[1]张迪,Muhammad A. Khan,秦晓,等. 基于膨胀实验数据获取角膜屈光手术后力学参数的方法初探[J].中国医学物理学杂志,2018,35(4):449-454.[doi:DOI:10.3969/j.issn.1005-202X.2018.04.015]
　ZHANG Di,Muhammad A. Khan,et al. Preliminary study on determination of mechanical parameters of cornea after refractive surgery based on inflation tests[J].Chinese Journal of Medical Physics,2018,35(4):449-454.[doi:DOI:10.3969/j.issn.1005-202X.2018.04.015]
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 基于膨胀实验数据获取角膜屈光手术后力学参数的方法初探()
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《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]

卷:
35卷
期数:
2018年第4期
页码:
449-454
栏目:
医学生物物理
出版日期:
2018-04-21

文章信息/Info

Title:
 Preliminary study on determination of mechanical parameters of cornea after refractive surgery based on inflation tests
文章编号:
1005-202X（2018）04-0449-06
作者:
 张迪1; 2; Muhammad A. Khan3; 4; 秦晓1; 2; 张海霞1; 2; 李林1; 2; 林丁3; 4; 刘志成1; 2
 1.首都医科大学生物医学工程学院， 北京 100069； 2.首都医科大学临床生物力学应用基础研究北京市重点实验室， 北京 100069； 3.中南大学爱尔眼科学院， 湖南 长沙 410015； 4.长沙爱尔眼科医院， 湖南 长沙 410015
Author(s):
 ZHANG Di1;  2;  Muhammad A. Khan3;  4;  QIN Xiao1;  2;  ZHANG Haixia1;  2;  LI Lin1;  2;  LIN Ding3;  4;  LIU Zhicheng1;  2
 1. School of Biomedical Engineering, Capital Medical University, Beijing 100069, China; 2. Beijing Key Laboratory of Fundamental Research on Biomechanics in Clinical Application, Capital Medical University, Beijing 100069, China; 3. Aier School of Ophthalmology, Central South University, Changsha 410015, China; 4. Changsha Aier Eye Hospital, Changsha 410015, China
关键词:
 ; 准分子激光原位角膜磨镶术; 角膜; 膨胀实验; 力学参数; 二阶Ogden模型; 有限元方法
Keywords:
 ; laser in situ keratomileusis;  corneal;  inflation test;  mechanical parameters;  second order Ogden model;  finite element method
分类号:
R318.01
DOI:
DOI:10.3969/j.issn.1005-202X.2018.04.015
文献标志码:
A
摘要:
 目的：基于离体膨胀实验获得的角膜顶点与压力数据，探索利用有限元方法获得屈光手术后角膜力学参数的方法。 方法：取实验兔4只，左眼为手术眼，右眼为对照眼。行标准的LASIK术实验兔2只，仅制瓣未对角膜基质层消融的实验兔2只，分别于术后不同时间点实施离体角膜膨胀实验。在离体膨胀实验中，利用位移传感器、压力传感器和显微镜分别获得角膜顶点位移、角膜内压力及角膜正侧面轮廓图像。根据获得的角膜轮廓图像构建角膜几何模型，用二阶Ogden模型描述角膜的本构关系，通过有限元方法模拟膨胀实验，将计算结果与膨胀实验数据比对确定角膜的力学参数，分析屈光手术后饲养一定时间时角膜的力学特性。 结果：角膜膨胀实验获得的角膜顶点位移与压力呈非线性关系。在相同压力下，术后饲养一定时间后的兔眼角膜顶点位移量比对照眼小。二阶Ogden模型可以较好地描述屈光手术后角膜的力学特性。屈光手术后角膜弹性模量较对照眼大。 结论：基于整体膨胀实验数据，利用有限元方法模拟角膜膨胀实验反推屈光手术后角膜力学参数的方法是可行的。
Abstract:
 Objective To explore a method for determining the mechanical parameters of cornea after refractive surgery with the use of finite element method based on the data of the corneal apex and the pressure obtained by in vitro inflation tests. Methods The left eyes of 4 New Zealand rabbits were the surgical eyes and their right eyes were the controls. Two rabbits were treated with standard laser in situ keratomileusis (LASIK), and for the other 2 rabbits, only LASIK flaps were created. The in vitro corneal inflation tests were performed at different time points after surgery. In the inflation test, corneal apex displacements, inner corneal surface pressures and corneal front profile images were obtained by displacement sensor, pressure sensor and microscope, separately. The inflation test was simulated by finite element method. In the simulated calculation, the corneal geometry model was constructed based on the obtained corneal profile images, and the second order Ogden model was used to describe the corneal constitutive relation. Finally, the corneal mechanical parameters were determined by comparing the experimental data with the calculated results. Moreover, the mechanical properties of the cornea were studied after the refractive surgery. Results Corneal apex displacements were nonlinear with the pressure. Under the same pressure, the corneal apex displacements of postoperative cornea were smaller than those of the controls. The second order Ogden model provided a good description of corneal mechanical properties after refractive surgery. The elastic moduli of the experimental eyes were larger than those of the controls. Conclusion Based on the experimental data of inflation tests, using finite element method to simulate corneal inflation tests and obtain mechanical parameters of cornea after refractive surgery is feasible.

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备注/Memo

备注/Memo:
 【收稿日期】2017-12-05
【基金项目】国家自然科学基金（31470914，31370952）；北京市属高等学校高层次人才引进与培养计划项目（CIT&TCD201504096）
【作者简介】张迪，硕士研究生，E-mail: zhangd2018@sina.com
【通信作者】张海霞，副教授，主要从事角膜生物力学研究，E-mail: zhanghx@ccmu.edu.cn
更新日期/Last Update: 2018-04-23