[1]梁合鹃,黄平,梁媛媛,等. 驻极体5-氟尿嘧啶贴剂药物释放规律的线性回归分析[J].中国医学物理学杂志,2018,35(12):1483-1488.[doi:DOI:10.3969/j.issn.1005-202X.2018.12.022]
　LIANG Hejuan,HUANG Ping,LIANG Yuanyuan,et al. Linear regression analysis of drug release rule in electret 5-fluorouracil patch[J].Chinese Journal of Medical Physics,2018,35(12):1483-1488.[doi:DOI:10.3969/j.issn.1005-202X.2018.12.022]
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 驻极体5-氟尿嘧啶贴剂药物释放规律的线性回归分析()
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《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]

卷:
35卷
期数:
2018年第12期
页码:
1483-1488
栏目:
医学生物物理
出版日期:
2018-12-24

文章信息/Info

Title:
 Linear regression analysis of drug release rule in electret 5-fluorouracil patch
文章编号:
1005-202X（2018）12-1483-06
作者:
 梁合鹃1; 黄平1; 梁媛媛1; 郭鑫1; 崔黎丽2; 江键1
 1.第二军医大学卫生勤务学系数理教研室， 上海 200433； 2.第二军医大学药学院无机化学教研室， 上海 200433
Author(s):
 LIANG Hejuan1;  HUANG Ping1;  LIANG Yuanyuan1;  GUO Xin1;  CUI Lili2;  JIANG Jian1
 1. Department of Physics and Mathematics, Faculty of Health Service, the Second Military Medical University, Shanghai 200433, China; 2. Department of Inorganic Chemistry, School of Pharmacy, the Second Military Medical University, Shanghai 200433, China
关键词:
 ; 驻极体; 5-氟尿嘧啶; 药物释放规律; 线性回归
Keywords:
 ; Keywords: electret;  5-fluorouracil;  drug release rule;  linear regression analysis
分类号:
R312；Q64
DOI:
DOI:10.3969/j.issn.1005-202X.2018.12.022
文献标志码:
A
摘要:
 【摘 要】 目的：采用线性回归方法研究驻极体5-氟尿嘧啶（5-Fu）贴剂的药物释放规律。 方法：利用驻极体实验技术与药剂学方法研制驻极体5-Fu贴剂，采用高效液相色谱仪检测驻极体5-Fu贴剂药物累积释放量，并对相关实验数据进行回归分析，从而将驻极体5-Fu贴剂药物释放规律模型化。 结果：（1）驻极体可以为5-Fu贴剂提供稳恒静电场，该静电场大小与驻极体等效表面电位正相关。（2）驻极体5-Fu贴剂内静电场可改变贴剂黏性，从而实现对5-Fu药物释放量的调控；电场越强，贴剂黏性越小，贴剂累积释药量（Q）越大。（3）驻极体5-Fu贴剂的释药规律满足以下回归方程：V＞0时，Q=（0.003V+13.47）t1/2+0.136 6V1/2+47.574；V=0时，Q=13.767t1/2+48.052；V＜0时，Q=（-0.003 8V+13.471）t1/2+0.162 2（-V）1/2+48.442。 结论：驻极体静电场可对5-Fu贴剂释药量进行调节，其极性和等效表面电位是调控驻极体5-Fu贴剂释药速率的关键因素。
Abstract:
 Abstract: Objective To study the drug release rule in electret 5-fluorouracil (5-Fu) patch by linear regression method. Methods The electret 5-Fu patch was prepared by electret technology and pharmaceutical method, and the cumulative drug release from 5-Fu patch were detected by high-performance liquid chromatography. Regression analysis was performed on the test data to make it possible that the drug release rule in electret 5-Fu patch be modeled. Results Electret provided stable electrostatic field for 5-Fu patch, and the size of electrostatic field had positive correlations with the equivalent surface potentials of electret. The electrostatic field of electret 5-Fu patch effectively reduced the adhesion of patch, thus realizing the regulation of 5-Fu drug release. The smaller the adhesion of patch was, the higher the cumulative drug release (Q) from patch was. The drug release rule of electret 5-Fu patch accorded with the followed regression equations: V>0, Q=(0.003V+13.47)t1/2+0.136 6V1/2+47.574; V=0, Q=13.767t1/2+48.052; V<0, Q=(-0.003 8V+13.471) t1/2+0.162 2(-V)1/2+48.442. Conclusion The electrostatic field of electret can regulate the release velocity of drug from 5-Fu patch and the polarity and equivalent surface potential of electret are the key influence factors for the regulation.

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备注/Memo

备注/Memo:
 【收稿日期】2018-07-11
【基金项目】国家自然科学基金（51477175）
【作者简介】梁合鹃，硕士，助教，研究方向：驻极体缓控释透皮给药，E-mail:1056678183@qq.com
【通信作者】江键，教授，博士生导师，研究方向：驻极体生物效应在医学中的应用和驻极体缓控释透皮给药系统，E-mail:jjiang@smmu.edu.cn
更新日期/Last Update: 2018-12-26