正相关（r=0.493, P=0.017）。 结论：青少年吸烟成瘾者的胼胝体，前放射冠等脑区的脑白质表现出了异常的左右不对称。
Abstract:
 Abstract: Objective To comprehensively analyze the left-right asymmetry of cerebral white matter structure in young smokers. Methods The diffusion tensor imaging data of cerebral white matter in 23 young smokers were processed and the brain regions with abnormal left-right asymmetries of white matter structure were analyzed with tract-based spatial statistics (TBSS) method. Results Obvious left-right asymmetries (FWE corrected P<0.05) of cerebral white matter were found in some brain regions in young smokers, including the body, genu and splenium of corpus callosum, anterior corona radiata, the anterior limb of internl capsule, etc. Pearson correlation analysis showed that the results of Fagerstrom test for nicotine dependence (FTND) were positively correlated with the axial diffusivity values of the body of corpus callosum, the genu of corpus callosum, anterior corona radiata (r=0.431, 0.429, 0.477; P=0.040, 0.041, 0.021), and negatively correlated with the axial diffusivity value of splenium of corpus callosum (r=-0.450, P=0.031). Moreover, there were significant positive correlations between the fractional anisotropy value of the genu of corpus callosum and FTND results (r=0.678, P=0.000376), and between the axial diffusivity value of anterior corona radiata and smoking index (pack-year) (r=0.493, P=0.017). Conclusion The abnormal left-right asymmetry exists in the white matter of some brain regions (such as corpus callosum and anterior corona radiate) in young smokers.

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备注/Memo

备注/Memo:
 【收稿日期】2018-08-22
【基金项目】国家自然科学基金（81571753, 81301281, 81571751）；内蒙古自治区高等学校青年科技英才支持计划（NJYT-17-B11）
【作者简介】张晓花，硕士研究生，主要研究方向：医学图像处理，E-mail: m15690321300@163.com
更新日期/Last Update: 2019-01-24