[1]李亮,解昕,范雪梅,等. 胸中段食管癌容积调强放疗计划的验证方法[J].中国医学物理学杂志,2019,36(1):33-36.[doi:DOI:10.3969/j.issn.1005-202X.2019.01.007]
　LI Liang,XIE Xin,FAN Xuemei,et al. Dosimetric verification of volumetric modulated arc therapy for middle thoracic esophageal carcinoma[J].Chinese Journal of Medical Physics,2019,36(1):33-36.[doi:DOI:10.3969/j.issn.1005-202X.2019.01.007]
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 胸中段食管癌容积调强放疗计划的验证方法()
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《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]

卷:
36卷
期数:
2019年第1期
页码:
33-36
栏目:
医学放射物理
出版日期:
2019-01-25

文章信息/Info

Title:
 Dosimetric verification of volumetric modulated arc therapy for middle thoracic esophageal carcinoma
文章编号:
1005-202X（2019）01-0033-04
作者:
 李亮; 解昕; 范雪梅; 徐钰梅; 章龙珍; 辛勇
 徐州医科大学附属医院肿瘤放疗科， 江苏 徐州 221002
Author(s):
 LI Liang;  XIE Xin;  FAN Xuemei;  XU Yumei;  ZHANG Longzhen;  XIN Yong
 Department of Radiation Oncology, Affiliated Hospital of Xuzhou Medical University, Xuzhou 221002, China
关键词:
 ; 胸中段食管癌; 容积调强放疗; 剂量验证; 摆位误差
Keywords:
 ; Keywords: middle thoracic esophageal carcinoma;  volumetric modulated arc therapy;  dosimetric verification;  setup error
分类号:
R811.1；R735.4
DOI:
DOI:10.3969/j.issn.1005-202X.2019.01.007
文献标志码:
A
摘要:
 目的：探讨胸中段食管癌在容积调强放疗（VMAT）中剂量与位置验证的方法。 方法：随机挑选10例胸中段食管癌病例在Varian Eclipse 10.0计划系统（TPS）中制定VMAT计划，使用IBA Compass 3.0剂量验证系统进行剂量测量，然后与TPS计划数据进行比较，分析靶区（PTV、CTV与GTV）与危及器官受照剂量和体积参数的差异，并得到其γ通过率。应用锥形束CT（CBCT）验证放疗前摆位误差，1次/周，共6周。 结果：γ分析在3 mm/3%标准下，靶区与危及器官通过率在95%以上。靶区D95%与Dmean的测量数据和TPS计算数据相差小于2%。危及器官中，双肺的V20与V30相比较于测量数据，TPS计算数据偏低，差异在1.65%以内。脊髓Dmax差异为2.23%，心脏V30、V40差异小于2%。CBCT位置验证中，前后与左右方向误差大于3 mm例数要多于头脚方向。 结论：通过Compass 3.0剂量验证系统与CBCT扫描，是保证胸中段食管癌VMAT安全和可靠的必要手段。
Abstract:
 Abstract: Objective To investigate the methods for dosimetric and location verifications in volumetric modulated arc therapy (VMAT) for middle thoracic esophageal carcinoma. Methods Varian Eclipse 10.0 treatment planning system was used to design VMAT plans for 10 patients with middle thoracic esophageal carcinoma who were randomly enrolled in this study. The doses were measured with IBA Compass 3.0 dose verification system and then compared with the data from treatment planning system (TPS). The differences in the doses and volumes of target areas (planning target volume, clinical target volume and gross tumor volume) and organs-at-risk were analyzed, and the gamma passing rates were calculated. Cone beam computed tomography (CBCT) scan was performed once a week for 6 weeks in total. Finally, the setup errors were obtained by the registration between CBCT images and positioning images. Results With the standard of 3 mm/3%, the gamma passing rates of target areas and organs-at-risk were higher than 95%. The differences between measured values of the D95% and Dmean in target areas and data from TPS were less than 2%. For the V20 and V30 of lungs, TPS data were lower than the measured values, and the difference was within 1.65%. For the Dmax of spinal cord and the V30, V40 of heart, the differences between measured values and data from TPS were 2.23% and less than 2%, respectively. Setup error analysis showed that the number of cases with error >3 mm in anterior-posterior and left-right directions was more than that of cases with error >3 mm in head-foot direction. Conclusion Compass 3.0 dose verification system and CBCT scan are necessary to ensure the safety and reliability of VMAT to treat patients with middle thoracic esophageal carcinoma.

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备注/Memo

备注/Memo:
 【收稿日期】2018-07-08
【基金项目】徐州市科技计划项目（KC15SH010）
【作者简介】李亮，硕士，主管技师，研究方向：放射物理与临床医学工程，E-mail: 46585129@qq.com
【通信作者】辛勇，博士，副教授，研究方向：放射物理与放射生物学，E-mail: deep369@163.com
更新日期/Last Update: 2019-01-24